Schisandrin

Schisandrin Basic information
Product Name:Schisandrin
Synonyms:Schisandrin,Schizandrin;chisandrin 5,6,7,8-Tetrahydro-6,7-dimethyl-1,2 3,10,11,12-hexamethoxydibenzo[a,c]cycloocten-6-ol;Schizandrin, >=98%;SCHISANDRIN;WUWEIZI ALCOHOL A;SCHISANDRIN (SCHISANDROL A);Schizandrin std.;Schisandrin(Schizandrol A)
CAS:7432-28-2
MF:C24H32O7
MW:432.51
EINECS:
Product Categories:Inhibitors;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;Miscellaneous Natural Products;Natural Plant Extract;chemical reagent;pharmaceutical intermediate
Mol File:7432-28-2.mol
Schisandrin Structure
Schisandrin Chemical Properties
Melting point 128.5°C
Boiling point 466.17°C (rough estimate)
density 1.1480 (rough estimate)
refractive index 1.5800 (estimate)
storage temp. 2-8°C
solubility DMSO: ≥13mg/mL
form powder
pka14.58±0.40(Predicted)
color white to beige
optical activity[α]/D 75 to 95°, c = 1 in methanol
InChIKeyYEFOAORQXAOVJQ-UHFFFAOYSA-N
LogP3.153 (est)
Safety Information
Hazard Codes Xn,N
Risk Statements 22-50/53
Safety Statements 60-61
RIDADR UN 3077 9 / PGIII
WGK Germany 3
HS Code 29093090
MSDS Information
Schisandrin Usage And Synthesis
DescriptionSchizandrin is a dibenzocyclooctadiene lignan and a major component of S. chinensis and has diverse biological activities. It induces cell cycle arrest at the G0/G1 phase and inhibits growth of T47D and MDA-MB-231 breast cancer cells when used at a concentration of 100 μM. Schizandrin (10 and 100 μM) prevents glutamate-induced cytotoxicity, inhibits production of nitric oxide (NO) and reactive oxygen species (ROS), and preserves the mitochondrial membrane potential in isolated rat cortical cells. It reduces apoptosis induced by cisplatin in HK-2 human kidney cells. In vivo, schizandrin (1 and 10 mg/kg, p.o.) reverses scopolamine-induced impairment of spatial memory and the passive avoidance response in rats. It enhances oxotremorine-induced tremors in mice. Schizandrin (10 mg/kg) reduces serum levels of IgE, IgG1, IL-4, and IFN-γ in an ovalbumin-sensitized mouse model of allergy.
UsesSchizandrin may be used in oxidative stress-related cell signaling studies.
ApplicationSchizandrin is a natural compound that belongs to the group of schisandrins. Schizandrins are a class of compounds with biochemical properties and biological activities, such as anti-inflammatory, antioxidant, and anti-cancer effects. This compound has been shown to have pro-apoptotic properties in a model system. It has also demonstrated the ability to inhibit influenza A virus replication in vitro and protect mice against Listeria monocytogenes infection. It can be used as an inhibitor of gsh-px activity in myocardial infarcts.
DefinitionChEBI: Schizandrin is a tannin.
Biochem/physiol ActionsSchizandrin is a natural product with several biological properties involved with antioxidant and anti-inflammatory activities. It reduces the formation of ROS, inhibits the mitochondrial pathway of the apoptotic process and oxidative stress. Schizandrin has been reported to have hepatoprotective, antitumor, antiviral, and antiamnesic effects, and has neuroprotective activity against glutamate induced neurotoxicity.
Schisandrin Preparation Products And Raw materials
SCHISANDRIN, gamma-(Wuweizisu B)(AHP) methyl hydroselenide 4'-METHOXY-2-METHYL-BIPHENYL 3-(3,4,5-TRIMETHOXY-PHENYL)-PROPAN-1-OL Tetrahydro G-SCHISANDRIN 4,4'-Dimethoxybiphenyl SCHISANDROL B (GOMISIN A)(P) SCHISANDRIN SNAP-N-SHOOT 0.1mg/mL(P) 2-(3,4,5-TRIMETHOXYPHENYL)ETHANOL SCHISANDRIN A+B γ-Schisandrin 2,2',4,4'-BIPHENYLTETROL Dimethyl sebacate 3-(3,4-DIMETHOXYPHENYL)-1-PROPANOL SCHISANDRA P.E./ SCHISANDRIN Schizandra Chinesis (9% Schisandrin) Nortropine

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