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Betanidine

Betanidine Basic information
Product Name:Betanidine
Synonyms:Betanidine;Bethanidine;1-Benzyl-2,3-dimethylguanidine;N,N'-Dimethyl-N''-(phenylmethyl)guanidine;2-benzyl-1,3-diMethylguanidine;BETANIDIN;Guanidine, N,N''-dimethyl-N'-(phenylmethyl)-;Betanidine USP/EP/BP
CAS:55-73-2
MF:C10H15N3
MW:177.25
EINECS:
Product Categories:
Mol File:55-73-2.mol
Betanidine Structure
Betanidine Chemical Properties
Melting point 195-197°
Boiling point 299.18°C (rough estimate)
density 0.9826 (rough estimate)
refractive index 1.4800 (estimate)
pkapKa 10.6 (Uncertain)
Safety Information
MSDS Information
Betanidine Usage And Synthesis
OriginatorBendogen,Lagap Pharmaceuticals SA
UsesBetanidine is a betacyanin and an aglycone of the beet dye betanin.
DefinitionChEBI: Bethanidine is a member of guanidines. It has a role as an adrenergic antagonist and an antihypertensive agent.
Manufacturing ProcessA mixture of 2-bromobenzylamine (12.5 g) and S-methylthiouronium sulfate (10 g) in water (20 ml) was heated for 1.5 hours on a steam bath in a hood, during which methylmercaptan escaped (as evidenced by a foul odour). The reaction mixture was then cooled and diluted with ethanol (100 ml). A colourless solid of 2-bromobenzylguanidine sulfate was separeted, and washed with ethanol. This solid melted at 230-232°C; it was recrystallized from water and then melted at 247-248°C. By action of a basic agent the salt obtained may be converted into free base.
Therapeutic FunctionAntihypertensive
Betanidine Preparation Products And Raw materials
Raw materials2-METHYL-2-THIOPSEUDOUREA SULFATE-->2-BROMOBENZYLAMINE
2-(6-OXO-4-PHENYL-1,6-DIHYDRO-2-PYRIMIDINYL)-1,2,4,5,6,7-HEXAHYDRO-3H-INDAZOL-3-ONE N-{(1E)-[(4,6-DIMETHYLPYRIMIDIN-2-YL)AMINO][(2-METHOXYPHENYL)AMINO]METHYLENE}BENZAMIDE 2-(4-BENZYL-3-METHYL-5-OXO-2,5-DIHYDRO-1H-PYRAZOL-1-YL)-6-PHENYL-4(3H)-PYRIMIDINONE N-{(1E)-[(4,6-DIMETHYLPYRIMIDIN-2-YL)AMINO][(4-METHOXYPHENYL)AMINO]METHYLENE}BENZAMIDE BUTTPARK 111\40-44 2-[4-(2-HYDROXYETHYL)-3-METHYL-5-OXO-2,5-DIHYDRO-1H-PYRAZOL-1-YL]-6-PHENYL-4(3H)-PYRIMIDINONE behenyltrimethylammonium methosulfate BUTTPARK 111\40-79 2-(5-OXO-3-PHENYL-2,5-DIHYDRO-1H-PYRAZOL-1-YL)-6-PHENYL-4(3H)-PYRIMIDINONE (E)-N-((3-CHLOROPHENYLAMINO)(4,6-DIMETHYLPYRIMIDIN-2-YLAMINO)METHYLENE)-3,4,5-TRIMETHOXYBENZAMIDE BUTTPARK 111\40-78 BUTTPARK 111\40-77 N-{(1E)-[(4,6-DIMETHYLPYRIMIDIN-2-YL)AMINO][(3-METHYLPHENYL)AMINO]METHYLENE}BENZAMIDE 6-(2-FLUOROPHENYL)-2-[4-(2-HYDROXYETHYL)-3-METHYL-5-OXO-2,5-DIHYDRO-1H-PYRAZOL-1-YL]-4(3H)-PYRIMIDINONE N-[(1Z)-(1,3-BENZOXAZOL-2-YLAMINO)(BENZOYLAMINO)METHYLENE]BENZAMIDE RARECHEM AQ NN 0471 N-{(1E)-ANILINO[(4,6-DIMETHYLPYRIMIDIN-2-YL)AMINO]METHYLENE}BENZAMIDE BUTTPARK 111\40-81
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