N-NITROSODIETHANOLAMINE

N-NITROSODIETHANOLAMINE Basic information
Product Name:N-NITROSODIETHANOLAMINE
Synonyms:2,2’-nitrosiminodi-ethano;bis-(2-hydroxy-ethyl)-nitroso-amine;bis(beta-hydroxyaethyl)nitrosamin;bis(beta-hydroxyethyl)nitrosamine;bis-2-hydroxy-ethyl-nitroso-amine;di-(2-hydroxyethyl)-nitrosamine;diaethanolnitrosamin;diethanolnitrosoamine
CAS:1116-54-7
MF:C4H10N2O3
MW:134.13
EINECS:214-237-4
Product Categories:Amines;Nitric Oxide Reagents;Nitrosamine;pharmacetical
Mol File:1116-54-7.mol
N-NITROSODIETHANOLAMINE Structure
N-NITROSODIETHANOLAMINE Chemical Properties
Melting point 200 °C (decomp)
Boiling point bp0.01 125°
density 1,26 g/cm3
refractive index nD20 1.4849
Fp 11℃
storage temp. 2-8°C
Water Solubility Completely miscible in water
solubility DMSO (Soluble), Ethyl Acetate (Sparingly), Methanol (Soluble), Water (Sparingly)
pka13.76±0.10(Predicted)
form clear liquid to slightly cloudy liquid
color Light yellow to Brown
Merck 14,6634
BRN 1762620
CAS DataBase Reference1116-54-7(CAS DataBase Reference)
IARC2B (Vol. 17, Sup 7, 77) 2000
EPA Substance Registry SystemN-Nitrosodiethanolamine (1116-54-7)
Safety Information
Hazard Codes T,F
Risk Statements 45-11
Safety Statements 53-45-16
RIDADR UN 1993 3/PG 2
WGK Germany 1
RTECS KL9550000
HS Code 2922.19.9690
HazardClass 3.1
PackingGroup II
Hazardous Substances Data1116-54-7(Hazardous Substances Data)
ToxicityLD50 orl-rat: 7500 mg/kg GISAAA 40(1),81,75
MSDS Information
ProviderLanguage
SigmaAldrich English
N-NITROSODIETHANOLAMINE Usage And Synthesis
Chemical PropertiesReddish Yellow Oil
UsesA potent liver carcinogen in several species of animals, is one of the most widespread N-nitroso compounds in the human environment.
DefinitionChEBI: N-Nitrosodiethanolamine is a nitroso compound.
General DescriptionYellow to dark brown very viscous liquid with no distinct odor.
Air & Water ReactionsWater soluble.
Reactivity ProfileN-NITROSODIETHANOLAMINE can react with alkoxides. N-NITROSODIETHANOLAMINE reacts with sulfuric acid at temperatures above 311° F.
Health HazardACUTE/CHRONIC HAZARDS: N-NITROSODIETHANOLAMINE may be harmful by eye or skin contact, inhalation or ingestion. It is an irritant and, when heated to decomposition, it emits toxic fumes of carbon monoxide, carbon dioxide and nitrogen oxides.
Fire HazardFlash point data for N-NITROSODIETHANOLAMINE are not available; however, N-NITROSODIETHANOLAMINE is probably combustible.
Safety ProfileConfirmed carcinogen with experimental carcinogenic, neoplastigenic, and tumorigenic data.Mildly toxic by ingestion. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx. See also N-NITROSO COMPOUNDS and ALCOHOLS.
CarcinogenicityN-Nitrosodiethanolamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals.
Purification MethodsPurify NDELA by dissolving the amine (0.5g) in 1-propanol (10mL) and 5g of anhydrous Na2SO4 added with stirring. After standing for 1-2hours, it is filtered and passed through a chromatographic column packed with 10mL of AG 50W x 8 (H+form 50-100mesh, a strongly acidic cation exchanger). The eluent and washings (50 mL EtOH) are combined and evaporated to dryness at 35o. It has also been extracted with EtOH from the nitrosation mixture of ethanolamine, filtered and distilled under high vacuum. [Fukuda et al. Anal Chem 53 2000 1981, Jones & Wilson J Chem Soc 550, 1949, Beilstein 1 III 721, see Spiegelhalder et al. N-Nitroso Compounds: Occurrence Biological Effects and Relevance in Human Cancer (eds. O’Neill et al. IARC Scientific Publications No 57; IARC Lyon p943 1984.] Possible
N-NITROSODIETHANOLAMINE SOLUTION 100UG/ML IN METHANOL 5ML N-nitroso-2-methoxy-2,6-dimethylmorpholine N-nitrosobis(2-acetoxypropyl)amine N-Nitrosodiethanolamine-d8 Hydrochloride N-NITROSODIETHANOLAMINE SOLUTION 100UG/ML IN METHANOL 1ML N-nitrosoiminodiacetic acid DIISOPROPANOLNITROSAMINE 4-NITROSO-MORPHOLINE-3-CARBOXYLIC ACID NITROSOBIS(2-HYDROXYETHYL)-D8-AMINE N-NITROSODIETHANOLAMINE SOLUTION 100UG/ML IN METHANOL 5X1ML N-nitroso-2-hydroxymorpholine N-NITROSOBIS(ACETOXYETHYL)AMINE N-NITROSODIETHANOLAMINE N-NITROSODIETHYLAMINE

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