Neferine

Neferine Basic information
Product Name:Neferine
Synonyms:Phenol,4-[[(1S)-1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl-1-isoquinolinyl]Methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2-Methyl-7-isoquinolinyl]oxy]-;4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol;4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;Neferin;NEFERINE;4''-O-Methylliensinine;Methylliensinine
CAS:2292-16-2
MF:C38H44N2O6
MW:624.77
EINECS:
Product Categories:reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;chemical reagent;pharmaceutical intermediate;phytochemical
Mol File:2292-16-2.mol
Neferine Structure
Neferine Chemical Properties
Melting point 59-61 °C
Boiling point 710.9±60.0 °C(Predicted)
density 1.185±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: >15mg/mL
form powder
pka9.28±0.45(Predicted)
color white to beige
optical activity[α]/D -34 to -44° (c=0 3. CHCl3)
InChIKeyMIBATSHDJRIUJK-ROJLCIKYSA-N
Safety Information
WGK Germany 3
RTECS SM9495000
MSDS Information
Neferine Usage And Synthesis
DescriptionA bisbenzylisoquinoline alkaloid from Nelumbo nucifera, the structure of this base has been shown to be that represented above based upon chemical degrada_x0002_tive studies and spectroscopic data. Four methoxyl groups, one hydroxyl and two methylimino groups are present.
UsesNeferine is an isoquinoline alkaloid which enhances the antitumor effect of Mitomycin-C in hela cells through activation of p38-MAPK. Useful in the treatment of cervical cancers.
DefinitionChEBI: Neferine is a member of isoquinolines.
Biochem/physiol ActionsNeferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.
ReferencesYang, Chen.,J. Chin. Chem. Soc., 17,235 (1970)
Neferine Preparation Products And Raw materials
Vincristine 3,4-Dihydroxyphenylethanol Aloe emodin 13,14-Didehydromatridin-15-one Vincristine sulfate Methylparaben Methyl Bensulfuron methyl Parathion-methyl Isoliensinine Neferine Kresoxim-methyl Thiophanate-methyl Methyl acrylate Methyl acetate Liensinine Methyl bromide METSULFURON METHYL

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