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Naphazoline nitrate

Naphazoline nitrate Basic information
Product Name:Naphazoline nitrate
Synonyms:NAPHAZOLINE NITRATE;NAPHAZOLINE NITRATE SALT;NAPHAZOLINI NITRAS;LABOTEST-BB LT00134653;2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM NITRATE;2-(1-NAPHTHYLMETHYL)IMIDAZOLINE NITRATE;2-[1-NAPHTHYLMETHYL]IMIDAZOLINE NITRATE SALT;2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE NITRATE
CAS:5144-52-5
MF:C14H15N3O3
MW:273.29
EINECS:225-915-4
Product Categories:API
Mol File:5144-52-5.mol
Naphazoline nitrate Structure
Naphazoline nitrate Chemical Properties
Melting point 167-170 °C
solubility Sparingly soluble in water, soluble in ethanol (96 per cent).
form neat
Sensitive Hygroscopic
BRN 3779329
InChIKeyZAHXYMFVNNUHCP-UHFFFAOYSA-N
CAS DataBase Reference5144-52-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 22
Safety Statements 22-36/37-60-36
RIDADR 3249
WGK Germany 3
RTECS NJ4376000
F 3-10
HazardClass 6.1(b)
PackingGroup III
HS Code 29332900
MSDS Information
ProviderLanguage
SigmaAldrich English
ALFA English
Naphazoline nitrate Usage And Synthesis
Chemical PropertiesWhite or almost white, crystalline powder.
Usesantihistamine
IndicationsNaphazoline hydrochloride and naphazoline nitrate are white or almost white crystalline powders soluble 1 in 6 and 1 in 36 water, respectively. These are potent sympathomimetic vasoconstrictors with a direct alpha-adrenergic receptor stimulatory action, and may be used as topical decongestants in 0.05% or 0.1% eyedrops. Frequent application of these solutions will produce a reactive hyperaemia. Instillation should not be repeated in less than 4-6 hours to avoid this rebound congestion.
Naphazoline eyedrops cause slight mydriasis and are contra-indicated in patients with actual or suspected closed-angle glaucoma.
Although not administered systemically, topical application of naphazoline has resulted in systemic absorption, and it is readily absorbed from the gastro-intestinal tract (Martindale, 1977).

DefinitionChEBI: Naphazoline nitrate is a member of naphthalenes.
Naphazoline nitrate Preparation Products And Raw materials
Raw materials1-Naphthaleneacetic acid
Preparation ProductsNeomycin
Econazole nitrate 2-METHYL-2-IMIDAZOLINE Oxymetazoline Propionamidine hydrochloride Naphazoline hydrochloride Miconazole Nitrate Naphazoline Imidazoline inhibitor Ammonium nitrate Naphazoline nitrate 2-ETHYLIMIDAZOLINE Methylamine nitrate 1-ETHYLNAPHTHALENE 2-NAPHTHALEN-1-YL-ACETAMIDINE Imidazolidine Oxymetazoline hydrochloride (4-ISOPROPOXY-PHENYL)-HYDRAZINE HYDROCHLORIDE NITRATE
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