Medroxyprogesterone Acetate

Medroxyprogesterone Acetate Basic information
Product Name:Medroxyprogesterone Acetate
Synonyms:MEDROXYPROGESTERONE ACETATE, FOR PERFORMANCE TEST EP STANDARD;Medroxyprogesterone Acetate, Micronized;17α-Acetoxy-6α-methylprogesterone, 6α-Methyl-17α-acetoxyprogesterone, 6α-Methyl-17α-hydroxyprogesterone acetate, Depo-provera, 17α-Hydroxy-6α-methyl-4-pregnene-3,20-dione 17-acetate;(6-alpha)-Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl;Pregn-4-ene-3,20-dione, 17-(acetyloxy)-6-methyl-, (6.alpha.)-;17α-acetoxy-6α-methylprogesterone;6a-methyl-17a-acetoxyprogesterone;MEDROXYPROGESTERONEACETATE,MICRONIZED,USP
CAS:71-58-9
MF:C24H34O4
MW:386.52
EINECS:200-757-9
Product Categories:Antitumors for Research and Experimental Use;Biochemistry;Hydroxyketosteroids;Steroids;PROVERA;API;Hormone Drugs;Intermediates & Fine Chemicals;Pharmaceuticals;Steroid and Hormone;71-58-9
Mol File:71-58-9.mol
Medroxyprogesterone Acetate Structure
Medroxyprogesterone Acetate Chemical Properties
Melting point 206-207 °C(lit.)
alpha D +61° (in chloroform)
Boiling point 432.7°C (rough estimate)
density 1.0346 (rough estimate)
refractive index 48 ° (C=1, Dioxane)
storage temp. Sealed in dry,2-8°C
solubility Practically insoluble in water, freely soluble in methylene chloride, soluble in acetone, sparingly soluble in ethanol (96 per cent)
form neat
color White
Water Solubility <0.1 g/100 mL at 23 ºC
Merck 13,5817
BRN 2066112
BCS Class2,3,1
Stability:Stable, but weakly air and light sensitive. Incompatible with strong oxidizing agents.
CAS DataBase Reference71-58-9(CAS DataBase Reference)
IARC2B (Vol. 21, Sup 7) 1987
EPA Substance Registry SystemMedroxyprogesterone acetate (71-58-9)
Safety Information
Hazard Codes Xn
Risk Statements 40-48
Safety Statements 22-36/37/39-45
WGK Germany 3
RTECS TU5010000
HS Code 29372390
MSDS Information
Medroxyprogesterone Acetate Usage And Synthesis
DescriptionMedroxyprogesterone Acetate, also known as Medroxyprogesterone 17-acetate or MPA, is a synthetic progestogen and a steroidal progestin. It is derived from the human hormone progesterone. It prevents fertilization and increases the rate of transport of eggs from the fallopian tubes to the uterus in female ferrets when administered prior to ovulation. Medroxyprogesterone 17-acetate reversibly blocks ovulation in rats when injected on the last day of diestrus. It also has anti-androgenic activity in rats, decreasing plasma testosterone levels via induction of hepatic testosterone reductase activity. Medroxyprogesterone 17-acetate exhibits immunosuppressive effects in vitro and in vivo, inhibiting the production of IFN-γ by CD2/CD3/CD28-stimulated peripheral blood mononuclear cells (PBMCs) at concentrations ≥10 nM and extending the survival of rabbit skin allografts. Injectable formulations containing medroxyprogesterone 17-acetate have been used as contraceptives.
Chemical PropertiesWhite or almost white, crystalline powder.
OriginatorProvera,Upjohn,US,1959
UsesMedroxyprogesterone Acetate is a synthetic progesterone receptor agonist that is used to treat amenorrhea (unusual stopping of menstrual periods) and abnormal uterine bleeding.
DefinitionChEBI: Medroxyprogesterone acetate is an acetate ester resulting from the formal condensation of the 17alpha-hydroxy group of medroxyprogesterone with the carboxy group of acetic acid. A widely used progestin in menopausal hormone therapy and in progestogen-only birth control. It has a role as a progestin, an androgen, a female contraceptive drug, a synthetic oral contraceptive, an adjuvant, an inhibitor, an antioxidant and an antineoplastic agent. It is a steroid ester, an acetate ester, a 20-oxo steroid, a 3-oxo-Delta(4) steroid and a corticosteroid. It is functionally related to a medroxyprogesterone.
