| Originator | Renagel,Chugai Pharmaceutical |
| Uses | Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure or patients suffering from chronic kidney disease. |
| Uses | Sevelamer hydrochloride is a noncalcemic phosphate binder for the treatment of hyperphosphatemia in chronic renal failure. |
| Uses | Sevelamer HCl is used in the treatment of hyperphosphataemia in patients suffering from chronic kidney disease. |
| Definition | ChEBI: Sevelamer hydrochloride is an epoxide. |
| Manufacturing Process | Poly(allylamine hydrochloride) (50% w/w, 426 kg) was charged to a 1000 L reactor and water (200 L) was added. Sodium hydroxide solution (32% w/w,
208 kg) was added, followed by 85 L of water. The mixture was stirred for 1 h
and filtered to a 2500 L reactor. The transfer line was rinsed with water (217
kg) and acetonitrile (1300 L) added. The temperature was adjusted to 40°C
and epichlorohydrin (20 kg) added. The mixture was stirred at 40° to 50°C for
1.5 h and then heated to reflux for 16 h. The resulting product slurry may be
isolated and washed in decanter centrifuge.
|
| Brand name | Renagel (Genzyme). |
| Therapeutic Function | Antihyperphosphatemic |
| Veterinary Drugs and Treatments | Sevalamer may be useful for treating hyperphosphatemia associated
with chronic renal failure, particularly when oral aluminum
salts are not tolerated. |
