Saccharin sodium dihydrate

Saccharin sodium dihydrate Basic information
Product Name:Saccharin sodium dihydrate
Synonyms:O-BENZOIC ACID SULFIMIDE SODIUM SALT DIHYDRATE;SODIUM SACCHARINE USP;SODIUM SACCHARINE BP 88/93;SODIUM SACCHARINE 450 X BP;SODIUM SACCRINE GRANULER;SACCHARINSODIUM,DIHYDRATE,GRANULAR,USP;SACCHARINSODIUM,GRANULAR,FCC;SACCHARINSODIUM,POWDER,USP
CAS:6155-57-3
MF:C7H8NNaO4S
MW:225.19
EINECS:612-173-5
Product Categories:FOOD ADDITIVES;Food & Flavor Additives;pharmacetical;Fine chemicals
Mol File:6155-57-3.mol
Saccharin sodium dihydrate Structure
Saccharin sodium dihydrate Chemical Properties
Melting point > 300℃
Fp >200°C
storage temp. 2-8°C
solubility 1000g/l
form powder to crystaline
color White to Almost white
PH6.0-7.5 (100g/l, H2O, 20℃)
Water Solubility Soluble in water. Slightly soluble in alcohol
Merck 14,8311
InChIKeyBCWVKFPXENUOQA-UHFFFAOYSA-N
CAS DataBase Reference6155-57-3(CAS DataBase Reference)
Safety Information
Risk Statements 22
Safety Statements 24/25
WGK Germany 2
RTECS DE4375000
TSCA Yes
HS Code 29350090
ToxicityLD50 orally in Rabbit: 14200 mg/kg
MSDS Information
ProviderLanguage
Sodium ortho-sulphobenzimide dihydrate English
ALFA English
Saccharin sodium dihydrate Usage And Synthesis
DescriptionSaccharin sodium dihydrate is the sodium dihydrate form of saccharin, which belongs to the family of aromatic homomonocyclic compounds. It is an artificial sweetener that is hundreds times as sweet as sucrose. It is mainly used as a food additive to sweeten many products such as drinks, candies, cookies, and medicine. Saccharin is relatively safe for human beings without providing food energy and any nutritional value. It is also safe for diabetes patients to consume.
Chemical Propertiesdihydrate granular
Chemical PropertiesSaccharin sodium occurs as a white, odorless or faintly aromatic, efflorescent, crystalline powder. It has an intensely sweet taste, with a metallic or bitter aftertaste that at normal levels of use can be detected by approximately 25% of the population. The aftertaste can be masked by blending saccharin sodium with other sweeteners. Saccharin sodium can contain variable amounts of water.
UsesSaccharin Sodium Salt Dihydrate is a non-nutritive sweetener; pharmaceutic aid (flavor). Saccharin was formerly listed as reasonably anticipated to be a human carcinogen; delisted because the cancer data are not sufficient to meet the current criteria for this listing.
UsesSweetener (non-nutritive).
Production MethodsSaccharin is produced by the oxidation of o-toluene sulfonamide by potassium permanganate in a solution of sodium hydroxide. Acidification of the solution precipitates saccharin, which is then dissolved in water at 50℃ and neutralized by addition of sodium hydroxide. Rapid cooling of the solution initiates crystallization of saccharin sodium from the liquors.
Brand nameSucaryl (Ross).
Pharmaceutical ApplicationsSaccharin sodium is an intense sweetening agent used in beverages, food products, table-top sweeteners, and pharmaceutical formulations such as tablets, powders, medicated confectionery, gels, suspensions, liquids, and mouthwashes. It is also used in vitamin preparations.
Saccharin sodium is considerably more soluble in water than saccharin, and is more frequently used in pharmaceutical formulations. Its sweetening power is approximately 300–600 times that of sucrose. Saccharin sodium enhances flavor systems and may be used to mask some unpleasant taste characteristics.
Injection of saccharin sodium has been used to measure the armto- tongue circulation time.

SafetyThere has been considerable controversy concerning the safety of saccharin and saccharin sodium in recent years; however, it is now generally regarded as a safe, intense sweetener. See Saccharin for further information.
The WHO has set a temporary acceptable daily intake of up to 2.5 mg/kg body-weight for saccharin, including its salts.(3) In the UK, the Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment (COT) has set an acceptable daily intake for saccharin and its salts (expressed as saccharin sodium) at up to 5 mg/kg body-weight.
LD50 (mouse, oral): 17.5 g/kg
LD50 (rat, IP): 7.1 g/kg
LD50 (rat, oral): 14.2 g/kg



storageSaccharin sodium is stable under the normal range of conditions employed in formulations. Only when it is exposed to a high temperature (125℃) at a low pH (pH 2) for over 1 hour does significant decomposition occur. The 84% grade is the most stable form of saccharin sodium since the 76% form will dry further under ambient conditions. Solutions for injection can be sterilized by autoclave.
Saccharin sodium should be stored in a well-closed container in a dry place.
IncompatibilitiesSaccharin sodium does not undergo Maillard browning.
Regulatory StatusAccepted for use as a food additive in Europe; ‘E954’ is applied to both saccharin and saccharin salts. Included in the FDA Inactive Ingredients Database (buccal and dental preparations; IM and IV injections; oral and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Referenceshttps://en.wikipedia.org/wiki/Saccharin
https://pubchem.ncbi.nlm.nih.gov/compound/saccharin#section=Top
Saccharin sodium dihydrate Preparation Products And Raw materials
Raw materialsAmmonium hydroxide-->Sodium hypochlorite-->Water-->Copper(II) sulfate-->Methyl anthranilate-->Saccharin-->Methyl 2-(chlorosulfonyl)benzoate-->2-Aminobiphenyl
Saccharin Saccharin sodium Sodium N-cyclohexylsulfamate 2-Nitrobenzenesulfonyl chloride Sodium benzoate Saccharin sodium dihydrate O-Phthalimide sodium SACCHARIN SODIUM SALT DIHYDRATE Phthalhydrazide Trisodium phosphate Diclofenac sodium Sodium bicarbonate Sodium hydroxide N,N'-1,3-Phenylene bismaleimide 2-Methoxyphenylacetic acid FOROXYMITHINE Phenylmethylsulfonyl fluoride

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