ChemicalBook Product Catalog Biochemical Engineering Polypeptide H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH

H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH

H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH Basic information
Product Name:H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH
Synonyms:ANGIOTENSIN 1/2 (1-9);ANGIOTENSIN (1-9);ANGIOTENSIN I (1-9);H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH;H2N-DRVYIHPFH-OH;DRVYIHPFH;Des-Leu angiotensin I【human】;L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro-L-Phe-L-His-OH
CAS:34273-12-6
MF:C56H78N16O13
MW:1183.32
EINECS:
Product Categories:SignalTransduction;peptide
Mol File:34273-12-6.mol
H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH Structure
H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH Chemical Properties
density 1.46±0.1 g/cm3(Predicted)
storage temp. -15°C
solubility ≥118.3 mg/mL in DMSO; insoluble in EtOH; ≥51 mg/mL in H2O
form solid
pka2.91±0.10(Predicted)
Safety Information
HS Code 29371900
MSDS Information
H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH Usage And Synthesis
Chemical PropertiesWhite powder
DefinitionChEBI: Angiotensin (1-9) is a nine amino acid peptide which is formed when angiotensin converting enzyme 2 (ACE2) hydrolyzes the carboxy terminal leucine from angiotensin I. It is a anti-cardiac hypertrophy agent. It has a role as a human metabolite, a rat metabolite, an antihypertensive agent and a cardioprotective agent. It is a tautomer of an angiotensin (1-9) dizwitterion.
Biological Activityangiotensin i/ii (1-9) is a peptide (asp-arg-val-tyr-ile-his-pro-phe-his) containing the amino acids 1-9 that are converted from angiotensin i/ii peptide.angiotensin i is formed by the action of renin on angiotensinogen, which has 12 amino acids and is an α-2-globulin produced constitutively and released into the circulation mainly by the liver. renin cleaves the peptide bond between the leucine (leu) and valine (val) residues on angiotensinogen, creating the ten-amino acid peptide angiotensin i. angiotensin i is converted to angiotensin ii (aii) through removal of two c-terminal residues by the enzymeangiotensin-converting enzyme (ace), primarily through ace within the lung.angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. angiotensin also stimulates the release of aldosterone, which promotes sodium retention in the distal nephron so that drives blood pressure up.figure1 formula of angiotensin i/ii (1-9)
references1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246–9. 2. Richard A. Preston. et. (1998). “Age-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapy”. JAMA. 1998;280(13):1168-1172.3. Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL. Harrison's principles of internal medicine. McGraw-Hill Medical.
H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH Preparation Products And Raw materials
H-ARG-PRO-PRO-GLY-PHE-SER-PRO-OH ACETATE SALT ANGIOTENSIN II, HUMAN ANGIOTENSIN I/II (4-8) H-MET-LYS-ARG-SER-ARG-GLY-PRO-SER-PRO-ARG-ARG-OH ANGIOTENSIN III, HUMAN Angiotensin acetate ANGIOTENSIN I/II (1-6) ABZ-GLY-4-NITRO-PHE-PRO-OH BZ-GLY-GLY-GLY-OH MYOGLOBIN FROM HORSE SKELETAL MUSCLE* ANGIOTENSIN I, 1-9 TFA H-GLY-HIS-OH Angiotensin N-Acetyl-DL-histidine, Hydrate H-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-OH N-Acetyl-L-histidine H-ALA-HIS-OH H-GLY-GLY-HIS-OH H2O
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