ChemicalBook Product Catalog Organic Chemistry Organic fluorine compound Fluoroaniline series 4-Chloro-3-fluoroaniline

4-Chloro-3-fluoroaniline

4-Chloro-3-fluoroaniline Basic information
Uses
Product Name:4-Chloro-3-fluoroaniline
Synonyms:4-CHLORO-3-FLUORO-PHENYLAMINE;4-CHLORO-3-FLUOROANILINE;3-FLUORO-4-CHLOROANILINE;BUTTPARK 44\01-97;4-chloro-3-fluorobenzenaMine;4-Chloro-3-fluoroanline;4-Chloro-3-fluoroaniline 98%;4-Chloro-3-fluoroaniline98%
CAS:367-22-6
MF:C6H5ClFN
MW:145.56
EINECS:206-683-3
Product Categories:Aryl Fluorinated Building Blocks;Building Blocks;C6;Chemical Synthesis;Fluorinated Building Blocks;Organic Fluorinated Building Blocks;Other Fluorinated Organic Building Blocks;Anilines, Aromatic Amines and Nitro Compounds;Aniline
Mol File:367-22-6.mol
4-Chloro-3-fluoroaniline Structure
4-Chloro-3-fluoroaniline Chemical Properties
Melting point 61
Boiling point 226°C(lit.)
density 1.349±0.06 g/cm3(Predicted)
Fp 60 - 62°C
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility soluble in Methanol
pka2.94±0.10(Predicted)
form powder to crystal
color White to Gray to Red
BRN 2716278
CAS DataBase Reference367-22-6(CAS DataBase Reference)
Safety Information
Hazard Codes T,Xi
Risk Statements 20/21/22-36/37/38
Safety Statements 26-36/37/39-63-45-38
RIDADR UN2811
WGK Germany 3
Hazard Note Toxic
HazardClass 6.1
PackingGroup III
HS Code 29214200
MSDS Information
4-Chloro-3-fluoroaniline Usage And Synthesis
Uses4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate; a key intermediate towards phosphoindole inhibitors of HIV non-nucleoside reverse transcriptase. 4-Chloro-3-fluoroaniline is also used in the synthesis of 3-Deschloro-4-desfluoro-4-chloro-3-fluoro Gefitinib (D289540) which is an impurity of the tyrosine kinase inhibitor Gefitinib.
Chemical PropertiesWhite to light yellow solid
Uses4-Chloro-3-fluoroaniline is used in the synthesis of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate
4-Chloro-3-fluoroaniline Preparation Products And Raw materials
Preparation Products4-Chloro-2-fluoroaniline-->Ethanone,1-(2-amino-5-chloro-4-fluorophenyl)-
1-CHLORO-2-FLUORO-4-ISOTHIOCYANATO-BENZENE 1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)-1H-PYRROLE 2,4-Dichloro-5-fluoronitrobenzene 4-Chloro-2-Fluoroaniline/2-Fluoro-4-Chloroaniline/ RARECHEM AL FC 0004 2-[(4-CHLORO-3-FLUOROANILINO)METHYLIDENE]-4,4,4-TRIFLUORO-1-(2-THIENYL)BUTANE-1,3-DIONE 4-Bromo-2-chloro-6-fluoroaniline 3-(4-chloro-3-fluoroanilino)-1-(2-thienyl)-1-propanone N2-[4-CHLORO-2-(([3-CHLORO-5-(TRIFLUOROMETHYL)-2-PYRIDYL]CARBONYL)AMINO)-5-FLUOROPHENYL]-3-CHLORO-5-(TRIFLUOROMETHYL)PYRIDINE-2-CARBOXAMIDE 4-CHLORO-5-FLUORO-O-PHENYLENEDIAMINE 2,4-DICHLORO-3-FLUORONITROBENZENE N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)ACETAMIDE BUTTPARK 49\07-47 2,4-DICHLORO-5-FLUOROANILINE N1-(5-CHLORO-4-FLUORO-2-NITROPHENYL)-2,2,2-TRIFLUOROACETAMIDE 2-Fluoro-5-Chloroaniline /5-Chloro-2-Fluoroaniline / 2-Chloro-3-fluoroaniline 98%,2-CHLORO-3-FLUOROANILINE,2-Chloro-3-fluoroaniline98% 2-[[(4-CHLORO-3-FLUOROPHENYL)AMINO]METHYL]PHENOL
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