ChemicalBook Product Catalog Biochemical Engineering Polypeptide H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH

H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH

H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH Basic information
Product Name:H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH
Synonyms:H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH;BETA-AMYLOID (12-28);BETA-AMYLOID PEPTIDE [12-28], HUMAN;ALZHEIMER'S DISEASE BETA-PROTEIN (12-28);AMYLOID, BETA- (12-28), HUMAN;AMYLOID BETA-PROTEIN (12-28);AMYLOID-BETA PROTEIN (12-28), HUMAN;AMYLOID BETA-PROTEIN FRAGMENT 12-28
CAS:107015-83-8
MF:C89H135N25O25
MW:1955.18
EINECS:
Product Categories:peptide;Amyloid beta Protein Fragments;Neurodegenerative Disease Peptides;Neuropeptides;Amyloid beta-peptide and related;Alzheimer
Mol File:107015-83-8.mol
H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH Structure
H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH Chemical Properties
storage temp. −20°C
solubility ≥195.5 mg/mL in DMSO; insoluble in EtOH; ≥59.8 mg/mL in H2O
form solid
Water Solubility Soluble to 0.70 mg/ml in water
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH Usage And Synthesis
Biological Activityamyloid beta (aβ or abeta) is a peptide of 36–43 amino acids that is processed from the amyloid precursor protein. while best known as a component of amyloid plaques in association with alzheimer's disease, evidence has been found that aβ is a highly multifunctional peptide with significant non-pathological activity(1). aβ is the main component of deposits found in the brains of patients with alzheimer's disease. brain aβ is elevated in patients with sporadic alzheimer’s disease. aβ is the main constituent of brain parenchymal and vascular amyloid, it contributes to cerebrovascular lesions and is neurotoxic(2).figure1 formula of amyloid β-peptide (12-28) (human)figure2 signal pathway of amyloid β
references1. Lahiri DK, Maloney B (September 2010). "Beyond the signaling effect role of amyloid–β42 on the processing of AβPP, and its clinical implications". Exp. Neurol. 225 (1): 51–4.2. Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M (September 1998). "Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau". Nat. Neurosci. 1 (5): 355–8.
H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH Preparation Products And Raw materials
β-Amyloid (18-28) β-Amyloid (13-27) H-GLU-ASP-VAL-GLY-SER-ASN-LYS-GLY-ALA-ILE-ILE-GLY-LEU-MET-OH AMYLOID BETA-PROTEIN (40-1) H-HIS-HIS-GLY-VAL-VAL-GLU-VAL-ASP-ALA-ALA-VAL-THR-PRO-GLU-GLU-ARG-HIS-LEU-SER-LYS-OH β- Amyloid (1-34) β- Amyloid (4-10) AMYLOID BETA-PROTEIN (1-38) H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-OH β-Amyloid (10-35), amide β-Amyloid (12-20) H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH H-CYS-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH FAM-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH TAMRA-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH H-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH BIOTIN-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-LYS-LEU-VAL-PHE-PHE-ALA-GLU-ASP-VAL-GLY-SER-ASN-LYS-OH (GLN11)-AMYLOID BETA-PROTEIN (1-28)
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