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| | Methoxypolyethylene glycol amine Basic information |
| Product Name: | Methoxypolyethylene glycol amine | | Synonyms: | AMINOPOLYETHYLENE GLYCOL 10,000 MONOMETHYL ETHER;AMINOPOLYETHYLENE GLYCOL 10'000 MONOMETHYL ETHER;AMINOPOLYETHYLENE GLYCOL 20,000 MONOMETHYL ETHER;Poly(ethylene glycol) α-2-aMinoethyl, ω-Methoxy;MPEGn-NH2 2K, 5K, 10K, 20K;MPEG-AMine, average M.W. 4,000;MPEG-AMine, average M.W. 10,000;MPEG-AMine, average M.W. 1,000 | | CAS: | 80506-64-5 | | MF: | C5H13NO2 | | MW: | 119.16222 | | EINECS: | | | Product Categories: | Polydispersed PEG;PEG;Amine;Materials Science;Monofunctional PEGs;Poly(ethylene glycol) and Poly(ethylene oxide);Polymer Science;Polymers | | Mol File: | 80506-64-5.mol |  |
| | Methoxypolyethylene glycol amine Chemical Properties |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | F | 2-9 | | TSCA | Yes | | HS Code | 39072090 |
| | Methoxypolyethylene glycol amine Usage And Synthesis |
| Description | m-PEG15-amine is a PEG linker containing an amino group and 15 PEG units. It is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The hydrophilic PEG spacer increases solubility in aqueous media. | | Uses | MPEG-NH2 is a reactant in synthesis of pH-sensitive polymeric micelles for intracellular drug delivery. | | Uses | PEG functionalized with amine for ligation and coupling reactions. | | Uses | Methoxypolyethylene glycol amine is generally used for the chemical modification of biologically active compounds and therapeutic agents. It has been used to increase the aqueous solubility of long-wavelength voltage-sensitive dyes and to prepare the PEG-coated fluorescent beads in studying large-scale rotational cytoplasmic flow. | | Application | Methoxypolyethylene glycol amine is used in the reduction of immunogenicity and increasing serum half life.Methoxypolyethylene glycol amine can:
Form dendritic micelles to enhance the solubility of hydrophobic compounds.
Conjugate with an anticancer drug methotrexate (MTX) to form MTX-PEG with potential application as drug carriers.
Couple with polyethylenimine (PEI) to form graft copolymers which can be used as nonviral gene vectors.
PEG functionalized with amine for ligation and coupling reactions. |
| | Methoxypolyethylene glycol amine Preparation Products And Raw materials |
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