1-(2,6-Dichlorophenyl)indolin-2-one

1-(2,6-Dichlorophenyl)indolin-2-one Basic information
Product Name:1-(2,6-Dichlorophenyl)indolin-2-one
Synonyms:Diclofenac PotassiumⅠ:1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one;Diclofenac Sodium ImpurityⅠ: 1-(2,6-Dichlorophenyl)-1,3-dihydro-2H-indol-2-one;Indolinone (Diclofenac Amide, Diclofenac Lactam);DICLOFENAC RELATED COMPOUND A (50 MG) (N-(2,6-DICHLOROPHENYL)INDOLIN-2-ONE);1-(2,6-Dichlorophenyl)-2,3-dihydro-1H-indole-2-one;Diclofenac Amide;6-Dichlorophenyl)-2-indolinone;N-(2,6-Dichlorophenyl)-Indolin-(2)-One
CAS:15362-40-0
MF:C14H9Cl2NO
MW:278.13
EINECS:239-399-3
Product Categories:Aromatics, Heterocycles, Impurities, Pharmaceuticals, Intermediates & Fine Chemicals;Aromatics;Heterocycles;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:15362-40-0.mol
1-(2,6-Dichlorophenyl)indolin-2-one Structure
1-(2,6-Dichlorophenyl)indolin-2-one Chemical Properties
Melting point 115-119°C
Boiling point 488.6±45.0 °C(Predicted)
density 1.432±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,2-8°C
solubility Chloroform (Slightly), Methanol (Slightly)
form neat
pka-4.85±0.20(Predicted)
color Off-White to Light Brown
BRN 1538309
Stability:Stability
CAS DataBase Reference15362-40-0(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 3
RTECS NM3259200
HS Code 29337900
Toxicitymouse,LD50,unreported,1200mg/kg (1200mg/kg),Pharmaceutical Chemistry Journal Vol. 21, Pg. 275, 1987.
MSDS Information
1-(2,6-Dichlorophenyl)indolin-2-one Usage And Synthesis
Chemical PropertiesOff-White to Light Brown Solid
Uses1-(2,6-Dichlorophenyl)indolin-2-one is a potential prodrug of Diclofenac and possible impurity during its commercial synthesis. It is Aceclofenac EP Impurity I and Diclofenac Impurity A.
1-(2,6-Dichlorophenyl)indolin-2-one Preparation Products And Raw materials
Raw materialsDICLOFENAC METHYL ESTER-->2-(2,6-Dichloroanilino) benzaldehyde-->1-(2,6-Dichlorophenyl)indole-2,3-dione-->Diclofenac sodium-->Methanol
Preparation ProductsOxindole
2-(2-Bromo-6-chlorophenyl)amino)-phenylacetic acid sodium salt 95% Diclofenac Impurity 16 (2-(2,6-DICHLOROANILINO)PHENYL) METHANOL Diclofenac Impurity 7 Diclofenac sodium 2-[((2',6'-DICHLORO-4'-HYDROXY)PHENYL)AMINO]BENZENEACETIC ACID 2,6-DICHLORODIPHENYLAMINE ACECLOFENAC, IMP. I (EP):1-(2,6-DICHLOROPHENYL)INDOLIN-2-ONE MM(CRM STANDARD) Indometacin 1-(2,6-Dichlorophenyl)indolin-2-one Dichloromethylphenylsilane Phenylphosphonic dichloride Fentin hydroxide Oxindole cis-Octahydro-isoindole 1-(2,6-Dichlorophenyl)-2-indolinone Indole-3-acetic acid

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