4-Fluorobenzotrifluoride

4-Fluorobenzotrifluoride Basic information

Product Name:	4-Fluorobenzotrifluoride
Synonyms:	alpha,alpha,alpha,p-Tetrafluorotoluene;benzene,1-fluoro-4-(trifluoromethyl)-;p-(Trifluoromethyl)fluorobenzene;p-alpha,alpha,alpha-Tetrafluoro toluene;p-Fluorotrifluoromethylbenzene;Toluene, p,alpha,alpha,alpha-tetrafluoro-;toluene,p,α,α,α-tetrafluoro-;π,a,a,a-tetrafluorotoluene
CAS:	402-44-8
MF:	C7H4F4
MW:	164.1
EINECS:	206-944-1
Product Categories:	Fluorobenzene;Aromatic Hydrocarbons (substituted) & Derivatives;Trifluoromethylbenzene serise
Mol File:	402-44-8.mol

4-Fluorobenzotrifluoride Chemical Properties

Melting point	−42-−41.7 °C(lit.)
Boiling point	102-105 °C(lit.)
density	1.293 g/mL at 25 °C(lit.)
refractive index	n20/D 1.401(lit.)
Fp	51 °F
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Liquid
Specific Gravity	1.2930
color	Clear colorless
Water Solubility	Slightly soluble in water.
BRN	1909390
CAS DataBase Reference	402-44-8(CAS DataBase Reference)
NIST Chemistry Reference	Benzene, 1-fluoro-4-(trifluoromethyl)-(402-44-8)
EPA Substance Registry System	4-Fluorobenzotrifluoride (402-44-8)

Safety Information

Hazard Codes	F,Xi,F+
Risk Statements	11-36/37/38
Safety Statements	16-26-33-24/25-7/9
RIDADR	UN 1993 3/PG 2
WGK Germany	3
Hazard Note	Flammable/Irritant
TSCA	T
HazardClass	3
PackingGroup	II
HS Code	29039990

MSDS Information

Provider	Language
alpha,alpha,alpha,4-tetrafluorotoluene	English
SigmaAldrich	English
ACROS	English
ALFA	English

4-Fluorobenzotrifluoride Usage And Synthesis

Chemical Properties	Clear colourless to light yellow liquid
Uses	4-Fluorobenzotrifluoride was used in the synthesis of 2,2?-bis(trifluoromethylphenoxy)biphenyl via nucleophilic aromatic substitution reaction with 2,2?-biphenol, (S)-fluoxetine, potent inhibitor of neuronal serotonin-uptake and 1-aryloxy-2-substituted aminomethyltetrahydronaphthalene derivatives.
Synthesis Reference(s)	Tetrahedron, 49, p. 8129, 1993 DOI: 10.1016/S0040-4020(01)88032-7

4-Fluorobenzotrifluoride Preparation Products And Raw materials

Raw materials	Sodium nitrite-->p-Toluidine-->2-Fluorobenzotrifluoride-->3-Fluorobenzotrifluoride-->TRIETHOXY(4-(TRIFLUOROMETHYL)PHENYL)SIL&-->2,5-DIFLUOROBENZOTRIFLUORIDE-->4-Nitrobenzotrifluoride-->4-Trifluoromethylphenylboronic acid-->4-TRIFLUOROMETHYLPHENYLBORONIC ACID, PINACOL ESTER-->1-TrifluoroMethyl-1,2-benziodoxol-3(1H)-one
Preparation Products	2-FLUORO-5-(TRIFLUOROMETHYL)BENZOIC ACID-->4-(TRIFLUOROMETHYL)-BIPHENYL-->4-METHOXY-3-NITROBENZOTRIFLUORIDE-->(S)-Norfluoxetine-->2-FLUORO-5-(TRIFLUOROMETHYL)PHENYLBORONIC ACID-->2-Methoxy-5-(trifluoromethyl)aniline

Xylene 1,2,4-Trimethylbenzene Tosufloxacin tosylate Fluorine Benzotrifluoride 2-FLUOROBENZOTRIFLUORIDE,O-FLUOROBENZOTRIFLUORIDE OCTAFLUOROTOLUENE 3,4-Dichlorobenzotrifluoride 4-Fluorobenzotrifluoride 1,4-Bis(trifluoromethyl)-benzene Mesitylene 2-FLUORO-5-(TRIFLUOROMETHYL)BENZYL ALCOHOL TRITON Benzene 2-FLUORO-5-(TRIFLUOROMETHYL)BENZYLAMINE 2'-FLUORO-5'-(TRIFLUOROMETHYL)ACETOPHENONE 2-Methylbenzotrifluoride Diethylstilbestrol

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