Antide

Antide Basic information

Product Name:	Antide
Synonyms:	iturelix;Ac-D-2-Nal-4-chloro-D-Phe-beta-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2;AC-DNAL-D: P-CLPHE-DPAL-SER-LYS: NICOTINOYL-DLYS: NICOTINOYL-LEU-LYS: ISOPROPYL-PRO-DALA-NH2;Brn 4866881;D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N(sup 6)-(3-pyridinylcarbonyl)-L-lysyl-N(sup 6)-(3-pyridinylcarbonyl)-D-lysyl-L-leucyl-N(sup 6)-(1-methylethyl)-L-lysyl-L-prolyl-;D-Alaninamide, N-acetyl-3-(2-naphthalenyl)-D-alanyl-4-chloro-D-phenylalanyl-3-(3-pyridinyl)-D-alanyl-L-seryl-N6-(3-pyridinylcarbonyl)-L-lysyl-N6-(3-pyridinylcarbonyl)-D-lysyl-L-leucyl-N6-(1-methylethyl)-L-lysyl-L-prolyl-;Orf 23541;Ac-D-2-Nal-4-chloro-D-Phe-b-(3-pyridyl)-D-Ala-Ser-Lys(nicotinoyl)-D-Lys(nicotinoyl)-Leu-Lys(isopropyl)-Pro-D-Ala-NH2
CAS:	112568-12-4
MF:	C82H108ClN17O14
MW:	1591.29
EINECS:
Product Categories:	hormones;Peptide;LH-RH;LH-RHPeptides for Cell Biology;Neuropeptides;Releasing Factors
Mol File:	112568-12-4.mol

Antide Chemical Properties

Boiling point	1798.0±65.0 °C(Predicted)
density	1.258±0.06 g/cm3(Predicted)
storage temp.	−20°C
form	Solid
pka	12.78±0.46(Predicted)
color	White to off-white
InChI	InChI=1S/C82H108ClN17O14/c1-50(2)41-65(76(108)95-64(26-11-12-37-88-51(3)4)82(114)100-40-18-27-70(100)81(113)91-52(5)71(84)103)96-75(107)63(25-10-14-39-90-73(105)60-23-17-36-87-48-60)93-74(106)62(24-9-13-38-89-72(104)59-22-16-35-86-47-59)94-80(112)69(49-101)99-79(111)68(45-56-19-15-34-85-46-56)98-78(110)67(43-54-29-32-61(83)33-30-54)97-77(109)66(92-53(6)102)44-55-28-31-57-20-7-8-21-58(57)42-55/h7-8,15-17,19-23,28-36,42,46-48,50-52,62-70,88,101H,9-14,18,24-27,37-41,43-45,49H2,1-6H3,(H2,84,103)(H,89,104)(H,90,105)(H,91,113)(H,92,102)(H,93,106)(H,94,112)(H,95,108)(H,96,107)(H,97,109)(H,98,110)(H,99,111)/t52-,62+,63-,64+,65+,66-,67-,68-,69+,70+/m1/s1
InChIKey	QRYFGTULTGLGHU-NBERXCRTSA-N
SMILES	C(N)(=O)[C@@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCNC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CCCCNC(C1=CC=CN=C1)=O)NC(=O)[C@H](CCCCNC(C1=CC=CN=C1)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC1=CC=CN=C1)NC(=O)[C@@H](CC1=CC=C(Cl)C=C1)NC(=O)[C@@H](CC1=CC=C2C(=C1)C=CC=C2)NC(C)=O

Safety Information

Hazard Codes	T
Risk Statements	60
Safety Statements	53-22-36/37/39-45
WGK Germany	3
RTECS	AY2961700
HS Code	3504009000

MSDS Information

Provider	Language
SigmaAldrich	English

Antide Usage And Synthesis

Uses	Reversible inhibition of gonadotropin secretion and subsequent suppression of ovarian and testicular steroid secretio (gonadotropin releasing hormone antagonist).
Uses	Antide, is a GnRH and LH-RH antagonist, and with high anti-ovulatory and negligible histamine release activity.

Antide Preparation Products And Raw materials

Raw materials

BOC-D-4-Chlorophe-->(R)-N-Boc-(3-Pyridyl)alanine-->Boc-3-(2-Naphthyl)-D-alanine

3-Pyridineethaneamine H-GLY-LEU-NH2 HCL p-Chloroamphetamine H-NLE-NH2 HCL 1-(N-ACETYLAMINO)-2-(4-CHLOROPHENYL)-ETHANE H-D-PHE-NH2 HCL AC-LYS-NH2 HCL H-PRO-GLY-NH2 HCL DL-NORLEUCINE AMIDE HYDROCHLORIDE 1-METHYL-2-PYRIDIN-4-YL-ETHYLAMINE H-ALA-ALA-ALA-NH2 HCL H-D-ALA-GLY-NH2 HCL N,N-DIETHYL-2-(METHYLAMINO)ACETAMIDE HYDROCHLORIDE 2-AMINO-1-PYRROLIDIN-1-YL-ETHANONE HCL L-Leucinamide hydrochloride H-ALA-PRO-NH2 HCL L-Serinamide hydrochloride (R)-(-)-2-AMINOBUTANAMIDE HYDROCHLORIDE, 97%

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