2-Nitroanisole

2-Nitroanisole Basic information
Product Name:2-Nitroanisole
Synonyms:1-methoxy-2-nitro-benzen;1-Nitro-2-methoxybenzene;2-NITROANISOL;2-NITROANISOLE;2-METHOXYNITROBENZENE;1-METHOXY-2-NITROBENZENE;2-Methoxy-1-nitrobenzene;Anisole, o-nitro-
CAS:91-23-6
MF:C7H7NO3
MW:153.14
EINECS:202-052-1
Product Categories:Building Blocks;Chemical Synthesis;Intermediates of Dyes and Pigments;Nitro Compounds;Nitrogen Compounds;Organic Building Blocks
Mol File:91-23-6.mol
2-Nitroanisole Structure
2-Nitroanisole Chemical Properties
Melting point 9-12 °C (lit.)
Boiling point 273 °C (lit.)
density 1.254 g/mL at 25 °C (lit.)
refractive index n20/D 1.561(lit.)
Fp >230 °F
storage temp. Refrigerator, Under Inert Atmosphere
solubility alcohol: soluble(lit.)
form Oil
color Pale Yellow
Specific Gravity1.254
Water Solubility 1.45 g/L (20 ºC)
Merck 14,6584
BRN 1868032
Stability:Stable. Incompatible with strong oxidizing agents.
CAS DataBase Reference91-23-6(CAS DataBase Reference)
IARC2A (Vol. 65, 127)
NIST Chemistry ReferenceBenzene, 1-methoxy-2-nitro-(91-23-6)
EPA Substance Registry Systemo-Nitroanisole (91-23-6)
Safety Information
Hazard Codes T
Risk Statements 45-22
Safety Statements 53-45
RIDADR UN 2730 6.1/PG 3
WGK Germany 3
RTECS BZ8790000
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29093090
Hazardous Substances Data91-23-6(Hazardous Substances Data)
MSDS Information
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2-Nitroanisole English
SigmaAldrich English
ACROS English
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2-Nitroanisole Usage And Synthesis
Chemical Propertiesyellow to amber liquid
Chemical Properties2-Nitroanisole is a yellowish or light-red to amber liquid. May be transported in molten form.
Uses2-Nitroanisole is an intermediate in the synthesis of various potential therapeutic compounds.
Uses2-Nitroanisole has been employed as solvatochromic probe to examine cybotactic region of pure and mixed supercritical fluid solvent systems.
DefinitionChEBI: A member of the class of 2-nitroanisoles that is anisole in which one of the hydrogens ortho to the methoxy group is replaced by a nitro group.
Synthesis Reference(s)Tetrahedron Letters, 29, p. 4501, 1988 DOI: 10.1016/S0040-4039(00)80531-6
General Description2-Nitroanisole (2-methoxynitrobenzene is an industrial and environmental pollutant causing tumors of the urinary bladder in rats and mice. Tumorigenic potential of 2-nitroanisole has been evaluated by host-mediated in vitro and in vivo assay.
HazardQuestionable carcinogen.
Safety ProfileConfirmed carcinogen. Moderately toxic by ingestion. Mutation data reported. Explosive reaction with sodium hydroxide + zinc. Vigorous reaction with hydrogen + catalyst (at 250°C/34bar). When heated to decomposition it emits toxic fumes of NOx. See also p- NITROANISOLE.
Potential ExposureA dye intermediate and for synthesis of other chemicals. NFPA has reported an explosion on during reduction with a nickel catalyst. Occupational exposure to 2-nitroanisole may occur through inhalation and dermal contact with this compound at workplaces where the chemical is produced or used.
Carcinogenicityo-Nitroanisole is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.
ShippingUN2730 Nitroanisoles, liquid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials. UN3458 Nitroanisoles, solid, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Purification MethodsPurify it by repeated vacuum distillation in the absence of oxygen. [Beilstein 6 IV 1249.]
IncompatibilitiesA strong oxidizer. Incompatible with strong acids; sulfur, combustibles, organics, and other easily oxidizable materials. Will accelerate the burning of combustible materials. If large quantities are involved in a fire or the combustible material is finely divided, an explosion may result. Prolonged exposure to fire or heat may result in an explosion. Explodes at temperatures >110℃. Combustible-liquid or fine powder may form explosive mixture with air. Nitroanisole reacts explosively with (sodium hydroxide + zinc). It reacts vigorously with hydrogen1 catalyst (@ 250℃ & 25,500 mmHg).
Waste DisposalUse a licensed professional waste disposal service to dispose of this material. Dissolve or mix the material with a combustible solvent and burn in a chemical incinerator equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
2-NITROPHENYL CHLOROFORMATE 5-METHOXY-2-METHYL-4-NITROANILINE, TECH., 95 2,5-Dimethoxy-4-nitroaniline 3-Methyl-2-nitroanisole 4-Methoxy-3-nitrobenzoic acid Methoxy Sodium 3-nitrobenzenesulphonate 3-METHOXY-4-NITROBENZYL ALCOHOL p-Nitrobenzoic acid 3-METHOXY-2-NITROBENZOIC ACID 2'-NITROPHENYL-2-ACETAMIDO-2-DEOXY-ALPHA-D-GLUCOPYRANOSIDE 2-Methoxyethanol 1-Methoxy-2,4-dinitrobenzene 3-Nitroanisole 3-Nitrobenzaldehyde 3-Methoxy-4-nitrobenzoic acid Nitrobenzene 1,3-Dinitrobenzene

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