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Piretanide

Piretanide Basic information
Product Name:Piretanide
Synonyms:PIRETANIDE;4-phenoxy-3-pyrrolidin-1-yl-5-sulfamoyl-benzoic acid;4-Phenoxy-3-(pyrrolidinyl)-5-sulfamoylbenzoic acid;4-Phenoxy-3-(1-pyrrolidinyl)-5-sulfamoylbenzoic acid;HOE 118;hoe-118;S 734118;S-73-4118
CAS:55837-27-9
MF:C17H18N2O5S
MW:362.4
EINECS:259-852-9
Product Categories:Pharmaceuticals;Sulfur & Selenium Compounds;Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals
Mol File:55837-27-9.mol
Piretanide Structure
Piretanide Chemical Properties
Melting point 225-227°
Boiling point 253°C (rough estimate)
density 1.3049 (rough estimate)
refractive index 1.6510 (estimate)
storage temp. 2-8°C
solubility Very slightly soluble in water, sparingly soluble in anhydrous ethanol. It shows polymorphism (5.9).
pka10.22±0.60(Predicted)
form neat
color Pale-yellow platelets from MeOH (aq)
CAS DataBase Reference55837-27-9(CAS DataBase Reference)
Safety Information
ToxicityLD50 in rats, mice (mg/kg): 5601, 3672 orally (Merkel)
MSDS Information
Piretanide Usage And Synthesis
Chemical PropertiesPale Yellow Solid
OriginatorArelix ,Hoechst, Italy ,1980
UsesHigh-ceiling loop diuretic; structurally related to Bumetanide (B689550). Diuretic.
DefinitionChEBI: Piretanide is an aromatic ether.
Brand nameArlix (Hoechst-Roussel).
Therapeutic FunctionDiuretic
Safety ProfilePoison by intravenous route. Moderately toxic by ingestion, intraperitoneal, and subcutaneous routes. An experimental teratogen. Experimental reproductive effects. Used as a diuretic agent. When heated to decomposition it emits very toxic fumes of SOx an
Piretanide Preparation Products And Raw materials
Raw materialsSodium hydroxide-->Sodium borohydride
(3-PYRROLIDIN-1-YLPHENYL)METHANOL 3-(Dimethylamino)benzoic acid Povidone iodine 3-PYRROLIDIN-1-YLBENZALDEHYDE N-Methyl-2-pyrrolidone AQUANTRAAL N-Vinyl-2-pyrrolidone Piretanide 4-Dimethylaminobenzoic acid Polyvinylpyrrolidone 4-Aminobenzoic acid 3-PYRROLIDIN-1-YL-BENZOIC ACID N-Methyl pyrrole METHYL-2-PYRROLIDONE 4-PHENOXYBENZOIC ACID 3-Amino-4-methoxybenzoic acid Bumetanide 2-(1-PYRROLIDINO)PHENOL
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