2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID

2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Basic information
Product Name:2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID
Synonyms:(o-(2,6-dichloro-4-hydroxyanilino)phenyl)-aceticaci;(o-(2,6-dichloro-4-hydroxyanilino)phenyl)aceticacid;DICLOFENAC, 4'-HYDROXY-;4'-OHD;4-OHD;4-HYDROXY DICLOFENAC;4'-HYDROXYDICLOFENAC;2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID
CAS:64118-84-9
MF:C14H11Cl2NO3
MW:312.15
EINECS:626-698-2
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:64118-84-9.mol
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Structure
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Chemical Properties
Melting point 178-185°C dec.
Boiling point 432.7±45.0 °C(Predicted)
density 1.520±0.06 g/cm3(Predicted)
Fp 2℃
storage temp. -20°C
solubility Soluble in DMSO, ethanol or methanol
pka4.17±0.10(Predicted)
form neat
BRN 4198042
Stability:Light Sensitive
Safety Information
Hazard Codes T,N,Xn,F
Risk Statements 25-37/38-41-50/53-36-20/21/22-11
Safety Statements 26-39-45-60-61-36/37-16
RIDADR UN 2811 6.1/PG 3
WGK Germany 3
RTECS AG6542800
HazardClass 6.1
MSDS Information
ProviderLanguage
SigmaAldrich English
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Usage And Synthesis
Description4-hydroxy Diclofenac is a CYP2C9 metabolite of the NSAID diclofenac . By inhibiting COX and subsequently suppressing PGE2 synthesis, it demonstrates anti-inflammatory and analgesic properties.
Chemical PropertiesLight Violet Solid
UsesA metabolite of Diclofenac, a nonsteroidal inflammatory compound and cyclooxygenase (COX) inhibitor.
UsesA metabolite of Diclofenac, a nonsteroidal anti-inflammatory compound and cyclooxygenase (COX) inhibitor
UsesA Cytochrome P450 2C9 (CYP2C9) metabolite of diclofenac
DefinitionChEBI: An monocarboxylic acid that is the 4'-hydroxylated metabolite of diclofenac.
General Description4′-Hydroxydiclofenac is one of the metabolites of diclofenac, a nonsteroidal anti-inflammatory drug (NSAID) used in human and veterinary medicine.
2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID Preparation Products And Raw materials
2-(2-Bromo-6-chlorophenyl)amino)-phenylacetic acid sodium salt 95% Diclofenac Impurity 16 (2-(2,6-DICHLOROANILINO)PHENYL) METHANOL Diclofenac Impurity 7 1-(2,6-Dichlorophenyl)indolin-2-one Diclofenac sodium 2,6-DICHLORODIPHENYLAMINE Oxindole 2-[(2,6-dichlorophenyl)amino]benzoicacid 2-(2,6-Dichloroanilino) benzaldehyde 4Hydroxy Diclofenac-D4 (Major) 1-(2,6-Dichlorophenyl)-2-indolinone 2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID 2-ANILINOPHENYLACETIC ACID 4-HYDROXY-2'-METHYLDIPHENYLAMINE 4-Amino-3-chlorophenol hydrochloride (2-(2,6-Dichloro-4-hydroxyanilino)-5-hydroxyphenyl)acetic acid Phenylacetic acid

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