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| | Pyridine-2,6-dicarboxylic acid Basic information |
| Product Name: | Pyridine-2,6-dicarboxylic acid | | Synonyms: | Pyridine-2,6-dicarboxylic acid 98%;2,6-Pyridinedicarboxylic acid solution, Eluent concentrate for IC, 0.02M in water;2,6-PyridinedicarboxylicAcid99%;Pyridine-2,6-dicarboxylicacid,98%;IFLAB-BB F0451-0137;LABOTEST-BB LT00848023;RARECHEM AL BO 1335;PYRIDINE-2,6-DICARBOXYLIC ACID | | CAS: | 499-83-2 | | MF: | C7H5NO4 | | MW: | 167.12 | | EINECS: | 207-894-3 | | Product Categories: | Building Blocks;C7;Carboxylic Acids;Carboxylic Acids;Chemical Synthesis;Heterocyclic Building Blocks;blocks;Carboxes;Pyridines;Pyridine;pyridine derivative;Pyridines, Pyrimidines, Purines and Pteredines;Organic acids;bc0001;499-83-2 | | Mol File: | 499-83-2.mol |  |
| | Pyridine-2,6-dicarboxylic acid Chemical Properties |
| Melting point | 248-250 °C (dec.)(lit.) | | Boiling point | 295.67°C (rough estimate) | | density | 1.5216 (rough estimate) | | vapor pressure | <0.01 hPa (20 °C) | | refractive index | 1.6280 (estimate) | | Fp | 188 °C | | storage temp. | Store below +30°C. | | solubility | H2O: 1%, clear | | pka | 2.16(at 25℃) | | form | Crystalline Powder | | color | White | | PH | 2.0 (5g/l, H2O, 20℃) | | Water Solubility | 5 g/L (20 ºC) | | BRN | 131629 | | InChIKey | WJJMNDUMQPNECX-UHFFFAOYSA-N | | LogP | 0.3 at 25℃ and pH1.8 | | CAS DataBase Reference | 499-83-2(CAS DataBase Reference) | | NIST Chemistry Reference | 2,6-Pyridinedicarboxylic acid(499-83-2) | | EPA Substance Registry System | 2,6-Pyridinedicarboxylic acid (499-83-2) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38-37/38-36 | | Safety Statements | 26-36-24/25-37 | | WGK Germany | 3 | | Autoignition Temperature | 620 °C | | TSCA | T | | HazardClass | IRRITANT | | HS Code | 29333999 | | Toxicity | LD50 orally in Rabbit: 10500 mg/kg |
| | Pyridine-2,6-dicarboxylic acid Usage And Synthesis |
| Chemical Properties | White crystalline powder. Insoluble in ethanol. | | Uses | Pyridine-2,6-dicarboxylic acid is used in the preparation of dipicolinato ligated lanthanide and transition metal complexes. It acts as a chelating agent for chromium, zinc, manganese, copper, iron and molybdenum. Its calcium-dipcolinic acid complex is used to protect deoxyribonucleic acid (DNA) from heat denaturation which enhances the DNA stability. It plays an important role as a marker for the effectiveness of sterilization. | | Definition | ChEBI: Pyridine-2,6-dicarboxylic acid is a pyridinedicarboxylic acid carrying two carboxy groups at positions 2 and 6. It has a role as a bacterial metabolite. It is a conjugate acid of a dipicolinate(1-). | | Application | 2,6-Pyridinedicarboxylic acid is an amphoteric polar metabolite produced by many bacterial and fungal species. Prior to its discovery as a microbial metabolite, dipicolinic acid had long been recognised as a chelating agent for many metal ions. Wide distribution of dipicolinic acid among microbes makes it an important dereplication standard in discovery. Dipicolinic acid reaches high concentrations (~10% w/w) in Bacillus endospores aiding heat resistance and is used in laboratories as a marker for the effectiveness of sterilisation. | | Preparation | pyridine-2,6-dicarboxylic acid was synthesized by hydrolyzing of ester prepared by coupling of diethyl 4-hydroxypyridine-2,6-dicarboxylate to bis-halohydrocarbon or bis-halide.
Synthesis of Novel Derivatives of Pyridine‐2,6‐dicarboxylic Acid | | Synthesis Reference(s) | Synthetic Communications, 22, p. 2691, 1992 DOI: 10.1080/00397919208021669 | | General Description | This certified eluent concentrate for ion chromatography is traceable by potentiometric titration to NIST Standard Reference Material. It is certified in accordance with ISO Guide 31. All details about exact content, uncertainty, traceability and expiry date are described in the certificate. |
| | Pyridine-2,6-dicarboxylic acid Preparation Products And Raw materials |
| Raw materials | Ethyl acetate-->Sulfuric acid-->Potassium permanganate-->2,6-Lutidine-->Heptanedioic acid, 2,6-dioxo--->6-Methyl-2-pyridinecarboxaldehyde-->6-(4-FLUOROPHENYL)PYRIDINE-2-CARBALDEHYDE-->dichromic acid-->DIMETHYL PIMELATE-->trans-Cinnamic acid | | Preparation Products | 2,6-Diacetylpyridine-->6-(TERT-BUTOXYCARBONYLAMINO-METHYL)-PYRIDINE-2-CARBOXYLIC ACID-->2,6-DIAMINO-4-CHLOROPYRIDINE-->Methyl 6-methoxyformamido-4-chloropyridin-2-ylcarbamate ,97%-->6-(AMINOMETHYL)-2-PYRIDINE CARBOXYLIC ACID-->4-CHLOROPYRIDINE-2,6-DICARBOHYDRAZIDE-->DIMETHYL 4-CHLOROPYRIDINE-2,6-DICARBOXYLATE-->6-(AMINOMETHYL)PYRIDINE-2-CARBOHYDRAZIDE-->DIMETHYL 2,6-PYRIDINEDICARBOXYLATE-->ETHYL 6-(CHLOROMETHYL)PYRIDINE-2-CARBOXYLATE-->ETHYL 6-(HYDROXYMETHYL)PYRIDINE-2-CARBOXYLATE-->4-CHLORO-PYRIDINE-2,6-DICARBOXYLIC ACID-->2,6-Pyridinedicarboxylic acid chloride |
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