Cilastatin

Cilastatin Basic information
Product Name:Cilastatin
Synonyms:Cilistatin Acid;(z)-7-[(2s)-2-amino-3-hydroxy-3-oxopropyl]sulfanyl-2-[[(1s)-2,2-dimethylcyclopropanecarbonyl]amino]hept-2-enoic acid;(r-(r*,s*-(z)))-)carbonyl)amino);mk-791;CILASTATIN;Cilastain;(2Z)-7-[[(2R)-2-amino-2-carboxyethyl]thio]-2-[[[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino]-2-heptenoic Acid;[R-[R^<*>^,S^<*>^(Z)]]-7-[(2-Amino-2-carboxyethyl)thio]-2-[[(2,2-dimethylcyclopropyl)carbonyl]amino]-2-heptenoic acid
CAS:82009-34-5
MF:C16H26N2O5S
MW:358.45
EINECS:279-875-8
Product Categories:Inhibitors;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:82009-34-5.mol
Cilastatin Structure
Cilastatin Chemical Properties
Melting point 156-158°C
Boiling point 655.5±55.0 °C(Predicted)
density 1.275±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly, Sonicated)
form Solid
pka2.09±0.10(Predicted)
color White to Light Brown
CAS DataBase Reference82009-34-5(CAS DataBase Reference)
Safety Information
MSDS Information
Cilastatin Usage And Synthesis
DescriptionCilastatin is an inhibitor of dipeptidase (dehydropeptidase I), a renal dipeptidase. It inhibits human renal dipeptidase (Ki = 0.7 μM), porcine dipeptidase (IC50 = 0.11 μM), and bacterial metallo-β-lactamase CphA from A. hydrophila (IC50 = 178 μM). Cilastatin (200 μg/ml) protects primary porcine renal proximal tubular epithelial cells from nephrotoxicity and apoptosis induced by vancomycin . In a mouse model of systemic infection, cilastatin in combination with imipenem protects mice from S. aureus, E. coli, and P. aeruginosa infection. Cilastatin was designed to inhibit renal metabolism of imipenem and prolong its half-life. Formulations containing cilastatin in combination with imipenem have been used to treat susceptible bacterial infections.
Chemical PropertiesWhite to Light-Yellow Crystalline Powder
Usesspectrum antibiotic
UsesPrevents renal metabolism of penem and carbapenem antibiotics by specific and reversible dehydropeptidase I inhibition. Antibacterial adjunct
UsesCilastatin is used for treating diseases caused by polyresistant Gram-negative microorganisms and serious complex infections, including infection of S. aureus. Because of its strong activity against anaerobic bacteria, cilastatin is effective in monotherapy of intraabdominal infections. It is used for infectious diseases of the lower respiratory tract, urinary tract, gynecological infections, bacterial septicemia, and infections of the bones, skin, and so on.
DefinitionChEBI: Cilastatin is the thioether resulting from the formal oxidative coupling of the thiol group of L-cysteine with the 7-position of (2Z)-2-({[(1S)-2,2-dimethylcyclopropyl]carbonyl}amino)hept-2-enoic acid. It is an inhibitor of dehydropeptidase I (membrane dipeptidase, 3.4.13.19), an enzyme found in the brush border of renal tubes and responsible for degrading the antibiotic imipenem. Cilastatin is therefore administered (as the sodium salt) with imipenem to prolong the antibacterial effect of the latter by preventing its renal metabolism to inactive and potentially nephrotoxic products. Cilastatin also acts as a leukotriene D4 dipeptidase inhibitor, preventing the metabolism of leukotriene D4 to leukotriene E4. It has a role as a protease inhibitor, an EC 3.4.13.19 (membrane dipeptidase) inhibitor, a xenobiotic and an environmental contaminant. It is a non-proteinogenic L-alpha-amino acid, a L-cysteine derivative, an organic sulfide and a carboxamide. It is a conjugate acid of a cilastatin(1-).
SynthesisCilastatin, (Z)-7-[(2-amino-2-carboethoxyethyl)thio]-2-[[2,2-dimethylcyclopropyl) carbonyl] amino]-2-heptenoic acid (32.1.3.6), is synthesized from the ethyl ester of 1,3-dithian-2-carboxylic acid (which is ethyl glyoxylate, protected at the aldehyde group with 1,3-propanedithiol), which is alkylated by 1,5-dibromopentane in the presence of sodium amide, forming the ethyl ester of 7-bromo-2-[2-(1,3-dithiano)]hepthanoic acid (32.1.3.2). Oxidative hydrolysis of this product with N-bromosuccinimide in a mixture of acetonitrile¨Cwater solvents leads to the formation of the ethyl ester of 7-bromo-|á-ketoheptanoic acid (32.1.3.3). Acidic hydrolysis of this product using hydrogen bromide in acetic acid gives 7-bromo-|á-ketoheptanoic acid (32.1.3.4). This is reacted with 2,2-dimethylcyclopropancarboxylic acid amide to form the corresponding enamide, (Z)-7-bromo-2-(2, 2-dimethylcycloprotancarboxamido)-2-heptenoic acid (32.1.3.5). The resulting product is used for S-alkylation of L-cysteine, which results in the production of the desired cilastatin (32.1.3.6).

Synthesis_82009-34-5

2,2-DIMETHYLCYCLOPROPANE CARBOXAMIDE Cilastatin&imipenem imipenem and cilastatin STERILE CILASTATIN SODIUM CILASTATIN AMMONIUM SALT (100 MG) imipenam-cilastatin sodium mixture,Imipenem hydrate·cilastatin sodium,Imipenem and cilastatin sodium Imipenem-Cilastatin sodium hydrate IMIPENEM CILASTATIN SODIUM Imipenem + Cilastatin Glycine, N-(cyclopropylcarbonyl)- (9CI) intermediate for cilastatin ALTRENOGEST ULINASTATIN STERILE IMIPENEM AND CILASTATIN SODIUM Cilastatin sodium,Sodium Cilastatin AMINO ACIDS CHLOROPHOSPHONAZO III CILASTATIN AMMONIUM SALT (100 MG)G0C334945UG/MG(AI)

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