Phosphorus oxybromide

Phosphorus oxybromide Basic information
Chemical properties Toxicity Application Preparation Category Flammability and Hazardous characteristics Storage characteristics warehouse Fire extinguishing agent
Product Name:Phosphorus oxybromide
Synonyms:Phosphorus oxybromide, 98+%;Phosphorus(V) tribromide oxide/ 98+%;Phosphorus(V) oxybro;Phosphorus(V) oxybroM;Phosphoryl TribroMide (Phosphorus oxybroMide);Formylmelphalan;Phosphoryl bromide for synthesis;phosphoryltribromide
CAS:7789-59-5
MF:Br3OP
MW:286.69
EINECS:232-177-7
Product Categories:metal oxyhalide
Mol File:7789-59-5.mol
Phosphorus oxybromide Structure
Phosphorus oxybromide Chemical Properties
Melting point 56 °C(lit.)
Boiling point 192 °C(lit.)
density 2.82 g/mL at 25 °C(lit.)
Fp 189°C
storage temp. Store below +30°C.
form Lump
Specific Gravity2.822
color White to yellow
Water Solubility decomposes
Sensitive Moisture Sensitive
Merck 14,7348
InChIKeyUXCDUFKZSUBXGM-UHFFFAOYSA-N
CAS DataBase Reference7789-59-5(CAS DataBase Reference)
NIST Chemistry ReferencePhosphorus tribromide oxide(7789-59-5)
EPA Substance Registry SystemPhosphoric tribromide (7789-59-5)
Safety Information
Hazard Codes C
Risk Statements 14-34-37
Safety Statements 26-36/37/39-43-45-7/8-Neverusewater.
RIDADR UN 1939 8/PG 2
WGK Germany 3
10-21
Hazard Note Corrosive
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 28129090
Hazardous Substances Data7789-59-5(Hazardous Substances Data)
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Phosphorus oxybromide Usage And Synthesis
Chemical propertiesIt appears as colorless or pale orange crystal with irritating odor. It has a relative density of 2.822, melting temperature of 56 °C, the boiling point of 191.7 ℃ and the evaporation heat of 38 Kj/mol. It is soluble in ether, benzene, chloroform, carbon disulfide, concentrated sulfuric acid. It can be slowly hydrolyzed to phosphoric acid and HBr in water.
ToxicityIt has similar toxicity to the phosphorus oxychloride. It can react with water, emitting a white smoke-like, irritant and corrosive hydrogen bromide gas which has strong irritation to the eyes, mucous membranes and skin. The patients having inhaled of the vapor or smoke should be sent away from the contaminated area for rest and keeping warm. If eyes are irritated, rinse with water. Upon severe cases, send for medical treatment. Upon skin contact, first rinse with water, and then thoroughly wash with soap. If burned, go for medical treatment. Upon mistakenly administration, immediately gargle and immediately go to the hospital for treatment.
ApplicationDuring the chemical process, it can be used as an intermediate and used as the raw materials for manufacturing the bromine flame retardant.
PreparationPhosphorus oxychloride method: take phosphorus oxychloride as raw material and aluminum trichloride as the catalyst, upon heating at about 80 ℃, introduce hydrogen bromide gas for reaction, generating tribromo phosphorus. The reaction is:
POC13 + 3HBr → POBr3 + 3HCl ↑
The produced hydrogen chloride gas during the reaction, after being absorbed by water, can produce dilute hydrochloric acid.
Phosphorus tribromide method: to a round bottom flask equipped with a reflow condenser, add the mixture of phosphorus pentabromide and phosphorus pentoxide (250 g of PBr5/about 30 g of P2O5) and heat slowly to 150 ° C. Phosphorus pentoxide is a bit more than the phosphorus pentabromide in stoichiometry. At this time, one the one hand, pay attention to expel the bromine out; on the other hand, make sure that the reaction is completed within 5h.
Then, 10 g of bromine and equivalent amount of phosphorus pentoxide were added to the melt and refluxed at 150 ° C for several hours. This is because it takes time for the intermediate product, phosphorus tribromide, to be oxidized to phosphorus pentabromide and transited to tribromonic phosphorus. The resultant was subjected to vacuum distillation under reduced pressure. After removing the initial distillate and the phosphorus tribromide contained therein, the trapping was carried out. The receiver is cooled with ice brine to generate tribromo phosphorus. Its reaction is:
3PBr5 + P2O5 → 5POBr3




