Potassium chloride

Potassium chloride Basic information
Chemical Properties Uses
Product Name:Potassium chloride
Synonyms:Chlorid draselny;chloriddraselny;chlorideofpotash;Chloropotassuril;Chloropotassuril diffu-K;Kaleorid;Kaleorod;Kalitabs
CAS:7447-40-7
MF:ClK
MW:74.55
EINECS:231-211-8
Product Categories:Inorganic salt, food additives;API;Crystal Grade Inorganics;Potassium Salts;PotassiumMetal and Ceramic Science;Salts;Conductivity StandardsMethod Specific;ISO 7888Alphabetic;Analytical Standards;European Community: ISO and DIN;P;Physical Properties;PON - PT;Synthetic Reagents;Biological Buffers;Buffers A to ZSerum-free Media;Companion Products and ReagentsSynthetic Reagents;O-P, Puriss p.a.;Analytical Reagents for General Use;Puriss p.a.;O-P, Puriss p.a. ACS;Puriss p.a. ACS;Pure Salts for Melting Digestions (Trace SELECT);Atomic Absorption Spectroscopy (AAS);Digestion Reagents;AlphabeticalProtein Structural Analysis;BioUltra Buffers;Optimization Reagents;X-Ray Crystallography;BiochemicalsBiological Buffers;Inorganics;Chemistry;Inorganic Salts;Insect Platform;Potassium;Buffers A to ZSynthetic Reagents;Molecular Biology;Molecular Biology Reagents;N - RSynthetic Reagents;Salt Solutions;Buffers A to ZPharmacopoeia (USP);Pharmacopoeial InorganicsBiological Buffers;Pharmacopoeia A-ZPharmacopoeia (USP);USP/MultiCompendial Grade Buffers;Buffers A to Z;Protein Structural Analysis;Optimization ReagentsSynthetic Reagents;Reference Material Silver nitrate;By Reference Material;N - RVolumetric Solutions;metal halide;19: K;Beaded Materials;Chemical Synthesis;Crystal Grade Inorganics;Inorganic Salts;K;Materials Science;Metal and Ceramic Science;Potassium Salts;Synthetic Reagents;Ultra-High Purity Materials;INORGANIC & ORGANIC CHEMICALS;Volumetric Solutions;N - R;BioUltraProtein Structural Analysis;DNA&RNA Purification;Optimization ReagentsMolecular Biology;Reagents;Cell Culture;Miscellaneous Reagents and Supplements;Reagents and Supplements;ACS Grade BuffersBiological Buffers;ACS GradeBiological Buffers;Essential Chemicals;Routine Reagents;Buffers for ISE;Analytical/Chromatography;Ion Sensor Materials;7447-40-7
Mol File:7447-40-7.mol
Potassium chloride Structure
Potassium chloride Chemical Properties
Melting point 770 °C (lit.)
Boiling point 1420°C
density 1.98 g/mL at 25 °C (lit.)
refractive index n20/D 1.334
Fp 1500°C
storage temp. 2-8°C
solubility H2O: soluble
form random crystals
Specific Gravity1.984
color White
OdorOdorless
PH5.5-8.0 (20℃, 50mg/mL in H2O)
PH Range7
Water Solubility 340 g/L (20 ºC)
λmaxλ: 260 nm Amax: 0.02
λ: 280 nm Amax: 0.01
Sensitive Hygroscopic
Merck 14,7621
Sublimation 1500 ºC
BRN 1711999
BCS Class1
Stability:Stable. Incompatible with strong oxidizing agents, strong acids. Protect from moisture. Hygroscopic.
InChIKeyWCUXLLCKKVVCTQ-UHFFFAOYSA-M
CAS DataBase Reference7447-40-7(CAS DataBase Reference)
NIST Chemistry ReferencePotassium chloride(7447-40-7)
EPA Substance Registry SystemPotassium chloride (7447-40-7)
Safety Information
Hazard Codes Xi,C,F,Xn,T
Risk Statements 36-34-11-36/37/38-40-61-60
Safety Statements 24/25-39-26-22-23-45-36/37/39-16-36/37-53
RIDADR UN 1824 8 / PGII
WGK Germany 1
RTECS TS8050000
8
TSCA Yes
HS Code 31042090
Hazardous Substances Data7447-40-7(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: 2600 mg/kg
MSDS Information
ProviderLanguage
Potassium chloride English
ACROS English
Potassium chloride Usage And Synthesis
Chemical PropertiesPotassium chloride, KCI, also known as potassium muriate and sylvite, is a colorless crystalline solid with a salty taste that melts at 776°C (1420 OF). It is soluble in water, but insoluble in alcohol. Potassium chloride is used in fertilizers, pharmaceuticals, photography, and as a salt substitute.
