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| | Isonicotinamide Basic information |
| | Isonicotinamide Chemical Properties |
| Melting point | 155-157 °C(lit.) | | Boiling point | 227.52°C (rough estimate) | | density | 1.2236 (rough estimate) | | refractive index | 1.5350 (estimate) | | storage temp. | Store below +30°C. | | solubility | DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | pK1: 3.61(+1) (20°C) | | color | White to Off-White | | Water Solubility | 191.7 g/L (37 ºC) | | BRN | 2173 | | LogP | -0.28 | | CAS DataBase Reference | 1453-82-3(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Pyridinecarboxamide(1453-82-3) | | EPA Substance Registry System | Isonicotinamide (1453-82-3) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | RTECS | NR9500000 | | Hazard Note | Irritant | | TSCA | Yes | | HS Code | 29333999 |
| | Isonicotinamide Usage And Synthesis |
| Chemical Properties | white crystalline powder | | Uses | Isonicotinamide is an isomeric analogue of nicotinamide and a metabolite of isonicotinic thioamide. Isonicotinamide strongly inducde apoptosis in human acute myelomonocytic leukemia cells, HL-60. | | Application | Isonicotinamide (pyridine-4-carboxamide) can be used as a heterocyclic building block to synthesize:
4-oxo-1,3-thiazinan-3-yl isonicotinamide derivatives as potential anti-tubercular agents.
Organotin(IV) complexes of isonicotinamide via synthesis of phosphoramidate ligands for various biological activity studies.
Bis-pyridinium isonicotinamide derivatives of 2-(hydroxyimino)-N-(pyridin-3-yl)acetamide as potent reactivators sarin.
Isonicotinamide can also be used as a co-former with active pharmaceutical ingredients (APIs) to prepare co-crystals. | | Preparation | synthesis of isonicotinamide: In 6g tert-amyl alcohol, add 100mg ferric oxide, 100mg cobalt tetroxide and 100mg manganese dioxide (mass percentage in the mixture: 4.6%), 60mg 4-cyanopyridine (mass percentage in the mixture: 0.91%), 200uL Water (mass percentage in the mixture: 3.0%), mix well; react at 80°C for 24 hours, the conversion rate of 4-cyanopyridine is 99.0%, and the selectivity of the corresponding Isonicotinamide is 99.0%. | | Definition | ChEBI: Isonicotinamide is a pyridinecarboxamide that is the monocarboxylic acid amide derivative of isonicotinic acid. It derives from an isonicotinic acid. | | Purification Methods | Recrystallise isonicotinamide from hot water or isopropanol (158.5-159o), and dry it in a vacuum at 100o. The picrate crystallises from aqueous EtOH or H2O and has m 217-218o (214-215o). [Beilstein 22 III/IV 527, 22/2 V 195.] |
| | Isonicotinamide Preparation Products And Raw materials |
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