|
| | CILAZAPRIL Basic information |
| Product Name: | CILAZAPRIL | | Synonyms: | Initiss;Justor;Vascase;9[[1-ETHOXYCARBONYL-3-PHENYLPROPYL]AMINO]OCTAHYDRO-10-OXO-6HPYRIDAZINO[1,2-A][1,2]DIAZEPINE-1-CARBOXYLIC ACID;CILAZAPRIL EPC(;CILAZAPRIL EPC(CRM STANDARD);CILAZAPRIL IMPURITY A1,1-DIMETHYLETHYL(1S,9S)-9-[[(S)-1-ETHOXYCARBONYL-3-PHENYLPROPYL]AMINO]-10-OXO-OCTAHYDRO-6H-PYRIDAZINO[1,2A][1,2]DIAZEPINE-1-CABOXYLATE EPC;[1S-[1α，9α(R^<*>^)]]-9-[[1-(Ethoxycarbonyl)-3-phenylpropyl]amino]octahydro-10-oxo-6H-pyridazino[1，2-α][1，2]diazepine-1-carboxylic acid monohydrate | | CAS: | 92077-78-6 | | MF: | C22H33N3O6 | | MW: | 435.51 | | EINECS: | 200-258-5 | | Product Categories: | Inhibitors | | Mol File: | 92077-78-6.mol |  |
| | CILAZAPRIL Chemical Properties |
| Melting point | 98° (dec) | | alpha | D20 -62.51° (c = 1% in ethanol) | | storage temp. | Store at -20°C | | solubility | Slightly soluble in water, freely soluble in methanol and in methylene chloride. | | form | neat | | pka | pKa1 3.3; pKa2 6.4(at 25℃) |
| | CILAZAPRIL Usage And Synthesis |
| Description | Cilazapril is a new ACE inhibitor useful in the management of mild to moderate
hypertension. Orally administered cilazapril is a prodrug which is de-esterified to its
active diacid metabolite cilazprilat. Compared with enalapril and captopril, cilazapril is
more potent and longer lasting. | | Chemical Properties | White or almost white, crystalline powder. | | Originator | Hoffmann-LaRoche (Switzerland) | | Uses | Antihypertensive. | | Definition | ChEBI: Cilazapril monohydrate is a hydrate that is the monohydrate of cilazapril. It is used for the treatment of hypertension and heart failure. It has a role as an antihypertensive agent, an EC 3.4.15.1 (peptidyl-dipeptidase A) inhibitor and a prodrug. It contains a cilazapril. | | Brand name | Inhibace (Hoffmann-LaRoche). |
| | CILAZAPRIL Preparation Products And Raw materials |
|
