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| | Nomegestrol Basic information |
| Product Name: | Nomegestrol | | Synonyms: | MELEGESTROL ACETATE;17ALPHA-ACETOXY-6ALPHA-METHYL-19-NOR-PREGN-4,6-DIEN-3,20-DIONE;NOMEGESTROL ACETATE;Nomegestrol;Nomegestrel;17-Hydroxy-6-methyl-19-nor-4,6-pregnadiene-3,20-dione;17-Hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione;(8S,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-6,13-dimethyl-1,2,8,9,10,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one | | CAS: | 58691-88-6 | | MF: | C21H28O3 | | MW: | 328.45 | | EINECS: | 200-258-5 | | Product Categories: | Intermediates & Fine Chemicals;Pharmaceuticals;Steroids;Steroid and Hormone | | Mol File: | 58691-88-6.mol |  |
| | Nomegestrol Chemical Properties |
| Boiling point | 502.6±50.0 °C(Predicted) | | density | 1.17±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | Chloroform: soluble,DMSO: slightly soluble,Methanol: slightly soluble | | form | A solid | | pka | 12.99±0.60(Predicted) |
| | Nomegestrol Usage And Synthesis |
| Description | Nomegestrol acetate is the 19-nor derivative of megestrol acetate, useful in the treatment of gynecological conditions associated with luteal deficiency. | | Description | Nomegestrol is a derivative of 19-norprogesterone. It increases nuclear levels of the progesterone receptor in rat uterus when administered at a dose of 1 mg/animal. | | Originator | Theramex (Monaco) | | Uses | A progestogen, derivatives of which are used in contraceptives and hormone therapies. | | Uses | Progetin used in implantable hormone replacement therapies. | | Definition | ChEBI: Nomegestrol is a corticosteroid hormone. | | Brand name | LUTENYL | | General Description | Nomegestrol acetate, 17-hydroxy-6-methyl-19-norpregna-4,6-diene-3,20-dione acetate,is being investigated as the progestin component of anew oral contraceptive, in combination with the estrogenestradiol. This new combination, NOMAC/E2, is in phaseIII trials and would be the first oral contraceptive to utilizeestradiol itself as the estrogenic component. Structurally,NOMAC is considered a nor-progesterone derivative thatlacks the C19 methyl group in megestrol acetate. |
| | Nomegestrol Preparation Products And Raw materials |
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