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| | Neferine Basic information |
| Product Name: | Neferine | | Synonyms: | Phenol,4-[[(1S)-1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl-1-isoquinolinyl]Methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2-Methyl-7-isoquinolinyl]oxy]-;4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol;4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol;4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol;Neferin;NEFERINE;4''-O-Methylliensinine;Methylliensinine | | CAS: | 2292-16-2 | | MF: | C38H44N2O6 | | MW: | 624.77 | | EINECS: | | | Product Categories: | reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;chemical reagent;pharmaceutical intermediate;phytochemical | | Mol File: | 2292-16-2.mol |  |
| | Neferine Chemical Properties |
| Melting point | 59-61 °C | | Boiling point | 710.9±60.0 °C(Predicted) | | density | 1.185±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: >15mg/mL | | form | powder | | pka | 9.28±0.45(Predicted) | | color | white to beige | | optical activity | [α]/D -34 to -44° (c=0 3. CHCl3) | | InChIKey | MIBATSHDJRIUJK-ROJLCIKYSA-N |
| WGK Germany | 3 | | RTECS | SM9495000 |
| | Neferine Usage And Synthesis |
| Description | A bisbenzylisoquinoline alkaloid from Nelumbo nucifera, the structure of this base has been shown to be that represented above based upon chemical degrada_x0002_tive studies and spectroscopic data. Four methoxyl groups, one hydroxyl and
two methylimino groups are present. | | Uses | Neferine is an isoquinoline alkaloid which enhances the antitumor effect of Mitomycin-C in hela cells through activation of p38-MAPK. Useful in the treatment of cervical cancers. | | Definition | ChEBI: Neferine is a member of isoquinolines. | | Biochem/physiol Actions | Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1. | | References | Yang, Chen.,J. Chin. Chem. Soc., 17,235 (1970) |
| | Neferine Preparation Products And Raw materials |
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