m-Toluidine

m-Toluidine Basic information
Product Name:m-Toluidine
Synonyms:M-Toluidine, 99% 5ML;M-TOLUIDINE FOR SYNTHESIS 100 ML;M-TOLUIDINE FOR SYNTHESIS 1 L;Between toluidine;M-Toluidine 0;AKOS BBS-00003559;3-METHYLBENZENAMINE;3-AMINO-1-METHYLBENZENE
CAS:108-44-1
MF:C7H9N
MW:107.15
EINECS:203-583-1
Product Categories:amine;Intermediates of Dyes and Pigments;Azo dye;Organics;3-Amino-1-Methylbenzene
Mol File:108-44-1.mol
m-Toluidine Structure
m-Toluidine Chemical Properties
Melting point -30 °C
Boiling point 203-204 °C(lit.)
density 0.999 g/mL at 25 °C(lit.)
vapor pressure 0.3 hPa (20 °C)
refractive index n20/D 1.567(lit.)
Fp 186 °F
storage temp. Store below +30°C.
solubility 0.2 g/100 mL (20°C)
pka4.73(at 25℃)
form Crystalline Solid or Liquid
color White
PH7 (H2O, 20℃)
Odoraromatic aniline-like odor
Water Solubility 0.2 g/100 mL (20 ºC)
Merck 14,9536
BRN 635944
Exposure limitsTLV-TWA skin 2-ppm (~9 mg/m3) (ACGIH).
InChIKeyJJYPMNFTHPTTDI-UHFFFAOYSA-N
LogP1.4 at 25℃
CAS DataBase Reference108-44-1(CAS DataBase Reference)
NIST Chemistry ReferenceBenzenamine, 3-methyl-(108-44-1)
EPA Substance Registry Systemm-Toluidine (108-44-1)
Safety Information
Hazard Codes T,N
Risk Statements 45-23/24/25-33-50
Safety Statements 53-28-36/37-45-61-28A
RIDADR UN 1708 6.1/PG 2
WGK Germany 2
RTECS XU2800000
8-23
Autoignition Temperature>500 °C
Hazard Note Toxic
TSCA Yes
HazardClass 6.1
PackingGroup II
HS Code 29171990
HS Code 29214300
Hazardous Substances Data108-44-1(Hazardous Substances Data)
MSDS Information
ProviderLanguage
3-Aminotoluene English
SigmaAldrich English
ACROS English
ALFA English
m-Toluidine Usage And Synthesis
Chemical PropertiesColorless liquid. Slightly soluble in water; soluble in alcohol or ether. Combustible.
Usesm-Toluidine is an intermediate in the manu facture of dyes and other chemicals.
UsesDyes, manufacture of organic chemicals.
Usesm-Toluidine is used in the manufacture of organic chemicals. It is also used in manufacture of various dyes and pigments, photo chemicals, pharmaceutical intermediates.antioxidants, curing agent, accelerator for polymer and rubber industry.
Synthesis Reference(s)Synthetic Communications, 11, p. 925, 1981 DOI: 10.1080/00397918108065749
General DescriptionA clear colorless liquid. Flash point below 200°F. Vapors heavier than air. Toxic by inhalation, ingestion, and skin absorption in high concentrations or under prolonged exposures. Used in the manufacture of organic chemicals. Density about 8 lb / gal.
Reactivity Profilem-Toluidine neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. Can react vigorously with oxidizing reagents. Emits toxic fumes of oxides of nitrogen when heated to decomposition [Lewis, 3rd ed., 1993, p. 1253].
Health HazardAbsorption of toxic quantities by any route causes cyanosis (blue discoloroation of lips, nails, skin); nausea, vomiting, and coma may follow. Repeated inhalation of low concentrations may cause pallor, low-grade secondary anemia, fatigability, and loss of appetite. Contact with eyes causes irritation.
Health HazardThe toxicity of m-toluidine is similar to thatof o-toluidine. The exposure routes are ingestion, inhalation, and absorption through skin.The toxic effects are methemoglobinemia,anemia, and hematuria. It metabolizes to 2-amino-4-methylphenol, the major componentexcreted in urine. Inhalation of 40-ppm concentration for an hour produced severe poi soning in humans. The oral LD50 value inmice is 740 mg/kg, which is in a range com parable to its o- and p-isomers.
The pure liquid is a mild to moderate skinirritant. Its irritating effect on the eyes ofrabbits was strong.
m-Toluidine did not induce any carcino genicity in test subjects. This finding is incontrast to its ortho-isomer. Nor did it produce any mutagenic activity.

Fire HazardSpecial Hazards of Combustion Products: Toxic oxides of nitrogen and flammable vapors may form in fire.
Flammability and ExplosibilityNonflammable
Safety ProfilePoison by ingestion and intraperitoneal routes, A skin and eye irritant. Flammable when exposed to heat or flame. Can react vigorously on contact with oxidizing materials. To fight fire, use foam, CO2, dry chemical. When heated to decomposition it emits hghly toxic fumes of NOx. See also ANILINE and o-TOLUIDINE.
CarcinogenicityIn an 18-month carcinogenicity diet evaluation in maleCD rats (8000 ppm for 3 months, and then 4000 ppm for additional 15 months; or 16,000 ppm for 3 months, and then 8000 for additional 15 months), and male and female CD-1 mice (16,000 ppm for 5 months, and then 4000 ppm in males and 8000 ppm in females for additional 13 months; or 32,000 ppm in both sexes for 5 months, and then 8000 ppm in males and 16,000 ppm in females for additional 13 months), there was no evidence of a significant increase of incidence of any kind of tumor in the rats, and only a significant increase in liver tumors in male mice.
Purification MethodsIt can be purified as for aniline. Twice-distilled, m-toluidine is converted to the hydrochloride using a slight excess of HCl, and the salt is fractionally crystallised from 25% EtOH (five times), and from distilled water (twice), rejecting, in each case, the first material that crystallised out. The amine is regenerated and distilled as for o-toluidine. The benzoyl derivative has m 125o (from EtOH). [Berliner & May J Am Chem Soc 49 1007 1927, Beilstein 12 H 853, 12 I 397, 12 II 463, 12 III 1949, 12 IV 1813.]
A,A,A-TRIPHENYL-P-TOLUIDINE,A,A,A-TRIPHENYL-P-TOLUIDINE N,N-DIETHYL-O-TOLUIDINE N-(2-CYANOETHYL)-N-(2-HYDROXYETHYL)-M-TOLUIDINE 2--5-(MTA) N-2-HYDROXYETHYL-P-TOLUIDINE Sodium 3-(N-ethyl-3-methylanilino)propanesulfonate N-METHYL-P-TOLUIDINE 3,3',5,5'-Tetramethylbenzidine dihydrochloride EC 2.6.1.2 3-Methoxy-2-methylaniline toluidine ALPHA,ALPHA,ALPHA-TRIFLUORO-6-(METHYLTHIO)-M-TOLUIDINE,ALPHA,ALPHA,ALPHA-TRIFLUORO-6-(METHYLTHIO)-M-TOLUIDINE N-METHYL-N-(2-CYANOETHYL)-P-TOLUIDINE N-(2-CYANOETHYL)-N-BUTYL-M-TOLUIDINE 3-(Methylamino)toluene 4-Methylaniline hydrochloride 6-CHLORO-O-TOLUIDINE-4-SULFONIC ACID,6-CHLORO-O-TOLUIDINE-4-SULFONIC ACID N-Ethyl-3-methylaniline

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