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LCZ696 InteMediate

LCZ696 InteMediate Basic information
Product Name:LCZ696 InteMediate
Synonyms:N-[(1R)-2-[1,1'-Biphenyl]-4-yl-1-(hydroxymethyl)ethyl]carbamic acid 1,1-dimethylethyl ester;LCZ696 InteMediate;(R)-tert-butyl (1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbaMate;LCZ696(valsartan + sacubitril) impurity 29;(R) -tert-butyl (1-([1,1'-biphenyl] -4-yl) -3-hydroxypropane-2-yl) carbamate;(R)-tert-butyl (1-([1;1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate;tert-butyl (R)-(1-([1,1'-biphenyl]-4-yl)-3-hydroxypropan-2-yl)carbamate
CAS:1426129-50-1
MF:C20H25NO3
MW:327.42
EINECS:202-804-9
Product Categories:LCZ696;LCZ 696;1426129-50-1
Mol File:1426129-50-1.mol
LCZ696 InteMediate Structure
LCZ696 InteMediate Chemical Properties
Boiling point 514.5±50.0 °C(Predicted)
density 1.103±0.06 g/cm3(Predicted)
storage temp. 2-8°C
pka11.85±0.46(Predicted)
InChIInChI=1S/C20H25NO3/c1-20(2,3)24-19(23)21-18(14-22)13-15-9-11-17(12-10-15)16-7-5-4-6-8-16/h4-12,18,22H,13-14H2,1-3H3,(H,21,23)/t18-/m1/s1
InChIKeyTYQICOFAZDVKMK-GOSISDBHSA-N
SMILESC(OC(C)(C)C)(=O)N[C@@H](CO)CC1=CC=C(C2=CC=CC=C2)C=C1
Safety Information
MSDS Information
LCZ696 InteMediate Usage And Synthesis
UsesN-?[(1R)?-?2-?[1,?1''-?Biphenyl]?-?4-?yl-?1-?(hydroxymethyl)?ethyl]?-carbamic Acid 1,?1-?Dimethylethyl Ester is a useful intermediate for preparing Sacubitril (S080900)/Valsartan (V095750).
LCZ696 InteMediate Preparation Products And Raw materials
Raw materialsMETHYL-N-TERT-BUTYLOXYCARBONYL-AMINO-4,4'-BIPHENYL-R-ALANINE-->BOC-D-4,4'-BIPHENYLALANINE
(S)-5-[(Biphenyl-4-yl)carbonyl]pyrrolidin-2-one (R,E)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoate (2S,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid (2R,4S)-4-([1,1'-Biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoic acid (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoate LCZ Impurity Sacubitril Impurity 72 Valsartan AHU-377 2-Pyrrolidinone, 5-([1,1'-biphenyl]-4-ylMethyl)-3-Methyl-, (3R,5S)- (2R,4S)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpentanoic acid AHU-377 (heMicalciuM salt) LCZ696 ((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester (S)-5-[(Biphenyl-4-yl)methyl]-1-(2,2-dimethylpropionyl)pyrrolidin-2-one (2R,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid (2R,4S)-ethyl 5-([1,1'-biphenyl]-4-yl)-4-aMino-2-Methylpentanoate LCZ696 interMediate
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