Indoramin

Indoramin Basic information

Product Name:	Indoramin
Synonyms:	Indoramine;N-[1-[2-(1H-Indol-3-yl)ethyl]piperidin-4-yl]benzamide;Wy-21901;Benzamide, N-[1-[2-(1H-indol-3-yl)ethyl]-4-piperidinyl]-;Indoramin USP/EP/BP
CAS:	26844-12-2
MF:	C22H25N3O
MW:	347.45
EINECS:	248-041-5
Product Categories:
Mol File:	26844-12-2.mol

Indoramin Chemical Properties

Melting point	208-210°
Boiling point	600.0±45.0 °C(Predicted)
density	1.21±0.1 g/cm3(Predicted)
pka	14.32±0.20(Predicted)

Safety Information

MSDS Information

Indoramin Usage And Synthesis

Originator	Baratol,Wyeth,UK,1981
Uses	Antihypertensive.
Definition	ChEBI: Indoramin is a member of tryptamines.
Manufacturing Process	4-Benzamido-1-[2-(3-indolyl)ethyl] pyridinium bromide (3.0 g) was dissolved in 91% ethanol (300 ml) containing triethylamine (0.08 g) and freshly prepared W7 Raney nickel catalyst (ca 3 g) was added. The mixture was hydrogenated in an autoclave at 400 psi hydrogen pressure and 50°C for 4 hours. After filtering off the catalyst the filtrate was evaporated in vacuo and the residue was shaken with a mixture of chloroform and 2N sodium hydroxide solution. The resulting insoluble material was filtered off and dried to give 1.61 g of product, MP 203°C to 206°C. Recrystallization from ethanol gave the title compound as colorless needles (1.34 g), MP 208°C to 210°C.
Therapeutic Function	Antihypertensive

Indoramin Preparation Products And Raw materials

Raw materials

Hydrogen-->Inosine

Indapamide sustained release tablets Indapamide methyl(2,3,3-trimethyltrinorbornan-2-yl)amine Acebutolol Bisoprolol N-(1-(2-(1H-Indol-3-yl)ethyl)-4-piperidinyl)-(1,1'-biphenyl)-4-carboxamide N-PIPERIDIN-4-YL-BENZAMIDE INDORAMIN HYDROCHLORIDE Indoramin

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