Brand nameAmen (Amarin); Curretab (Solvay Pharmaceuticals); Cycrin (ESI); Provera (Pharmacia & Upjohn);Clinovie;Cliovir;Dep0-clinover;Dep0-map;Depcorlutin;Depo-prodasone;Depo-progevera;Depo-promone;Deporone;Dugen;Farlurin;Farlutale;Gesinal;Gestapuran;Gestapuron;G-farlutal;Hysron;Intex;Luteocrin orale;Luteodione;Luteos;Lutoporal;Metigestene;Nadigest;Nogest;Onco-provera;Perlutest;Petogen;Piermap;Povera;Promone-e;Pronone;Proverone;Provest;Sindomens;Sodelut "g";Supprestal;Verafen;Veramix plus v.
Therapeutic FunctionProgestin
World Health Organization (WHO)A depot preparation containing 150 mg medroxyprogesterone acetate was introduced over 20 years ago for use as a long-acting injectable contraceptive. Subsequently, positive results of carcinogenicity studies carried out in beagle bitches led to refusal of registration in the United States. These findings were later considered irrelevant to contraceptive use in women and the drug was approved by the Food and Drug Administration. Menstrual irregularities are the most common adverse effect associated with depot medroxyprogesterone acetate. Risk-benefit judgements differ significantly from country to country, having regard to differing national circumstances. The preparation is, however, widely available and is included in the WHO Model List of Essential Drugs. (Reference: (WHTAC4) The Use of Essential Drugs, 4th Report of the WHO Expert Committee, 796, , 1990)
General DescriptionMedroxyprogesterone acetate is an odorless white to off-white microcrystalline powder. It is a synthetic, acetate derivative of the sex hormone progesterone. (NTP, 1992)
Air & Water ReactionsMedroxyprogesterone 17-acetate is sensitive to prolonged exposure to air and light. Insoluble in water.
Reactivity ProfileFlammable and/or toxic gases are generated by the combination of alcohols with alkali metals, nitrides, and strong reducing agents. They react with oxoacids and carboxylic acids to form esters plus water. Oxidizing agents convert them to aldehydes or ketones. Alcohols exhibit both weak acid and weak base behavior. They may initiate the polymerization of isocyanates and epoxides.
HazardPossible carcinogen.
Fire HazardFlash point data for Medroxyprogesterone 17-acetate are not available; however, Medroxyprogesterone 17-acetate is probably combustible.
Biochem/physiol ActionsMedroxyprogesterone 17-acetate (MPA) is a synthetic progestin used as a contraceptive, in hormone replacement therapy and for the treatment of endometriosis. It is a more potent progestin that the nonacetylated form.
Clinical UseProgestogen:
Cachexia (unlicensed), contraception, epilepsy, male hypersexuality, malignant neoplasms, respiratory disorders, sickle-cell disease, dysfunctional uterine bleeding, endometriosis
Safety ProfileSuspected carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Human systemic effects by intravenous route: increased intraocular pressure. Human teratogenic effects by an unspecified route: developmental abnormalities of the urogenital system. Human reproductive effects by multiple routes: spermatogenesis, menstrual cycle changes or dlsorders, postpartum effects, female fertility effects, abortion, newborn behavioral effects. Human mutation data reported. Experimental reproductive effects. A drug for the treatment of secondary amenorrhoea and dysfunctional uterine bleeding. When heated to decomposition it emits acrid smoke and irritating fumes.
Veterinary Drugs and TreatmentsIn cats, MPA has been used when either castration is ineffective or undesirable to treat sexually dimorphic behavior problems such as roaming, inter-male aggressive behaviors, spraying, mounting, etc. MPA has also been used as a tranquilizing agent to treat syndromes such as feline psychogenic dermatitis and alopecia, but treatment with “true” tranquilizing agents may be preferable.
In humans, parenteral MPA has been used as a long-acting contraceptive in females, to decrease sexually deviant behavior in males, and as an antineoplastic agent for some carcinomas (see Pharmacology section above). Oral MPA is used in human females to treat secondary amenorrhea and to treat abnormal uterine bleeding secondary to hormone imbalances.