potassium chloride powder
potassium chloride powder

UsesPotassium chloride (KCl) is used in drug preparations and as a food additive and chemical reagent. It is possible to reduce the sodium in your diet by substituting potassium chloride for table salt (sodium chloride), which may be healthier. Molten potassium chloride is also used in the electrolytic production of metallic potassium. KCl is also found in seawater brine and can be extracted from the mineral carnallite.
DescriptionPotassium chloride (KCl) is a metal halide salt that is used in a variety of areas. The dominant application of potassium chloride is to serve as a fertilizer, which offers potassium to plants and prevents them from certain diseases. Besides, it can be applied in food and medical industry. As a treatment for hypokalemia, potassium chloride pills are taken to balance the blood's potassium levels and prevent potassium deficiency in the blood. In food industry, it serves as a electrolyte replenisher and a good salt substitute for food, as well as a firming agent to give consistent texture to food, thus to strengthen its structure.
Chemical PropertiesPotassium chloride occurs as odorless, colorless crystals or a white crystalline powder, with an unpleasant, saline taste. The crystal lattice is a face-centered cubic structure. Potassium chloride occurs naturally as the mineralsylvite (KCl) and as carnallite(KCl·MgCl2·6H2O); it is produced industriallyby fractional crystallizationof these deposits or of solutions fromlake brines. It has the interesting property of being more soluble than sodium chloride in hot water but less soluble in cold. It has low toxicity.
UsesPotassium Chloride is a nutrient, dietary supplement, and gelling agent that exists as crystals or powder. it has a solubility of 1 g in 2.8 ml of water at 25°c and 1 g in 1.8 ml of boiling water. hydrochloric acid, and sodium chloride and magnesium chloride diminish its solubility in water. it is used as a salt substitute and mineral supple- ment. it has optional use in artificially sweetened jelly and preserves. it is used as a potassium source for certain types of carrageenan gels. it is used to replace sodium chloride in low-sodium foods.
UsesPotassium chloride (KCl), commonly referred to as muriate of potash, is the most common source of potash (K2O), and accounts for about 95 % of world potash production. Virtually all (90 %) commercial potash is extracted from natural sources of potassium salt deposits occurring in thin beds in large salt basins formed by the evaporation of ancient seas. Present-day salt lakes and natural brines represent about 10 % of total recoverable potash. Extraction is followed by milling, washing, screening, flotation, crystallization, refining and drying.
More than 90 % of the total KCl consumption is used for fertilizer production. Production of potassium hydroxide accounts for more than 90 % of the non-fertilizer or industrial use of KCl. KOH is also used in the production of some agricultural-grade liquid fertilizers. uses of KCl include:
  1. Potassium chloride (KCl) is inorganic salt used for making fertilizers, since the growth of many plants is limited by their potassium intake. Potassium in plants is important for the osmotic and ionic regulation, plays a key role in the water homeostasis and is closely connected with processes involved in the protein synthesis.
  2. In photography. In buffer solutions, electrode cells.
  3. Potassium chloride may be used for the preparation of phosphate buffered saline, and for the extraction and solubilization of proteins.
  4. Used in buffer solutions, medicine, scientific applications, and food processing.
  5. Used in nutritent; gelling agent; salt substitute; yeast food.
  6. food/foodstuff additives: KCl is used as a nutrient and/or dietary supplement food additive. KCl also serves as a potassium supplement of animal feed.
  7. pharmaceutical products: KCl is an important therapeutic agent, which is used mainly in the treatment of hypokalemia and associated conditions. Hypokalemia (potassium deficiency) is a potentially fatal condition in which the body fails to retain sufficient potassium to maintain health.
  8. laboratory chemicals: KCl is used in electrode cells, buffer solutions, and spectroscopy.
  9. drilling mud for oil production industry: KCl is used as conditioner in oil drilling muds and as a shale stabilizer to prevent swelling.
