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Timosaponin A-III

Timosaponin A-III Basic information
Product Name:Timosaponin A-III
Synonyms:[(25S)-5β-Spirostan-3β-yl]2-O-(β-D-glucopyranosyl)-β-D-galactopyranoside;Timosaponin A-III;TIMOSAPONIN A3 (SYN. TIMOSAPONIN A-III);TIMOSAPONIN A-3;TIMOSAPONIN A-;AnemarsaponinA3;Filiferin B;XilingsaponinA
CAS:41059-79-4
MF:C39H64O13
MW:740.92
EINECS:
Product Categories:chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;The group of Anemarrhenae
Mol File:41059-79-4.mol
Timosaponin A-III Structure
Timosaponin A-III Chemical Properties
Melting point 317-322 °C
Boiling point 862.8±65.0 °C(Predicted)
density 1.36±0.1 g/cm3(Predicted)
solubility DMF: 30 mg/ml; DMSO: 30 mg/ml
form White to off white solid.
pka12.85±0.70(Predicted)
Safety Information
MSDS Information
Timosaponin A-III Usage And Synthesis
UsesTimosaponin A3 suppresses certain human tumor processes and has the potential to be developed as an anticancer agent. Reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway. Induction of mitochondrial-dependent apoptosis in HepG2 human hepatocellular carcinoma cells.Timosaponin A3 is a potent inhibitor of U46619, that induces rat platelet aggregation and exhibited superior selectivity for the TP receptor vs. other G protein-coupled receptors and a PKC activator.
Timosaponin A-III Preparation Products And Raw materials
(R,10E)-4,8,9,12-Tetrahydro-3,11-dimethyl-6H-4,7-methenofuro[3,2-c]oxacycloundecin-6-one Anemarsaponin C DARUTIGENOL pseudoprototimosaponin AIII Baicalin Anemarsaponin E SESAMOLIN Anemarrhenasaponin A2 Sarsasapogenin Timosaponin BII Anemarrhenasaponin-Ia Sarsasapogenin 3-O-β-D-galactopyranosid Ginsenoside Rh2 Escin sodium Timosaponin A-III Ginsenosides N-OCTYL-BETA-D-GLUCOPYRANOSIDE TIMOSAPONIN A III
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