Categorycorrosive items
Flammability and Hazardous characteristicsIt is subject to decomposition upon coming across water, generating toxic hydrogen bromide gas.
Storage characteristics warehouseventilated, low temperature and dry; it should be stored separately from combustible product.
Fire extinguishing agentDry powder
Chemical Propertiescolorless to grey-brown crystals or fused mass
UsesPhosphorus(V) Oxybromide is a reagent used in the preparation of phosphoryl halide for N-protection of amino acids using group assisted purification (GAP). Phosphorus(V) Oxybromide is a brominating agent.
UsesPhosphorus(V) oxybromide may be used as brominating reagent in the synthesis of 2,4,6-tribromopyrimidine. It may be used in the preparation of bromoheterocyclic compounds.
General DescriptionA colorless crystalline solid or liquid if heated above 133° F with a pungent odor. Phosphorus oxybromide is commonly heated and shipped in a molten state. Soluble in water, but, decomposed by water to hydrobromic and phosphoric acid with evolution of heat. Reacts with organic materials to cause fire. Evolves highly toxic and corrosive gases when exposed to fire. Corrosive to metals and tissue. Used to make other chemicals.
Reactivity ProfilePhosphorus oxybromide is incompatible with water, strong oxidizing agents, alcohols, bases, including amines. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health HazardCORROSIVE and/or TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Fire will produce irritating, corrosive and/or toxic gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control or dilution water may cause pollution.
Fire HazardEXCEPT FOR ACETIC ANHYDRIDE (UN1715), THAT IS FLAMMABLE, some of these materials may burn, but none ignite readily. May ignite combustibles (wood, paper, oil, clothing, etc.). Substance will react with water (some violently), releasing corrosive and/or toxic gases and runoff. Flammable/toxic gases may accumulate in confined areas (basement, tanks, hopper/tank cars, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water. Substance may be transported in a molten form.
Safety ProfilePoison by ingestion, inhalation, and shin contact. A corrosive irritant to skin, eyes, and mucous membranes. A corrosive material. Reacts with steam, water to produce much heat with toxic fumes. When heated to decomposition it emits very toxic fumes of Brand POx. See also BROMIDES.
Phosphorus oxybromide Preparation Products And Raw materials
Raw materialsHydrogen bromide-->Bifenthrin
Preparation ProductsThiazole-5-carboxaldehyde-->METHYL 5-BROMOPYRAZINE-2-CARBOXYLATE-->2-(TRIFLUOROMETHYL)-5,7-DIMETHYLQUINOLINE-4-CARBOXYLIC ACID-->3-Amino-2-bromopyridine-->2-Bromoquinoline-->2-BROMO-PYRIDIN-3-YLAMINE HCL-->2-BROMO-3-IODO-ISONICOTINIC ACID-->5-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID-->2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID-->2-Bromoquinoxaline-->5-Amino-2-bromopyridine-->2-Bromo-5-nitropyridine-->Thiazole-4-carboxaldehyde-->2-TRIFLUOROMETHYLQUINOLINE-->5-ACETAMIDO-2-BROMOPYRIDINE-->4-BROMOQUINOLIN-2(1H)-ONE-->3,3,3-Trifluoropropionic acid-->5-Bromothiophene-2-carbaldehyde-->6-Fluoro-4-(trifluoromethyl)quinoline-2-carboxylic acid ,97%-->6-BROMO-2,4-DIMETHOXYPYRIMIDINE-->6-CHLORO-2-(TRIFLUOROMETHYL)QUINOLINE-4-CARBOXYLIC ACID-->5-DIMETHYLAMINO-THIOPHENE-2-CARBALDEHYDE-->2-(TRIFLUOROMETHYL)-5-METHYLQUINOLINE-4-CARBOXYLIC ACID-->6-Bromopurine-->2-Bromo-4-nitroimidazole-->2,4-DIBROMOPYRIMIDINE-->1-(3-METHOXYPROPYL)-PIPERAZINE-->2-Bromo-3-nitropyridine-->2,6-BIS(TRIFLUOROMETHYL)-4-HYDROXYQUINOLINE-->4-bromo-2-(trifluoromethyl)quinoline-->2-CHLORO(BROMO)PYRIMIDINE-->2-BROMO-6-ETHOXYPYRIDINE-4-CARBOXYLIC ACID-->Pyridazine, 3-bromo- (9CI)-->4-BROMO-6-FLUORO-2-(TRIFLUOROMETHYL)QUINOLINE-->4-BROMO-PYRAN-2-ONE-->Pyrimidine, 4-bromo- (8CI,9CI)-->2,4-Dibromothiazole-->2-Bromo-5-nitro-4-picoline-->2,4,6-TRIBROMOPYRIMIDINE-->N-(2-BROMO-3-PYRIDINYL)ACETAMIDE
Phosphorus oxychloride Phosphorus tribromide Phosphorus Hexamethylphosphoramide Propionyl bromide PARAOXON ETHYLENE OXIDE (Diethoxymethyl)diphenylphosphine oxide Zinc oxide Phosphorus oxychloride Choline glycerophosphate Phosphorus oxybromide Clidinium bromide Dibutyryl adenosine cyclophosphate calcium Sodium bromate Ethidium bromide Profenofos Methyl bromide

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