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| | 2-Benzothiazolamine Basic information |
| | 2-Benzothiazolamine Chemical Properties |
| Melting point | 126-129 °C (lit.) | | Boiling point | 190-195 °C(Press: 0.05 Torr) | | density | 1.2162 (rough estimate) | | refractive index | 1.5500 (estimate) | | storage temp. | Store below +30°C. | | solubility | Soluble in alcohol, chloroform, diethyl ether. | | form | Powder or Flakes | | pka | pK1: 4.48(+1) (20°C) | | color | Beige to grayish | | Water Solubility | <0.1 g/100 mL at 19 ºC | | Merck | 14,424 | | BRN | 116315 | | CAS DataBase Reference | 136-95-8(CAS DataBase Reference) | | NIST Chemistry Reference | Benzothiazole, 2-amino-(136-95-8) | | EPA Substance Registry System | 2-Aminobenzothiazole (136-95-8) |
| | 2-Benzothiazolamine Usage And Synthesis |
| Chemical Properties | BEIGE TO GREYISH POWDER OR FLAKES | | Uses | An impurity of pramipexole production | | Uses | 2-Aminobenzothiazole was used in the synthesis of cobalt(II) picrate mixed-ligand complexes. It was used to study adsorption of biologically significant 2-aminobenzothiazole molecules on colloidal silver particles using surface-enhanced raman scattering spectroscopy. | | Definition | ChEBI: 2-aminobenzothiazole is a member of benzothiazoles. | | General Description | Odorless gray to white powder. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | An amine, organosulfide. Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. | | Fire Hazard | Flash point data for 2-Benzothiazolamine are not available; however, 2-Benzothiazolamine is probably combustible. | | Biochem/physiol Actions | 2-Aminobenzothiazole has local anaesthetic action and has numerous applications in human and veterinary medicine. | | Purification Methods | The thiazole cystallises from a H2O, aqueous EtOH, *C6H6 or pet ether. The hydrochloride crystallises from dilute HCl and has m 240.5o. [Beilstein 27 H 182, 27 III/IV 4824.] |
| | 2-Benzothiazolamine Preparation Products And Raw materials |
| Raw materials | Disulfur dichloride-->1-PHENYL-2-THIOUREA | | Preparation Products | 2-Bromo-1,3-benzothiazole-->Cationic Brilliant Blue RL-->(2S,3R)-(+)-3-Isopropyl-2-phenyl-3,4-dihydro-2H-pyrimido[2,1-b][1,3]benzothiazole98+%-->2-IODOBENZOTHIAZOLE-->2-Amino-6-nitrobenzothiazole-->2,2'-Diaminodiphenyl disulphide-->2-Chlorobenzothiazole-->3-[[4-[(Benzothiazol-2-yl)azo]-3-methylphenyl](2-hydroxyethyl)amino]propanenitrile-->C.I. Basic Red 53-->Basic Blue 53-->N-(1,3-benzothiazol-2-yl)-2,5-dichlorobenzenesulfonamide-->2-PHENYLIMIDAZO[2,1-B][1,3]BENZOTHIAZOLE |
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