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| | Talampicillin hydrochloride Basic information |
| Product Name: | Talampicillin hydrochloride | | Synonyms: | 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 6-[[(2R)-aminophenylacetyl]amino]-3,3-dimethyl-7-oxo-, 1,3-dihydro-3-oxo-1-isobenzofuranyl ester, monohydrochloride, (2S,5R,6R)- (9CI);Ampicillin phthalidyl ester hydrochloride;D-Talampicillin hydrochloride;PC 183;Talat;Talpen;Yamacillin;Ampicillinphthalidyl hydrochloride | | CAS: | 39878-70-1 | | MF: | C24H23N3O6S.ClH | | MW: | 517.988 | | EINECS: | | | Product Categories: | | | Mol File: | 39878-70-1.mol |  |
| | Talampicillin hydrochloride Chemical Properties |
| Melting point | 154-157° (dec) | | form | neat |
| | Talampicillin hydrochloride Usage And Synthesis |
| Originator | Talpen,Beecham,US,1975 | | Manufacturing Process | A fine suspension of 25.18 grams (0.05 mol) of potassium salt of enamine
protected ampicillin and 10.65 grams (0.05 mol) 3-bromophthalide were
reacted in a 1:2 mixture of acetone/ethyl acetate (1,500 ml) for 24 hours.
After filtration the organic layer was washed twice with 250 ml portions of 1 N
sodium bicarbonate and brine, dried over anhydrous magnesium sulfate and
concentrated in vacuo. Addition of ether crystallized the phthalide enamine
protected α-aminophenylacetamido penicillanate in 85% yield. | | Therapeutic Function | Antibacterial |
| | Talampicillin hydrochloride Preparation Products And Raw materials |
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