  10. flame retardants and fire preventing agents: KCl is used as a component in dry chemical fire extinguisher.
  11. anti-freezing agents: KCl is used to melt ice on streets and driveways.

UsesAbout 4-5% of potash production is used in industrial applications (UNIDOIFDC, 1998). In 1996, the world supply of industrial grade potash was close to 1.35 Mt K2O. This industrial material is 98-99% pure, compared with the agricultural potash specification of 60% K2O minimum (equivalent to 95% KCl). Industrial potash should contain at least 62% K2O and have very low levels of Na, Mg, Ca, SO4 and Br. This high-grade potash is produced by only a few producers in worldwide.
Industrial grade potash analysis
Potassium hydroxide (KOH), also known as caustic potash, is the largestvolume K product for non-fertilizer use. It is produced by the electrolysis of industrial KCl and is widely used for manufacturing soaps, detergents, grease, catalysts, synthetic rubber, matches, dyes and insecticides. Caustic potash is also as a liquid fertilizer and as an ingredient in alkaline batteries and photographic film processing chemicals.
Potassium hydroxide is a raw material in the production of various K salts, mainly K carbonates, and also citrates, silicates, acetates, etc. Potassium carbonate confers excellent clarity to glass thus is used for most fine optical lenses, eyeglasses, fine crystal, glassware, chinaware and TV tubes. Potassium bicarbonate is used largely in the food and pharmaceutical industries.
Potash-derived compounds and salts are also used in the production of metal fluxes, cured meats, tempered steel, paper fumigants, case hardened steel, bleaching agents, baking powder, cream of tartar and beverages. Worldwide, industrial KCl is estimated to be used as follows: detergents and soaps, 30-35%; glass and ceramics, 25-28%; textiles and dyes 20-22%; chemicals and drugs, 13-15%; and other uses, 7-5% (UNIDO-IFDC, 1998).



Uses
  1. Potassium chloride is a widely used reagent in biochemistry and molecular biology. It is a component of phosphate buffered saline (PBS, Product No. P 3813) and of polymerase chain reaction (PCR) buffer (50 mM KCl).
  2. KCl is also used in studies of ion transport and potassium channels.
  3. KCl is also utilized in the solubilization, extraction, purification, and crystallization of proteins.
  4. The use of KCl in the crystallization of histone core octamers has been reported.
DefinitionChEBI: Potassium chloride is a metal chloride salt with a K(+) counterion. It has a role as a fertilizer. It is a potassium salt, an inorganic chloride and an inorganic potassium salt.
Production MethodsPotassium chloride occurs naturally as the mineral sylvite or sylvine; it also occurs in other minerals such as sylvinite, carnallite, and kainite. Commercially, potassium chloride is obtained by the solar evaporation of brine or by the mining of mineral deposits.
Brand nameApo-k;Celeka;Durules-k;Kadalex;Kalinorm;Kalipor;Kalium durules;K-long;Miopotasio;Plenish-k;Potasion;Roychlor;Rum-k;Swiss-kal sr;Ultra-k-chlor.
World Health Organization (WHO)Potassium chloride has been used for many years to correct potassium deficiency. The use of fast-acting tablets has been associated with lesions of the gastro-intestinal mucosa, which have led to their general withdrawal.
General DescriptionPotassium chloride (KCl) is a water-soluble metal salt that comprises of potassium and chlorine. It can be extracted from minerals and salt water. KCl can be used in industries such as cosmetics, food, biomedical, chemical and fertilizer.
Air & Water ReactionsHygroscopic. Water soluble.
Reactivity ProfilePotassium chloride is not in general strongly reactive. Violent reaction with BrF3 and with a mixture of sulfuric acid potassium permanganate mixture . Reacts with concentrated sulfuric acid to generate fumes of hydrogen chloride.
Health HazardPotassium chloride is an essential constituent of the body for intracellular osmotic pressure and buffering, cell permeability, acid-base balance, muscle contraction and nerve function.
SYMPTOMS: Large doses of Potassium chloride usually induce vomiting, so acute intoxication by mouth is rare. If no pre-existing kidney damage, it is rapidly excreted. Poisoning disturbs the rhythm of heart. Large doses by mouth can cause gastrointestinal irritation, purging, weakness, and circulatory disturbances.
Fire HazardFlammability data is not available, but Potassium chloride is probably nonflammable.
