ChemicalBook Product Catalog Analytical Chemistry Standard Pharmaceutical Impurity Reference Standards 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]

4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]

4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Basic information
Product Name:4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER]
Synonyms:4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER];4-butyl-4-(beta-carboxypropionyl-oxymethyl)-1,2-diphenyl-3,5-pyrazolidinedio;4-butyl-4-hydroxymethyl-1,2-diphenyl-3,5-pyrazolidinedionehydrogensuccinate;ae-17;alfide;SUXIBUZONE;Acetanilide Impurity 1;butanedioicacid,mono((4-butyl-3,5-dioxo-1,2-diphenyl-4-pyrazolidinyl)methyl
CAS:27470-51-5
MF:C24H26N2O6
MW:438.47
EINECS:248-477-6
Product Categories:DANILON
Mol File:27470-51-5.mol
4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Structure
4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Chemical Properties
Melting point 126-127°
Boiling point 550.33°C (rough estimate)
density 1.2847 (rough estimate)
refractive index 1.6300 (estimate)
storage temp. 2-8°C
solubility Practically insoluble in water, freely soluble in acetone, soluble in ethanol (96 per cent), practically insoluble in cyclohexane.
form neat
pka4.33±0.17(Predicted)
color White to Off-White
CAS DataBase Reference27470-51-5
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22
Safety Statements 36
WGK Germany 3
RTECS WM9640000
ToxicityLD50 orally in mice: 5.683 micromol/kg (Esteve, 1973)
MSDS Information
ProviderLanguage
SigmaAldrich English
4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Usage And Synthesis
Chemical PropertiesWhite or almost white, crystalline powder.
Usesanalgesic, antipyretic, antiinflammatory
UsesSuxibuzone is a prodrug of the non steroidal anti inflammatory drug phenylbutazone. It is a drug used for joint and muscular pain.
DefinitionChEBI: A pyrazolidine that is phenylbutazone which is substituted by a 3-carboxypropanoylmethyl group at the 4-position. Suxibuzone is a prodrug for phenylbutazone and is commonly used as an anti-inflammatory drug in horses.
Brand nameCalibene;Danalon om;Danilon;Flamilon;Flofos.
World Health Organization (WHO)Suxibuzone, a pyrazolone derivative with anti-inflammatory, analgesic and antipyretic activity, was introduced in 1974 for the treatment of rheumatic disorders. As it is structurally related to phenylbutazone, it is subjected to rigorously restricted indications by some national regulatory authorities. See WHO comment for phenylbutazone.
Biochem/physiol ActionsA prodrug of phenylbutazone.
4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] Preparation Products And Raw materials
MALONANILIDE Phenylbutazone MOFEBUTAZONE 4-BUTYL-4-[HYDROXYMETHYL]-1,2-DIPHENYL-3,5-PYRAZOLIDINEDIONE HYDROGEN SUCCINATE [ESTER] 2,2,2-TRIMETHYLACETANILIDE Dimezone S 1,2-DIPHENYL-PYRAZOLIDINE-3,5-DIONE 3-AMINO-2,2-DIMETHYL-1-PROPANOL 1,2-Diphenylhydrazine Phenidone 3-METHOXY-2,2-DIMETHYLPROPYLAMINE 1-Phenyl-4-methyl-3-pyrazolidone 4,4-Dimethyl-1-phenyl-3-pyrazolidone 1-Acetyl-2-phenylhydrazine N,N'-dimethylmalonamide 2,2-Dimethylpropionic acid hydrazide 3-METHOXYPROPIONIC ACID HYDRAZIDE 2,2-dimethyl-3-(methylamino)propan-1-ol
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