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| | ECHINACOSIDE Basic information |
| | ECHINACOSIDE Chemical Properties |
| Boiling point | 1062.7±65.0 °C(Predicted) | | density | 1.66±0.1 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | DMSO:60.0(Max Conc. mg/mL);76.26(Max Conc. mM)
DMSO:PBS (pH 7.2) (1:9):0.1(Max Conc. mg/mL);0.13(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);38.13(Max Conc. mM)
Ethanol:52.5(Max Conc. mg/mL);66.73(Max Conc. mM)
Water:24.36(Max Conc. mg/mL);30.96(Max Conc. mM) | | form | powder | | pka | 8.43±0.20(Predicted) | | color | White-beige | | BRN | 4778612 | | Stability: | Hygroscopic | | InChIKey | FSBUXLDOLNLABB-ISAKITKMSA-N | | LogP | 0.140 (est) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | LZ5786500 | | HS Code | 29389090 |
| | ECHINACOSIDE Usage And Synthesis |
| Description | Echinacoside is a phenylethanoid glycoside that has been found in Echinacea and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals (EC50 = 6.6 μM in a cell-free assay). Echinacoside (10 μg/ml) inhibits hydrogen peroxide-induced production of reactive oxygen species (ROS) and apoptosis in PC12 cells. It reduces increases in plasma alanine aminotransferase (ALT), TNF-α, IL-1β, IL-16, and IL-10 levels and hepatocyte apoptosis induced by LPS/D-galactosamine in a mouse model of acute liver injury when administered at a dose of 60 mg/kg. Echinacoside (20 mg/kg per day for 15 days) prevents loss of dopaminergic neurons in the substantia nigra pars compacta and decreases in striatal dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in a mouse model of MPTP-induced Parkinson''s disease. It also improves motor performance in the rotarod test in the same model. | | Chemical Properties | White powder | | Uses | Echinacoside Ethanolate is a caffeic acid glycoside, known for its neuroprotective, antiinflammatory and anti-oxidative activities. Also an anti[proliferative towards hypoxia influenced pulmonary artery smooth muscle cells. | | Definition | ChEBI: Echinacoside is an oligosaccharide. |
| | ECHINACOSIDE Preparation Products And Raw materials |
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