Nebivolol

Nebivolol Basic information
Product Name:Nebivolol
Synonyms:NEBIVOLOL-D4;1-(6-fluorochroman-2-yl)-2-[[2-(6-fluorochroman-2-yl)-2-hydroxy-ethyl]amino]ethanol;Nibivolol;R-65824;α,α'-(Iminobismethylene)bis(6-fluoro-2-chromanmethanol);2,2'-iminobis[1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)ethanol];Nebivolol;1-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-[[2-(6-fluoro-3,4-dihydro-2H-chromen-2-yl)-2-hydroxyethyl]amino]ethanol
CAS:99200-09-6
MF:C22H25F2NO4
MW:405.43
EINECS:
Product Categories:Antihypertensive
Mol File:99200-09-6.mol
Nebivolol Structure
Nebivolol Chemical Properties
Boiling point 600.5±55.0 °C(Predicted)
density 1.309±0.06 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility DMSO (Slightly), Methanol (Slightly, Heated)
form Solid
pka14.29±0.20(Predicted)
color White to Off-White
InChIKeyKOHIRBRYDXPAMZ-AWIIVWKDNA-N
SMILESC([2H])([2H])([C@H](O)[C@@]1([H])CCC2C=C(C=CC=2O1)F)NC([2H])([2H])[C@H](O)[C@]1([H])CCC2C=C(C=CC=2O1)F |&1:3,5,21,23,r|
CAS DataBase Reference99200-09-6(CAS DataBase Reference)
Safety Information
MSDS Information
Nebivolol Usage And Synthesis
DescriptionNebilet was launched in Germany and the Netherlands as an antihypertensive agent. It is prepared by a five step route starting with 6-fluoro-4- oxobenzopyran-2-carboxylic acid. It is a selective β1-adrenergic receptor antagonist and is 50 times less potent at β2-receptors. Vasodialating properties occur via the nitric oxide pathway. While the L-isomer is more potent than the D-isomer, the racemic mixture is necessary for optimal activity. Upon administration, an immediate fall in blood pressure occurs, it improves both left ventricular systolic and diastolic function, and lowers peripheral blood resistance. Nebilet does not influence insulin sensitivity nor lipid profile comparible to atenolol. Doses of 50 mg of atenolol and 10 mg of Nebilet are equipotent but Nebilet has a longer duration of action due to an accumulation of the drug and increasing plasma levels of active metabolites.
OriginatorJohnson & Johnson (US)
UsesLabeled Nebivolol, intended for use as an internal standard for the quantification of Nebivolol by GC- or LC-mass spectrometry.
UsesNebivolol is a cardioselective beta-1 receptor blocking agent.
DefinitionChEBI: A member of the class of chromanes that is 2,2'-iminodiethanol in which one hydrogen attached to each hydroxy-bearing carbon is replaced by a 6-fluorochroman-2-yl group.
Brand nameNebilet
Nebivolol Preparation Products And Raw materials
Preparation ProductsNEBIVOLOL
Propanolol Nebivolol (+)-Nebivolol Ethanol Diethylenetriamine Atenolol Metoprolol 2-(2-Aminoethylamino)ethanol 1-Hydroxyethylidene-1,1-diphosphonic acid Ethylparaben Diethyltoluenediamine Esmolol Bisoprolol Ethyl acrylate (-)-Nebivolol CHLOROPHOSPHONAZO III Nebivolol Nebivolol hydrochloride

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