(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid

(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Basic information

Product Name:	(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid
Synonyms:	(R)-(+)-MTPA,(R)-(+)-Mosher'sacid;(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid, 99%(e.e.>99.5%);(+)--Methoxy--(trifluoromethyl)phenylaceticacid(Moshersacid);(r)-(+)-à-methoxy-à-(trifluoromethyl)phenylacetic acid;(R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid 99% (99%ee);(R)-(+)-1-Methoxy-1-(trifluoromethyl)phenylacetic acid (99%ee);(R)-(+)-ɑ-Methoxy-ɑ-(trifluoromethyl)phenylacetic acid, 99%;(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic Acid [Optical Resolving]
CAS:	20445-31-2
MF:	C10H9F3O3
MW:	234.17
EINECS:	243-829-5
Product Categories:	Analytical Chemistry;e.e. / Absolute Configuration Determination (NMR);Enantiomer Excess & Absolute Configuration Determination
Mol File:	20445-31-2.mol

(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Chemical Properties

Melting point	46-49 °C(lit.)
alpha	D25 +68.5 ± 1.3° (c = 1.49 in CH3OH)
Boiling point	105-107 °C1 mm Hg(lit.)
density	1.344 g/mL at 25 °C(lit.)
refractive index	n20/D 1.473(lit.)
Fp	>230 °F
storage temp.	2-8°C
solubility	Soluble in methanol (50 mg/ 1 ml).
pka	1.47±0.10(Predicted)
form	Crystalline Low Melting Solid
color	White
Specific Gravity	1.344
optical activity	[α]20/D +73±1°, c = 2% in methanol
Sensitive	Hygroscopic
Merck	14,6280
BRN	2215440
CAS DataBase Reference	20445-31-2(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
F	3-10
Hazard Note	Irritant/Keep Cold
HazardClass	IRRITANT, HYGROSCOPIC, KEEP COLD
HS Code	29189900

MSDS Information

(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Usage And Synthesis

Chemical Properties	white crystalline low melting solid
Uses	(R)-(+)-alpha-Methoxy-alpha-(trifluoromethyl)phenylacetic acid is widely used reagent for determination of optical purities of alcohols and amines by 1H or 19F NMR.
Uses	Mosher′s acid chloride is used as a dervatization agent for β-arylethylamines, enantiomeric alcohols, and enantiomeric amines. It is also a reagent used for the determination of enantiomeric purity and absolute configuration of alcohols and amines by NMR.
General Description	Mosher′s acid chloride is generally used as a chiral derivatizing agent. It is easily available in enantiomerically pure form. It can form diastereomers with both alcohols and amines.
Purification Methods	A likely impurity is phenylethylamine from the resolution. Dissolve the acid in Et2O/*benzene (3:1), wash with 0.5N H2SO4, then water, dry over magnesium sulfate, filter, evaporate and distil it. [Dale et al. J Org Chem 34 2543 1969, J Am Chem Soc 75 512 1973.]

(R)-(+)-alpha-Methoxy-alpha-trifluoromethylphenylacetic acid Preparation Products And Raw materials

Preparation Products

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