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| | Sitagliptin N-Boc IMpurity Basic information |
| Product Name: | Sitagliptin N-Boc IMpurity | | Synonyms: | Sitagliptin N-Boc IMpurity;Boc-Sitagliptin;N-Boc-Sitagliptin;(R)-tert-Butyl (4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-yl)carbamate;tert-Butyl N-[(2R)-4-oxo-4-[3-(trifluoromethyl)-6,8-dihydro-5H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-1-(2,4,5-trifluorophenyl)butan-2-yl]carbamate;Sitagliptin N-Boc;tert-butyl (R)-(4-oxo-4-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4] triazolo[4,3-a]pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan- 2-yl)carbamate;Sitagliptin Impurity 56 | | CAS: | 486460-23-5 | | MF: | C21H23F6N5O3 | | MW: | 507.43 | | EINECS: | 1312995-182-4 | | Product Categories: | | | Mol File: | 486460-23-5.mol |  |
| | Sitagliptin N-Boc IMpurity Chemical Properties |
| Melting point | 188-191 °C(Solv: toluene (108-88-3)) | | density | 1.46±0.1 g/cm3(Predicted) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly, Heated), DMSO (Slightly), Ethyl Acetate (Slightly) | | pka | 11.60±0.46(Predicted) | | form | Solid | | color | White |
| | Sitagliptin N-Boc IMpurity Usage And Synthesis |
| Uses | N-Boc-Sitagliptin is the N-Boc protected derivative of Sitagliptin (S490990), a dipeptidyl peptidase-4 inhibitor that is used for glycemic control for patients with type 2 diabetes. |
| | Sitagliptin N-Boc IMpurity Preparation Products And Raw materials |
| Raw materials | 486460-25-7-->3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine-->Benzenebutanoicacid,b-[[(1,1-diMethylethoxy)carbonyl]aMino]-2,4,5-trifluoro-,Methylester,(bR)--->BOC-(R)-3-AMINO-4-(2,4,5-TRIFLUORO-PHENYL)-BUTYRIC ACID-->3-(Trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride-->BOC-D-2,4,5-TRIFLUOROPHE-->3-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine-->2,4,5-Trifluorobenzyl bromide-->1-Bromo-2,4,5-trifluorobenzene-->tert-Butanol-->Di-tert-butyl dicarbonate |
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