ChemicalBook Product Catalog API Circulatory system drugs Heart failure Treatments and drugs Enoximone

Enoximone

Enoximone Basic information
Product Name:Enoximone
Synonyms:ENOXIMONE;2H-Imidazol-2-one, 1,3-dihydro-4-methyl-5-(4-(methylthio)benzoyl)-;Fenoximone;MDL-17043;Pedane;Perfan;RMI-17043;4-methyl-5-(4-methylsulfanylbenzoyl)-1,3-dihydroimidazol-2-one
CAS:77671-31-9
MF:C12H12N2O2S
MW:248.3
EINECS:
Product Categories:APIs;API
Mol File:77671-31-9.mol
Enoximone Structure
Enoximone Chemical Properties
Melting point 255-258°C
density 1.33
storage temp. Sealed in dry,Room Temperature
solubility DMSO: 28 mg/mL, soluble
pka10.37±0.70(Predicted)
form solid
color light yellow
CAS DataBase Reference77671-31-9(CAS DataBase Reference)
Safety Information
RIDADR 3249
WGK Germany 3
HazardClass 6.1(b)
PackingGroup III
MSDS Information
ProviderLanguage
Enoximone English
SigmaAldrich English
Enoximone Usage And Synthesis
DescriptionEnoximone is a phosphodiesterase inhibitor indicated for selective use as a cardiostimulant in heart transplant patient maintenance. It is currently being investigated for other indications including acute congestive heart failure.
OriginatorMerrell Dow (USA)
UsesEnoximone is a phosphodiesterase inhibitor used in the treatment of congestive heart failure and is selective to phosphodiesterase 3. Potent PDE-3 inhibitor.
DefinitionChEBI: Enoximone is an aromatic ketone.
Brand namePerfan IV
Biological ActivityInhibitor of type III phosphodiesterase (PDE3). Increases intracellular cyclic AMP (cAMP) concentrations and enhances myocardial contractility. Also induces concentration-dependent vasodilation in vitro .
Biochem/physiol ActionsSelective phosphodiesterase III (PDE3) inhibitor. Prevents the degradation of cAMP by PDE. Increased cAMP results in enhanced contractility of the heart.
storageStore at +4°C
Enoximone Preparation Products And Raw materials
Raw materialsEthyl acetate-->NITROUS ACID
Methylparaben Methyl Hexamethylphosphoramide Enoximone 3-[4-(METHYLTHIO)PHENYL]-1-PROPENE 4,5-DIMETHYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE 4-Ethyl-1,3-dihydro-imidazol-2-one Basic Violet 1 Tribenuron methyl Kresoxim-methyl Imidazole 4-ACETYL-5-METHYL-1,3-DIHYDRO-2H-IMIDAZOL-2-ONE Methanol enoximone sulfoxide Methyl salicylate Methyl acrylate Dihydromyrcenol Phenylmethylsulfonyl fluoride
Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.