ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Pyridine derivatives 4-(4-Aminophenoxy)-N-methylpicolinamide

4-(4-Aminophenoxy)-N-methylpicolinamide

4-(4-Aminophenoxy)-N-methylpicolinamide Basic information
Product Name:4-(4-Aminophenoxy)-N-methylpicolinamide
Synonyms:4-(4-aMiNApheNAxy)-N-MethylpicolinaMide;4-(4-aMinophenoxy)-N-MethylpicolinaMide oxalate;N-Methyl-4-(4-aMinophenoxy)pyridine-2-carboxaMide;Sorafenib impurity A;Sorafenib Intermediate;Sorafenib Related Compound 23;Sorafen;Sorafenib Aminophenoxy Impurity
CAS:284462-37-9
MF:C13H13N3O2
MW:243.26
EINECS:608-211-5
Product Categories:Sorafinib;Aromatics Compounds;Aromatics;Bases & Related Reagents;Heterocycles;Nucleotides;Sorafenib tosylate;284462-37-9
Mol File:284462-37-9.mol
4-(4-Aminophenoxy)-N-methylpicolinamide Structure
4-(4-Aminophenoxy)-N-methylpicolinamide Chemical Properties
Melting point 110-112°C
Boiling point 476.8±40.0 °C(Predicted)
density 1.241±0.06 g/cm3(Predicted)
vapor pressure 0.001-0.05Pa at 20-109.84℃
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility DMSO (Slightly), Methanol (Slightly)
pka13.96±0.46(Predicted)
form Notspecified
color White to Light yellow to Light orange
LogP0.9 at 25℃ and pH7
Surface tension71.71mN/m at 883.8mg/L and 20.1℃
Safety Information
HazardClass IRRITANT
HS Code 2933399990
MSDS Information
4-(4-Aminophenoxy)-N-methylpicolinamide Usage And Synthesis
Chemical PropertiesLight-Brown Solid
UsesSorafenib intermediate
4-(4-Aminophenoxy)-N-methylpicolinamide Preparation Products And Raw materials
Preparation ProductsN-Methyl-4-(4-(3-(trifluoroMethyl)benzaMido)phenoxy)picolinaMide Tosylate-->Sorafenib
Sorafenib IMpurity Sorafenib related compound 10 4-Chloro-alpha,alpha,alpha-trifluoro-m-toluidine 1,4-Benzoquinoneimine 1-(4-chloro-3-(trifluoromethyl)phenyl)urea 4-HYDROXYPHENYLFORMAMIDE Trimebutine maleate N-Methyl-4-chloropyridine-2-carboxamide Sorafenib Impurity 35 Sorafenib tosylate Sorafenib tosylate Sorafenib Impurity 43 Vatalanib base N,N-Dimethylformamide 4-(4-Aminophenoxy)-N-methylpicolinamide 4-(4-AMINO-3-FLUOROPHENOXY)-N-METHYLPICOLINAMIDE PYRIDINE-2-CARBOXAMIDE N-Methylformamide
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