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ETANIDAZOLE

ETANIDAZOLE Basic information
Product Name:ETANIDAZOLE
Synonyms:N-[2-HYDROXYETHYL]-2-NITRO-1H-IMIDAZOLE-1-ACETAMIDE;ETANIDAZOLE;n-(2-hydroxyethyl)-1-(2-nitro-1-imidazolyl)acetamide;n-(2-hydroxyethyl)-2-nitro-1h-imidazole-1-acetamid;n-(2-hydroxyethyl)-2-nitro-imidazole-1-acetamid;nsc301467;Radinyl;SP-2508
CAS:22668-01-5
MF:C7H10N4O4
MW:214.18
EINECS:
Product Categories:
Mol File:22668-01-5.mol
ETANIDAZOLE Structure
ETANIDAZOLE Chemical Properties
Melting point 162-163° (Beaman); mp 164.5-165° (Lee)
Boiling point 354.3°C (rough estimate)
density 1.4480 (rough estimate)
refractive index 1.6700 (estimate)
storage temp. 2-8°C
solubility Acetone (Slightly), Methanol (Slightly)
form Solid
pka13.74±0.46(Predicted)
color White to Off-White
Stability:Hygroscopic
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
RTECS NI3355000
MSDS Information
ProviderLanguage
SigmaAldrich English
ETANIDAZOLE Usage And Synthesis
UsesAntineoplastic (hypoxic cell radiosensitizer).
UsesEtanidazole is a kind of hypoxic radiosensitizer (a drug that sensitizes tumour cells to radiation therapy). Etanidazole is used in conjunction with Paclitaxel (P132500) to treat glioma, and is also used with Carboplatin (C177500) to treat advanced ovarian cancer.
DefinitionChEBI: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitro-1H-imidazol-1-yl)acetic acid with the amino group of ethanolamine. Used as a radiosensitising agent for hypoxic tumour cells.
Brand nameRadinyl (Roberts Pharmaceutical).
ETANIDAZOLE Preparation Products And Raw materials
Raw materialsMETHYL 2-NITRO-1-IMIDAZOLEACETATE-->Monoethanolamine
Metronidazole gel Morpholinazole Tinidazole Ornidazole ETANIDAZOLE 1-methyl-2-nitrosoimidazole 1-methyl-2-nitroimidazole 2-nitro-1H-imidazole
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