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| | NS-398 Chemical Properties |
| Melting point | 124-126 °C(Solv: ethyl acetate (141-78-6); hexane (110-54-3)) | | Boiling point | 490.6±55.0 °C(Predicted) | | density | 1.377±0.06 g/cm3(Predicted) | | RTECS | PB0473500 | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO: >5 mg/mL | | form | solid | | pka | 6.33±0.10(Predicted) | | color | off-white |
| Safety Statements | 22-24/25 | | WGK Germany | 3 | | HS Code | 2935.90.9500 |
| | NS-398 Usage And Synthesis |
| Description | NS-398 is a selective inhibitor of cyclooxygenase-2 (COX-2). The IC50 values for human recombinant COX-1 and -2 are 75 and 1.77 μM, respectively. The IC50 values for ovine COX-1 and -2 are 220 and 0.15 μM, respectively. | | Uses | NS-398 is a selective Cox-2 inhibitor neuroprotective agent. | | Definition | ChEBI: A C-nitro compound that is N-methylsulfonyl-4-nitroaniline bearing an additional cyclohexyloxy substituent at position 2. | | Biological Activity | Selective cyclooxygenase-2 inhibitor (IC 50 values are 3.8 and > 100 μ M for COX-2 and COX-1 respectively). Induces apoptosis in colorectal tumor cells and elevates COX-2 protein expression in vitro . Orally active and non-ulcerogenic analgesic and anti-inflammatory in vivo . | | storage | Store at RT | | references | [1]. futaki n, takahashi s, yokoyama m, et al. ns-398, a new anti-inflammatory agent, selectively inhibits prostaglandin g/h synthase/cyclooxygenase (cox-2) activity in vitro. prostaglandins, 1994, 47(1): 55-59.
[2]. elder dj, halton de, crew te, et al. apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug ns-398. int j cancer, 2000, 86(4): 553-560.
[3]. mack strong ve, mackrell pj, concannon em, et al. ns-398 treatment after trauma modifies nf-kappab activation and improves survival. j surg res, 2001, 98(1): 40-46. |
| | NS-398 Preparation Products And Raw materials |
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