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| | Wogonin Basic information |
| | Wogonin Chemical Properties |
| Melting point | 203-206°C | | Boiling point | 518.8±50.0 °C(Predicted) | | density | 1.420±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | DMSO: ≥20mg/mL | | form | Yellow solid | | pka | 6.83±0.40(Predicted) | | color | Light Yellow to Yellow | | λmax | 319nm(EtOH)(lit.) | | InChIKey | XLTFNNCXVBYBSX-UHFFFAOYSA-N | | LogP | 2.140 (est) | | CAS DataBase Reference | 632-85-9(CAS DataBase Reference) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | RTECS | LK8331000 | | HS Code | 29329990 |
| | Wogonin Usage And Synthesis |
| Uses | Wogonin acts as an anti-inflammatory agent, attenuating ovalbumin antigen-influenced neutrophillic airway inflammation. In addition, it reverses multi-drug resistance of human myelogenous leukemia. | | Definition | ChEBI: A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8. | | General Description | Wogonin is a flavonoid component of Scutellaria baicalensis Georgi roots. | | Biochem/physiol Actions | Wogonin is an anti-inflammatory agent and COX-2 inhibitor, which inhibits the induction of both iNOS and COX-2. Wogonin inhibits COX-2 (IC50 = 46 μM) without affecting COX-1. Wogonin inhibits iNOS induction and thus inhibts activation-induced C6 glial cell death. Specifically, Wogonin inhibits NF-kappaB-mediated iNOS induction. | | storage | Dry, dark and at 0 - 4 ℃ for short term (days to weeks) or -20 ℃ for long term (months to years). |
| | Wogonin Preparation Products And Raw materials |
| Raw materials | 4H-1-Benzopyran-4-one, 7-hydroxy-5,8-dimethoxy-2-phenyl--->4H-1-Benzopyran-4-one, 2,3-dihydro-5,7-dihydroxy-8-methoxy-2-phenyl-, (2S)--->4H-1-Benzopyran-4-one, 5,8-dihydroxy-2-phenyl-7-(phenylmethoxy)--->3,4,5-Trimethoxyphenol-->Chrysin-->2,3,4-TRIMETHOXY-6-HYDROXYACETOPHENONE-->Cinnamoyl chloride | | Preparation Products | Oroxylin A-->5-Hydroxy-7-acetoxy-8-methoxyflavone |
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