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| | 4-Fluorobenzoic acid Chemical Properties |
| Melting point | 182-184 °C (lit.) | | Boiling point | 117 °C | | density | 1.479 | | storage temp. | Sealed in dry,Room Temperature | | solubility | alcohol: soluble | | pka | 4.15(at 25℃) | | form | Crystalline Powder | | color | White to slightly yellow | | Water Solubility | Soluble in alcohol, hot water, methanol, and ether. Very slightly soluble in cold water. | | Merck | 14,4171 | | BRN | 1906922 | | InChIKey | BBYDXOIZLAWGSL-UHFFFAOYSA-N | | CAS DataBase Reference | 456-22-4(CAS DataBase Reference) | | NIST Chemistry Reference | Benzoic acid, 4-fluoro-(456-22-4) | | EPA Substance Registry System | Benzoic acid, 4-fluoro- (456-22-4) |
| | 4-Fluorobenzoic acid Usage And Synthesis |
| Description | 4-Fluorobenzoic acid is used as an intermediate in organic synthesis. For instance, it is used to synthesize N-cuccinimidyl 4-[18F]-fluorobenzoate, which is used for the 18F labeling of antibodies. It has been used in high resolution charge density study.
| | Reference | AG. Vaidyanathan, M. R. Zalutsky, Improved Synthesis of N-Succinimidyl 4-[18F]Fluorobenzoate and Its Application to the Labeling of a Monoclonal Antibody Fragment, Bioconjuate Chemistry, 1994, vol. 5, pp. 352-356
| | Chemical Properties | white to light yellow crystal powder | | Uses | 4-Fluorobenzoic acid has been used in high resolution charge density study. | | Definition | ChEBI: A fluorobenzoic acid carrying a fluoro substituent at position 4. | | Purification Methods | Crystallise the acid from 50% aqueous EtOH, then purify it by zone melting or vacuum sublimation at 130-140o. [Beilstein 9 H 333, 9 III 1327, 9 IV 953.] |
| | 4-Fluorobenzoic acid Preparation Products And Raw materials |
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