MetabolismAmong the first of these substituted 17α-acetoxyprogesterone analogues to be utilized therapeutically was medroxyprogesterone acetate, a 6α-methyl progesterone analogue. This analogue is 25-fold more active than ethisterone. Following oral administration, medroxyprogesterone acetate is completely and rapidly deacetylated by first-pass metabolism to medroxyprogesterone. Medroxyprogesterone is extensively metabolized via pathways similar to those for progesterone, except for 6α-hydroxylation. Most medroxyprogesterone acetate metabolites are excreted in the urine, primarily as glucuronide conjugates. Plasma protein binding for medroxyprogesterone is approximately 86%, primarily to serum albumin, with no binding to SHBG.
References1. Chang, M.C. Effects of medroxyprogesterone acetate and of ethinyl oestradiol on the fertilization and transportation of ferret eggs. J. Reprod. Fertil. 13(1), 173-174 (1967). DOI:10.1530/JRF.0.0130173
2. Dickmann, Z. Short-and long-term effects of a single injection of depo-medroxyprogesterone acetate (provera) on the vaginal smear, ovulation and mating in the rat. J. Reprod. Fertil. 32(3), 447-451 (1973). DOI:10.1530/JRF.0.0320447
3. Albin, J., Vittek, J., Gordon, G.G., et al. On the mechanism of the anti-androgenic effect of medroxyprogesterone acetate. Endocrinology 93(2), (1973). DOI:10.1210/ENDO-93-2-417
4. Huijbregts, R.P., Michel, K.G., and Hel, Z. Effect of progestins on immunity: Medroxyprogesterone but not norethisterone or levonorgestrel suppresses the function of T cells and pDCs. Contraception 90(2), 123-129 (2014). DOI:10.1016/j.contraception.2014.02.006
5. Turcotte, J.G., Haines, R.F., Brody, G.L., et al. Immunosuppression with medroxyprogesterone acetate. Transplantation 6(2), 248-260 (1968). DOI:10.1097/00007890-196803000-00010
6. Hofmeyr, G.J., Singata-Madliki, M., Lawrie, T.A., et al. Effects of the copper intrauterine device versus injectable progestin contraception on pregnancy rates and method discontinuation among women attending termination of pregnancy services in South Africa: A pragmatic randomized controlled trial. Reprod. Health 13, 42 (2016). DOI:10.1186/s12978-016-0153-9
7. Thomas CP, Liu KZ, Vats HS. Medroxyprogesterone acetate binds the glucocorticoid receptor to stimulate alpha-ENaC and sgk1 expression in renal collecting duct epithelia. Am J Physiol Renal Physiol. 2006 Feb;290(2):F306-12. Epub 2005 Sep 27. DOI:10.1152/AJPRENAL.00062.2005
8. Braden BB, Talboom JS, Crain ID, Simard AR, Lukas RJ, Prokai L, Scheldrup MR, Bowman BL, Bimonte-Nelson HA. Medroxyprogesterone acetate impairs memory and alters the GABAergic system in aged surgically menopausal rats. Neurobiol Learn Mem. 2010Mar;93(3):444-53. DOI:10.1016/j.nlm.2010.01.002
Medroxyprogesterone Acetate Preparation Products And Raw materials
Raw materialsSulfuric acid-->Ethylene glycol-->Peroxyacetic acid-->Methylmagnesium Bromide-->Acetic anhydride
Preparation ProductsMEDROXYPROGESTERONE-->17-(Acetyloxy)-6α-methyl-5β-pregnane-3,20-dione
17-Hydroxy-6-methylpregn-4-ene-3,20-dione 17-acetate Megestrol acetate EP Impurity E (2β)-Methyl Megestrol Acetate 4,7-Dihydro Megestrol Acetate AQMUMBCTNJGBGC-FGPIKTEISA-N Megestrol Hydroxyprogesterone acetate Megestrol acetate 17-hydroxy-6-methylenepregn-4-ene-3,20-dione 17-acetate Premarin Goserelin acetate Clometerone Algestone acetophenide Acetoxy Gestonorone ACETATE D-1-MEDROXYPROGESTERONE-17-ACETATE CHLOROPHOSPHONAZO III

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