(-)-Epigallocatechin gallate

(-)-Epigallocatechin gallate Basic information
Uses
Product Name:(-)-Epigallocatechin gallate
Synonyms:TEA CATECHIN;(-)-Epigallocatechin-3-O-gallate (20 mg);EGCG, (-)-Epigallocatechin gallate/Green Tea EGCG90;EGCG, (-)-Epigallocatechin gallate/Green Tea Extract;(-)-CIS-2-(3,4,5-TRIHYDROXYPHENYL)-3,4-DIHYDRO-1(2H)-BENZOPYRAN-3 ,5,7-TRIOL 3-GALLATE (-)-CIS-3,3',4',5,5',7-HEXAHYDROXY-FLAVANE-3-GALLATE;Epigallocatechin-3-Monogallate;L-Epigallocatechin Gallate;(-)-Epigallocatechin Gallate-d6
CAS:989-51-5
MF:C22H18O11
MW:458.37
EINECS:479-560-7
Product Categories:Aromatics;Heterocycles;Standard extract;Natural Plant Extract;Inhibitors;Amyloid beta-peptide and related;Pharmaceutical Raw Materials;Catechins & Tannins;All Inhibitors;Antioxidant;Biochemistry;Flavonoids;chemical reagent;pharmaceutical intermediate;ProteasomeInhibitors;Plant extracts;Herb extract;Inhibitor;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract;989-51-5
Mol File:989-51-5.mol
(-)-Epigallocatechin gallate Structure
(-)-Epigallocatechin gallate Chemical Properties
Melting point 222-224°C
alpha D -185 ±2°(ethanol)
refractive index -175.5 ° (C=1, EtOH)
storage temp. 2-8°C
solubility H2O: ≥5mg/mL, clear
form neat
Boiling point 909.1±65.0 °C(Predicted)
density 1.90±0.1 g/cm3(Predicted)
pKa7.75±0.25(Predicted)
color White to Light Brown
Water Solubility Soluble in ethanol, dimethyl formamide, water.
Merck 14,3526
Stability:Stable, but may be light sensitive. Incompatible with strong oxidizing agents.
InChIKeyWMBWREPUVVBILR-WIYYLYMNSA-N
LogP0.639 (est)
CAS DataBase Reference989-51-5(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 2
RTECS KB5200000
10-23
HS Code 29339900
ToxicityLD50 oral in mouse: 2170mg/kg
MSDS Information
ProviderLanguage
EGCG English
SigmaAldrich English
(-)-Epigallocatechin gallate Usage And Synthesis
Uses(-)-Epigallocatechin Gallate is a tumor-inhibiting constituent of green tea. (-)-Epigallocatechin Gallate alters the cleavage of amyloid precursor protein, decreasing production of amaloid-ß and amaloid plaques in mice. This compound has neuroprotective properties.
Chemical Propertiessolid
Usestelomerase inhibitor
UsesAn inhibitor of Bcl-2 and NOS2
Uses(-)-Epigallocatechin Gallate is a tumor-inhibiting constituent of green tea. (-)-Epigallocatechin Gallate alters the cleavage of amyloid precursor protein, decreasing production of amaloid-β and amaloid plaques in mice. This compound has neuroprotective properties.
UsesA tumor-inhibiting constituent of green tea. Alters the cleavage of amyloid precursor protein, decreasing production of amaloid- and amaloid plaques in mice
DefinitionChEBI: (-)-epigallocatechin 3-gallate is a gallate ester obtained by the formal condensation of gallic acid with the (3R)-hydroxy group of (-)-epigallocatechin. It has a role as an antineoplastic agent, an antioxidant, a Hsp90 inhibitor, a neuroprotective agent, a plant metabolite, a geroprotector and an apoptosis inducer. It is a gallate ester, a polyphenol and a member of flavans. It is functionally related to a (-)-epigallocatechin.
General DescriptionPharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Epigallocatechin gallate is a potent polyphenolic flavonoid which is found as a component of tea. It exhibits antioxidant, antimutagenic, antitumor and anti-inflammatory properties, thereby contributing to the health-beneficial actions. It finds potential use as a drug candidate in the pharmaceutical, cosmetic, and nutritional fields.
HazardModerately toxic by ingestion.
Biological Activity(-)-epigallocatechin gallate (egcg), the major catechin accounting for 59% of the total catechins in green tea, is a powerful antioxidant as well as an antiangiogenic and antitumor agent. egcg has been studied for its role in the chemoprevention of a wild range of cancers, including liver, stomach, skin, lung, mammary gland and colon cancers. study results show that egcg is able to induce apoptosis, promote cell growth arrest and block carcinogenesis by affecting signal transduction pathways. moreover, egcg exhibits inhibition against a variety of viruses, including hcv, hiv-1, hbv, hsv-1, hsv-2, ebv, adenovirus, influenza virus and enterovirus, as well as several enzymes, including dnmts, proteases and dhfr.singh bn, shankar s, srivastava rk. green tea catechin, epigallocatechin-3-gallate (egcg): mechanisms, perspectives and clinical applications. biochem pharmacol. 2011; 82(12):1807-1821.steinmann j, buer j, pietschmann t, steinmann e. anti-infective properties of epigallocatechin-3-gallate (egcg), a component of green tea. br j pharmacol. 2013; 168(5):1059-1073
Biochem/physiol Actions(-)-Epigallocatechin gallate (EGCG), an antioxidant polyphenol flavonoid exerts anti-tumor properties by inhibiting telomerase and DNA methyltransferase activity. EGCG inhibits the expression of matrix metalloproteinase-2 (MMP-2), MMP-9 and reduces the invasiveness. EGCG blocks the activation of epidermal growth factor (EGF) receptors and human epidermal growth factor receptor-2 (HER-2). EGCG increases bone mineral density and reduces bone resorption. EGCG inhibits osteoclastogenesis by inhibiting receptor activator of nuclear factor κ-B ligand (RANKL) induced nuclear factor κ B (NF-κB) transcriptional activity. EGCG reduces skeletal muscle atrophy. EGCG has anti-aging property and increases myogenic differentiation. EGCG inhibits fatty acid synthase and glutamate dehydrogenase activity.
