ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Piperazine compounds Levodropropizine

Levodropropizine

Levodropropizine Basic information
Product Name:Levodropropizine
Synonyms:(S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol;(2S)-3-(4-Phenyl-1-piperazinyl)-1,2-propanediol;Danka;l-Dropropizine;Levotuss;LVDP;Levodropropizine;(S)-3-(4-Phenylpiperazin-1-yl)propane-1,2-diol
CAS:99291-25-5
MF:C13H20N2O2
MW:236.31
EINECS:640-087-8
Product Categories:raw materials;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;99291-25-5
Mol File:99291-25-5.mol
Levodropropizine Structure
Levodropropizine Chemical Properties
Melting point 98-100°C
Boiling point 412.7±34.0 °C(Predicted)
density 1.168±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility Slightly soluble in water, freely soluble in dilute acetic acid and in methanol, slightly soluble in ethanol (96 per cent).
pka14.21±0.20(Predicted)
form neat
color White to Almost white
InChIInChI=1S/C13H20N2O2/c16-11-13(17)10-14-6-8-15(9-7-14)12-4-2-1-3-5-12/h1-5,13,16-17H,6-11H2/t13-/m0/s1
InChIKeyPTVWPYVOOKLBCG-ZDUSSCGKSA-N
SMILESC(O)[C@@H](O)CN1CCN(C2=CC=CC=C2)CC1
CAS DataBase Reference99291-25-5(CAS DataBase Reference)
Safety Information
HS Code 2933.59.5300
MSDS Information
Levodropropizine Usage And Synthesis
Chemical PropertiesWhite Solid
UsesS-Form of Dropropizine. Cough suppressive phenylpiperazine derivative. Antitussive.
UsesCough Suppressant
DefinitionChEBI: A member of the class of N-arylpiperazines that is N-phenylpiperazine in which the amino hydrogen is replaced by a 2,3-dihydroxypropyl group (the S-enantiomer). A peripherally acting antitussive drug t at is used as an alternative to opioids.
Levodropropizine Preparation Products And Raw materials
(S)-Lansoprazole Levocetirizine amide impurity HCl R-(+)-Lansoprazole (S)-(+)-Ketoprofen D(+)-Carnitine 4-[(1R)-1-(2,3-Dimethylphenyl)ethyl]-1H-imidazole monohydrochloride Hydroxypropyl cellulose LEVODROPROPIZINE IMPURITY A Levodropropizine N-Aminoethylpiperazine (R)-1-TOSYLOXY-2,3-PROPANEDIOL (LEVODROPROPIZINE INTERMEDIATE) 2-METHYL-1,3-PROPANEDIOL Diprophylline Levodropropizine (R)-(-)-1,2-Propanediol 1-phenylpiperazine (intermediate of levodropropizine) Dropropizine trans-1-Cinnamylpiperazine
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