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| | DIHYDROMETHYSTICIN Basic information |
| Product Name: | DIHYDROMETHYSTICIN | | Synonyms: | 6-(2-(1,3-benzodioxol-5-yl)ethyl)-5,6-dihydro-4-methoxy-2h-pyran-2-on(s);6-dihydro-4-methoxy-6-(3,4-(methylenedioxy)phenethyl)-(s)-2h-pyran-2-on;7,8-dihydromethysticin;dhm;DIHYDROMETHYLSTICIN;7,8-DIHYDROMETHYLSTICIN;5,6-Dihydro-4-methoxy-6-[2-(1,3-benzodioxol-5-yl)ethyl]-2H-pyran-2-one;6-[2-(1,3-Benzodioxol-5-yl)ethyl]-4-methoxy-5,6-dihydro-2H-pyran-2-one | | CAS: | 19902-91-1 | | MF: | C15H16O5 | | MW: | 276.28 | | EINECS: | | | Product Categories: | Coumarins | | Mol File: | 19902-91-1.mol |  |
| | DIHYDROMETHYSTICIN Chemical Properties |
| storage temp. | 2-8°C | | solubility | Chloroform (Slightly), Methanol (Slightly), Pyridine (Slightly) | | density | 1.28±0.1 g/cm3(Predicted) | | form | neat | | Boiling point | 476.1±45.0 °C(Predicted) | | Melting point | 117-118 °C | | color | White to Off-White | | BRN | 91699 | | Stability: | Hygroscopic | | InChIKey | RSIWXFIBHXYNFM-NSHDSACASA-N | | LogP | 1.810 (est) |
| | DIHYDROMETHYSTICIN Usage And Synthesis |
| Description | Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties. Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 μM. Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice. It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg. | | Uses | (6S)-6-[2-(1,3-Benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one, is used in toxicity studies through in vitro analysis. This complex is found in the roots of kava plant. | | Definition | ChEBI: Dihydromethysticin is a member of 2-pyranones and an aromatic ether. |
| | DIHYDROMETHYSTICIN Preparation Products And Raw materials |
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