| | 2-Methoxy-5-methylaniline Basic information |
| | 2-Methoxy-5-methylaniline Chemical Properties |
| Melting point | 50-52 °C (lit.) | | Boiling point | 235 °C (lit.) | | density | 1.0252 (rough estimate) | | vapor density | 4.7 (vs air) | | vapor pressure | 2.6Pa at 20℃ | | refractive index | 1.5647 (estimate) | | Fp | >230 °F | | storage temp. | Room Temperature, under inert atmosphere | | solubility | Chloroform (Slightly), Ethyl Acetate, Methanol (Slightly) | | pka | 4.66±0.10(Predicted) | | form | Crystalline Chunks | | color | Brown to black | | Water Solubility | Slightly soluble in hot water. | | BRN | 637071 | | Stability: | Air Sensitive | | InChIKey | WXWCDTXEKCVRRO-UHFFFAOYSA-N | | LogP | 1.65 at 23℃ and pH7 | | CAS DataBase Reference | 120-71-8(CAS DataBase Reference) | | IARC | 2B (Vol. 27, Sup 7) 1987 | | NIST Chemistry Reference | Benzenamine, 2-methoxy-5-methyl-(120-71-8) | | EPA Substance Registry System | p-Cresidine (120-71-8) |
| Hazard Codes | T,Xi | | Risk Statements | 45-22 | | Safety Statements | 53-45 | | WGK Germany | 3 | | RTECS | BZ6720000 | | F | 9 | | HazardClass | IRRITANT | | HS Code | 29222990 | | Hazardous Substances Data | 120-71-8(Hazardous Substances Data) | | Toxicity | rat,LD50,oral,1450mg/kg (1450mg/kg),Huntingdon Research Center Reports. Vol. -, Pg. -, 1972. |
| | 2-Methoxy-5-methylaniline Usage And Synthesis |
| Chemical Properties | brown to black crystalline chunks | | Chemical Properties | p-Cresidine is a white crystalline solid. | | Uses | p-Cresidine is a reagent used in the preparation of enaminones acting as anticonvulsants. Also used in the preparation of crescent oligoamides. Dyes and metabolites, Environmental Testing. | | Uses | 2-Methoxy-5-methylaniline was used in the synthesis of 4-(4-Amino-5-methoxy-2-methylphenylazo)-5-hydroxy-naphthalene-2,7-disulfonic acid. 2-Methoxy-5-methylaniline was used to analyse the application of polymeric ionic liquids as selective solid-phase microextraction sorbent coatings for the analysis of genotoxic impurities and structurally alerting compounds such as alkyl halides and aromatics. 2-Methoxy-5-methylaniline was used in a study to develop a sensitive analytical method for the determination of aromatic amines found in commercial hair dyes using high liquid chromatography coupled to an electrochemical detector by using the ionic liquid 1-butyl-3-methylimidazolium bis(trifluoromethanesulfonyl)imide in the mobile phase. | | Definition | ChEBI: Para-Cresidine is a member of methoxybenzenes. | | General Description | White to silver-gray odorless crystals. | | Air & Water Reactions | Insoluble in water. | | Reactivity Profile | 2-Methoxy-5-methylaniline is sensitive to moisture and temperatures greater than 104°F. Incompatible with strong oxidizing agents . | | Hazard | A possible carcinogen. | | Fire Hazard | 2-Methoxy-5-methylaniline is nonflammable. | | Safety Profile | Confirmed carcinogen
with experimental carcinogenic and
neoplastigenic data. Moderately toxic by
ingestion. A skin and eye irritant. Mutation
data reported. When heated to
decomposition it emits toxic fumes of NOx.
See also ESTERS. | | Potential Exposure | p-Cresidine is used as an intermediate in the production of various azodyes, printing inks, and pigments; including 11 dyes that are produced commercially in the United States. Human exposure to p-Cresidine occurs primarily through inhalation of | | Carcinogenicity | p-Cresidine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. | | Shipping | UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required | | Incompatibilities | Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. |
| | 2-Methoxy-5-methylaniline Preparation Products And Raw materials |
| Raw materials | Sodium hydroxide-->Dimethyl sulfate-->Sodium sulfide-->4-Chlorotoluene-->4-Chloro-2-nitrotoluene-->4-Methylanisole-->4-Chloro-3-nitrotoluene-->N-BENZYLDIETHYLAMINE-->(4-methoxy-3-nitrophenyl)methylene diacetate-->2-azido-1-methoxy-4-methylbenzene-->4-Chloro-2-methoxy-5-methylaniline-->4-Methyl-2-nitroanisole-->2-Nitro-p-cresol-->Hydrochloric acid | | Preparation Products | Direct Blend Blue-->Direct Blending Yellow D-3RNL-->Reactive Yellow 84-->Direct Green 26-->Direct Violet 9-->tetrasodium 3,3'-[(1,6-dihydro-6-oxo-1,3,5-triazine-2,4-diyl)bis[imino(5-methoxy-2-methyl-4,1-phenylene)azo]]bis(naphthalene-1,5-disulphonate)-->Direct Grey D-->DIRECT VIOLET 51-->tetrasodium 4,4'-[carbonylbis[imino(5-methoxy-2-methyl-4,1-phenylene)azo]]bis[5-hydroxynaphthalene-2,7-disulphonate]-->trisodium 4-hydroxy-5-[[4-[[1-hydroxy-6-(phenylamino)-3-sulphonato-2-naphthyl]azo]-5-methoxy-2-methylphenyl]azo]naphthalene-2,7-disulphonate-->Direct Yellow L-5R-->4-Amino-5-methoxy-2-methylbenzensulfonic acid-->DIRECT GREEN 26-->DISPERSE BLACK 2 |
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