ChemicalBook Product Catalog Organic Chemistry Organic fluorine compound Fluoro isatin series 5-Fluoroisatin

5-Fluoroisatin

5-Fluoroisatin Basic information
Product Name:5-Fluoroisatin
Synonyms:BUTTPARK 24\07-36;AKOS BBS-00006537;5-FLUOROINDOLINE-2,3-DIONE;5-FLUOROISATIN;5-FLUOROISATINE;5-FLUOROINDOLE-2,3-DIONE;5-FLUORO-1H-INDOLE-2,3-DIONE;5-Fluoroisatin,98%
CAS:443-69-6
MF:C8H4FNO2
MW:165.12
EINECS:628-890-1
Product Categories:Fluorinated heterocyclic series;Heterocyclic Building Blocks;blocks;IndolesOxindoles;Indole/indoline/oxindole;Indole and Indoline;Isatin series;Indane/Indanone and Derivatives;Sunitinib;Heterocyclic Compounds;Indoles;Simple Indoles;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Boronic Acid;Building Blocks
Mol File:443-69-6.mol
5-Fluoroisatin Structure
5-Fluoroisatin Chemical Properties
Melting point 224-227 °C (lit.)
density 1.477±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility Chloroform, DMSO, Methanol
pka8.51±0.20(Predicted)
form Powder
color Red
BRN 131241
InChIKeyGKODDAXOSGGARJ-UHFFFAOYSA-N
CAS DataBase Reference443-69-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-37/39-36
WGK Germany 3
HazardClass IRRITANT
HS Code 29337900
MSDS Information
ProviderLanguage
ACROS English
SigmaAldrich English
ALFA English
5-Fluoroisatin Usage And Synthesis
Chemical Propertiesred Crystalline Powder
UsesIt showed antibacterial and antifungal activities.
UsesReactant for preparation of:
  • Spiro[indole-thiazolidinones] as biologically relevan synthesis scaffolds
  • Potential antimycobacterial agents
  • Inhibitors of c-Met kinase
  • Inhibitors of TAK1 kinase
  • Herpes simplex virus inhibitors
  • IKKβ inhibitors
  • Inhibitors of vitiligo disease
  • Potential drug candidates with anti-HIV activity and anti-tubercular activity
DefinitionChEBI: 5-Fluoroisatin is a member of indoles. It has a role as an anticoronaviral agent.
General Description5-Fluoroisatin has been reported as the precursor of the Sunitinib (Sutent) drug. 5-Fluoroisatin has been approved by the Food and Drugs Administration (FDA) in 2006 for the treatment of renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST).
5-Fluoroisatin Preparation Products And Raw materials
Preparation ProductsFlumazenil-->5-FLUORO-1-METHYL-1H-INDOLE-2,3-DIONE-->5-Fluoro-3-indazolecarboxylic acid-->5-((Z)-(5-Fluoro-2-oxoindolin-3-ylidene)methyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic acid-->5-Fluoro-7-nitroindole-2,3-dione-->AKOS BBS-00001013
Dehydroepiandrosterone Indometacin 5-fluoro-1-(2-hydroxyethyl)-2,3-dihydro-1H-indole-2,3-dione Isatin 5-Fluoro-2-oxindole 5-Fluoro-7-Methyl Isatin 5-Fluoroisatin cis-Octahydroisoindole BUTTPARK 89\07-57 AKOS BBS-00006013 6-Chloro-5-fluoroindole 5-Fluoroindole Isophorone 1-ACETYL-5-FLUORO-1H-INDOLE-2,3-DIONE Indole-3-acetic acid Isatoic Anhydride Indirubin AKOS BC-1689
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