Anticancer ResearchEGCG and EGC are the active polyphenol compounds found in green tea, found toinhibit p-glycoprotein transport activities in Chinese hamster ovary (p-gp+) cells.EGCG facilitates the retraction of MDR phenotype by reducing cellular drug effluxwhen given in combination with vinblastine or doxorubicin. Hesperetin, quercetin,daidzein, silymarin, naringenin, and resveratrol also inhibit the MRP1, MRP4, andMRP5 (Kawasaki et al. 2008). Curcumin increases the cellular accumulation ofanticancer agents like cisplatin, tamoxifen, daunorubicin, vincristine, anddoxorubicin and thereby effectively sensitizes the drug-resistant cancer cells. Areduction in MDR1B expression in L1210/Adr cells (mouse leukemic MDR cells)by curcumin is mediated by PI3K, Akt, and NF-κB pathways. It also inhibits theABCG2 transporter activity. In addition curcumin facilitates the accumulation ofmitoxantrone and doxorubicin in ABCG2-expressing HEK cells and hence reversesMDR (Kawasaki et al. 2008; Dandawate et al. 2013).
Anticancer ResearchEGCG is an ester of gallic acid and epigallocatechin and is a catechin compound(Murakami et al. 1996). It is found most abundantly in green tea. It can be used to treat brain, prostate, cervical, and bladder cancers (Wang et al. 2012). It suppressesthe ornithine decarboxylase action, an enzyme that leads to rapid proliferation andfurthermore circumvents apoptosis (Singh et al. 2016a). It suppresses nuclear factor(NF-κB) activation and expression of Bcl-2 (B-cell lymphoma 2) as well as COX-2(cyclooxygenase-2) in prostate cancer cells and causes induction of apoptosis. Ithamper the matrix metallopeptidase-9 (MMP-9) activation in bladder and lungcancer cells and suppresses the synthesis of VGEF (vascular endothelial growthfactor) in head and neck cancers. It prevents ERK (extracellular signal-regulatedkinase) phosphorylation and MMP-2 and MMP-9 activation and suppresses ERK,c-Jun N-terminal kinase (JNK), and MMP-9 expressions in gastric carcinoma cells(Singh et al. 2016a). It is binding and inhibits the antiapoptotic protein Bcl-xL,interferes with EGFR (epidermal growth factor receptor) signaling, and inhibitshepatocyte growth factor-induced cell proliferation and MAPK (mitogen-activatedprotein kinase), CDK (cyclin-dependent kinase), and cell signaling linked to growthfactors (Wang et al. 2012; Du et al. 2012).
Green tea constitutes the rich amount of EGCG which aids in cancer chemoprevention(Fujiki et al. 1998). EGCG improved the impacts of ginseng compoundin the restraint of colon tumor cell development, showing that green tea could bea successful synergist with an anticancer agent for malignancy chemoprevention.It obstructs the PDGF-initiated proliferation and migration of rodent pancreaticstellate cells (Masamune et al. 2005). The soluble and plasma membrane-integratedEGCG straightforwardly communicates with PDGF-BB and in this wayputs off precise receptor binding promoting the inhibitory impacts of EGCG onplatelet-derivedgrowth factor-incited cell signaling and mitogens (Weber et al.2004).
storageStore at -20°C
(-)-Epigallocatechin gallate Preparation Products And Raw materials
Methyl gallate L-Epicatechin (-)-EGCG-3''-O-ME Polyvinylpyrrolidone cross-linked Propyl gallate (-)-EPIGALLOCATECHIN 3-(4''-O-METHYL)GALLATE Epigallocatechin gallate solution,Epigallocatechin gallate solution (-)-Epigallocatechin gallate GREEN TEA EXTRACT/ POLYPHENOL/ EPIGALLOCATECHIN GALLATE,GREEN TEA EXTRACT/ POLYPHENOL/ EPIGALLOCATECHIN GALLATE (-)-EGCG-4'-O-ME PRODELPHINIDIN B2 3'-O-GALLATE (-)-EPIGALLOCATECHIN GALLATE, [3H(G)],(-)-EPIGALLOCATECHIN GALLATE, [3H(G)] Pyrogallol (-)-EGCG-3'-O-ME (-)-Gallocatechin gallate Gallic acid monohydrate Dihydromyrcenol OCTANICOTINOYL EPIGALLOCATECHIN GALLATE,OCTANICOTINOYL EPIGALLOCATECHIN GALLATE

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