Flammability and ExplosibilityNonflammable
Agricultural UsesMuriate of potash or potassium chloride (KCl), is a major potash fertilizer. It is water soluble and is generally blended with other components to make it a multi-nutrient fertilizer. It has a higher salt index than potassium sulphate and is recommended for most crops except tobacco, potato and grapes, which are sensitive to chloride ions.
Agricultural UsesPotassium chloride (KCl), also known as muriate of potash, is generally blended with other components to make it a multinutrient fertilizer. It is a white crystalline solid, available in fine, coarse and granular grades. It is the least expensive carrier of potassium in the fertilizer market. This important fertilizer contains about 48 to 52% plant food as potassium and about 48% chloride. Coarser potassium blends well with granular N-P compounds to form an NPK-blended multinutrient fertilizer.
At least 78 % of the potassium salts are estimated to be consumed worldwide, in the form of potassium chloride, and over 90% of all processed potassium is used as fertilizer. Muck, peat and sands are generally potassiumdeficient, whereas arid soils are mostly potassium-rich, with 448 kg/ha or more of readily available potassium.
Potassium chloride is neutral and totally watersoluble. It can be applied to all soils and crops that are not sensitive to chlorides. Soluble soil-potassium is adsorbed and retained by soil colloids and thus prevented from leaching. Roots take up potassium in the ionic form.
Potassium chloride is best applied either while sowing or prior to it. However, when soils are light or coarsetextured, the applied potassium may be lost through leaching. So, it is preferable to apply potassium in split doses. On heavy soils, the fertilizer is placed advantageously in bands, as in the case of phosphatic fertilizers.
Potassium chloride is manufactured from potash minerals or brine. Sylvinite, which is a mixture of potassium chloride and halite, is the major potash mineral used for potassium chloride manufacture. A large percentage of potassium chloride is mined and refined either by the floatation or crystallization process. Both processes, of which the floatation process is more common, involve the separation of potassium chloride from sodium chloride. Fine potassium chloride is a freeflowing material which does not cake in dry places.


Pharmaceutical ApplicationsPotassium chloride is widely used in a variety of parenteral and nonparenteral pharmaceutical formulations. Its primary use, in parenteral and ophthalmic preparations, is to produce isotonic solutions.
Potassium chloride is also used therapeutically in the treatment of hypokalemia.
Many solid-dosage forms of potassium chloride exist including: tablets prepared by direct compression and granulation; effervescent tablets; coated, sustained-release tablets; sustained- release wax matrix tablets;microcapsules;pellets; and osmotic pump formulations.
Experimentally, potassium chloride is frequently used as a model drug in the development of new solid-dosage forms, particularly for sustained-release or modified-release products. Potassium chloride is also used widely in the food industry as a dietary supplement, pH control agent, stabilizer, thickener, and gelling agent. It can also be used in infant formulations.
Industrial usesPotassium chloride is a colorless or white crystallinecompound of the composition KCl, usedfor molten salt baths for the heat treatment ofsteels. The specific gravity is 1.987. A bathcomposed of three parts potassium chloride andtwo parts barium chloride is used for hardeningcarbon-steel drills and other tools. Steel toolsheated in this bath and quenched in a 3% sulfuricacid solution have a very bright surface.A common bath is made up of potassium chlorideand common salt and can be used for temperaturesup to 900°C.
Potassium chloride is used in the porcelainenamel industry as a setting-up agent in titaniumcover coats. In general, the quantities ofpotassium chloride, when used as an electrolyte,will be approximately the same as sodiumnitrite, which it replaces. However, KCl doesnot aid tearing resistance as does nitrite. Themain advantage in using potassium chloride isthe freedom from yellowing or creaming whenused in a blue-white enamel. Potassium chloridemay exert an adverse effect on the glossand may cause a slight decrease in the acidresistingproperties of the enamel, although thelatter effect is somewhat debatable.
Clinical UseHypokalaemia
Safety ProfileA human poison by ingestion. Poison experimentally by ingestion, intravenous, and intraperitoneal routes. Human systemic effects by ingestion: nausea, blood clotting changes, carhac arrhythmias. An eye irritant. Mutation data reported. Explosive reaction with BrF3; sulfuric acid + potassium permanganate. When heated to decomposition it emits toxic fumes of K2O and Cl-.
