ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Pyridine derivatives 2-Methoxypyridine

2-Methoxypyridine

2-Methoxypyridine Basic information
Synthesis
Product Name:2-Methoxypyridine
Synonyms:METHYL 2-PYRIDYL ETHER;2-METHOXYPYRIDINE;2-Methoxypyridine98%;2-Methoxypyridine 99%;Methyl pyridin-2-yl ether;2-Methoxyl pyridine;2-Pyridol methyl ether;2-METHOXY PYRIDINE FEMA NO.--------
CAS:1628-89-3
MF:C6H7NO
MW:109.13
EINECS:216-623-8
Product Categories:Pyridines, Pyrimidines, Purines and Pteredines;Pyridines derivates;Pyridines;Anisoles, Alkyloxy Compounds & Phenylacetates;Miscellaneous Compounds;C6;Pyridine;Heterocyclic Building Blocks;bc0001
Mol File:1628-89-3.mol
2-Methoxypyridine Structure
2-Methoxypyridine Chemical Properties
Boiling point 142 °C (lit.)
density 1.038 g/mL at 25 °C (lit.)
refractive index n20/D 1.503(lit.)
FEMA 4639 | 2-METHOXYPYRIDINE
Fp 90 °F
storage temp. Inert atmosphere,Room Temperature
form Liquid
pka3.28(at 20℃)
color Clear colorless to slightly yellow
Odorat 0.10?%?in?propylene glycol. green fermented tea
Water Solubility INSOLUBLE
JECFA Number2156
BRN 108189
InChIKeyIWTFOFMTUOBLHG-UHFFFAOYSA-N
LogP1.32
CAS DataBase Reference1628-89-3(CAS DataBase Reference)
NIST Chemistry ReferencePyridine, 2-methoxy-(1628-89-3)
Safety Information
Hazard Codes Xi,F
Risk Statements 10-36/37/38
Safety Statements 26-36-16
RIDADR UN 1993 3/PG 3
WGK Germany 3
HazardClass 3
PackingGroup III
HS Code 29339900
MSDS Information
ProviderLanguage
2-Methoxypyridine English
SigmaAldrich English
ACROS English
ALFA English
2-Methoxypyridine Usage And Synthesis
SynthesisCsSO4F may be used to fluorinate pyridine directly, but the reaction is very sensitive to the solvents employed. When solvents such as pentane and diethyl ether were used, 2-fluoropyridine was the major product, but use of nucleophilic solvents, such as methanol gave 2-methoxypyridine.
Synthesis of 2-Methoxypyridine
Chemical PropertiesClear colorless to slightly yellow liquid
Uses2-Methoxypyridine can be used as an intermediate to synthesize 2-methoxy-3-pyridinesulfonyl chloride which is patented as a reactant used to prepare erythromycin macrolide antibiotics as antibacterial and antiprotozoal agents. It can also be used to prepare bicyclic iminopyrimidinones as Beta Amyloid Cleaving Enzyme-1 (BACE1) inhibitors.
2-Methoxypyridine Preparation Products And Raw materials
Preparation Products6-Methoxynicotinaldehyde-->2-METHOXY-3-PYRIDINECARBOXALDEHYDE-->4-Amino-2-methoxypyridine-->7-CHLORO-10-(4-HYDROXYANILINO)-2-METHOXY BENZO(B)-1,5-NAPHTHY RIDINE-->2-Methoxypyridine-3-boronic acid-->(2-OXOPYRIDIN-1(2H)-YL)ACETIC ACID-->2-Pyridinol-1-oxide-->2-METHOXY-3-METHYLPYRIDINE-->5-Bromo-2-methoxypyridine-->2-ACETYL-6-METHOXYPYRIDINE 97-->3-Iodo-2-methoxypyridine-->2-METHOXY-3,5-DIBROMO-PYRIDINE-->2-METHOXYPIPERIDINE-->1-(prop-2-yn-1-yl)-1,2-dihydropyridin-2-one-->Pyridine, 3-(4-fluorophenyl)-2-methoxy-
6'-BUTOXY-2,6-DIAMINO-3,3'-AZODIPYRIDINE, 99 2-(octadecyloxy)pyridine 2-(HEXADECYLOXY)PYRIDINE 2-PHENOXYNICOTINIC ACID 2-N-BUTOXYPYRIDINE 2-Methoxypyridine 2-Methoxy-3-nitropyridine 2-(DODECYLOXY)PYRIDINE 3-AMINO-2,6-DIMETHOXYPYRIDINE MONOHYDROCHLORIDE 2-Ethoxypyridine 6-Chloro-2-methoxypyridine 2,6-bis[2-(dimethylamino)ethoxy]pyridine 2,6-Dimethoxypyridine Dibucaine hydrochloride 2-Methoxy-5-nitropyridine 1-AZA-2-N-BUTOXY-6,9-DICHLORO-ACRIDINE 2-CHLORO-6-ETHOXYPYRIDINE 2-ALLYLOXYPYRIDINE
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