SafetyPotassium chloride is used in a large number of pharmaceutical formulations, including oral, parenteral, and topical preparations, both as an excipient and as a therapeutic agent.
Potassium ions play an important role in cellular metabolism and imbalances can result in serious clinical effects. Orally ingested potassium chloride is rapidly absorbed from the gastrointestinal tract and excreted by the kidneys. Potassium chloride is more irritant than sodium chloride when adminstered orally, and ingestion of large quantities of potassium chloride can cause effects such as gastrointestinal irritation, nausea, vomiting, and diarrhea.
High localized concentrations of potassium chloride in the gastrointestinal tract can cause ulceration: hence the development of the many enteric-coated and wax matrix sustained-release preparations that are available.Although it is claimed that some formulations cause less ulceration than others, it is often preferred to administer potassium chloride as an aqueous solution. However, solutions have also been associated with problems, mainly due to their unpleasant taste.
Parenterally, rapid injection of strong potassium chloride solutions can cause cardiac arrest; in the adult, solutions should be infused at a rate not greater than 750 mg/hour.
Therapeutically, in adults, up to 10 g orally, in divided doses has been administered daily, while intravenously up to 6 g daily has been used.
(guinea pig, oral): 2.5 g/kg
(mouse, IP): 1.18 g/kg
(mouse, IV): 0.12 g/kg
(mouse, oral): 0.38 g/kg
(rat, IP): 0.66 g/kg
(rat, IV): 0.14 g/kg
(rat, oral): 2.6 g/kg
Drug interactionsPotentially hazardous interactions with other drugs
ACE inhibitors and angiotensin-II antagonists: increased risk of hyperkalaemia.
Ciclosporin: increased risk of hyperkalaemia.
Potassium-sparing diuretics: increased risk of hyperkalaemia.
Tacrolimus: increased risk of hyperkalaemia.
MetabolismPotassium is excreted mainly by the kidneys; it is secreted in the distal tubules in exchange for sodium or hydrogen ions. Some potassium is excreted in the faeces and small amounts may also be excreted in sweat.
storagePotassium chloride tablets become increasingly hard on storage at low humidities. However, tablets stored at 76% relative humidity showed no increase or only a slight increase in hardness.The addition of lubricants, such as 2% w/w magnesium stearate, reduces tablet hardness and hardness on aging.Aqueous potassium chloride solutions may be sterilized by autoclaving or by filtration.
Potassium chloride is stable and should be stored in a well-closed container in a cool, dry place.
Purification MethodsDissolve it in conductivity water, filter it, and saturate it with chlorine (generated from conc HCl and KMnO4). Excess chlorine is boiled off, and the KCl is precipitated by HCl (generated by dropping conc HCl into conc H2SO4). The precipitate is washed with water, dissolved in conductivity water at 90-95o, and crystallised by cooling to about -5o. The crystals are drained at the centrifuge, dried in a vacuum desiccator at room temperature, then fused in a platinum dish under N2, cooled and stored in a desiccator. Potassium chloride has also been sublimed in a stream of pre-purified N2 gas and collected by electrostatic discharge [Craig & McIntosh Can J Chem 30 448 1952].
IncompatibilitiesPotassium chloride reacts violently with bromine trifluoride and with a mixture of sulfuric acid and potassium permanganate. The presence of hydrochloric acid, sodium chloride, and magnesium chloride decreases the solubility of potassium chloride in water. Aqueous solutions of potassium chloride form precipitates with lead and silver salts.
Intravenous aqueous potassium chloride solutions are incompatible with protein hydrolysate.
Regulatory StatusGRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections, ophthalmic preparations, oral capsules, and tablets). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Referenceshttps://en.wikipedia.org/wiki/Potassium_chloride
https://www.drugbank.ca/drugs/DB00761
http://study.com/academy/lesson/what-is-potassium-chloride-uses-formula-side-effects.html
POTASSIUM ACRYLATE Losartan potassium GLUCOSAMINE SULFATE POTASSIUM CHLORIDE Potassium sorbate Lithium chloride-potassium chloride Potassium bromate Tosylmethyl isocyanide Potassium persulfate MAGNESIUM POTASSIUM CHLORIDE Potassium Acetate Potassium chloride Glucosamine sulfate Potassium POTASSIUM CYANIDE 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile PCR BUFFER Potassium nitrate Potassium sulfate Muriate Of Potash

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.