Benactyzine

Benactyzine Basic information
Product Name:Benactyzine
Synonyms:2-diethylaminoethyl 2-hydroxy-2,2-diphenyl-acetate;benactyzine;Benactyzine (base and/or unspecified salts);2-Diethylaminoethyl benzilate;Benzilic acid, 2-(diethylamino)ethyl ester;Diethylaminoethyl benzilate;Benactyzin;Diphenylglycolic acid 2-(diethylamino)ethyl ester
CAS:302-40-9
MF:C20H25NO3
MW:327.42
EINECS:2061238
Product Categories:
Mol File:302-40-9.mol
Benactyzine Structure
Benactyzine Chemical Properties
Melting point 51°
Boiling point 465.31°C (rough estimate)
density 1.1392 (rough estimate)
refractive index 1.5614 (estimate)
storage temp. 2-8°C
pka11.31±0.29(Predicted)
NIST Chemistry ReferenceBenactyzine(302-40-9)
Safety Information
Hazard Codes T
Risk Statements 23/24/25
Safety Statements 36/37/39-45
Hazardous Substances Data302-40-9(Hazardous Substances Data)
Toxicityhuman,TDLo,intramuscular,100ug/kg (0.1mg/kg),SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE,"Possible Long-Term Health Effects of Short-Term Exposure to Chemical Agents," National Research Council, 3 vols., Washington, DC, National Academy Press, 1982-85Vol. 1, Pg. L1, 1982.
MSDS Information
ProviderLanguage
Benactyzine English
Benactyzine Usage And Synthesis
OriginatorSuavitil,Merck Sharp and Dohme,US,1957
DefinitionChEBI: 2-hydroxy-2,2-diphenylacetic acid 2-(diethylamino)ethyl ester is a diarylmethane.
Manufacturing Process114 parts of ethyl benzilate, 175 parts of β-diethylaminoethanol and 0.2 part of metallic sodium were placed in a flask attached to a total-reflux variable take-off fractionating column. The pressure was reduced to 100 mm and heat was applied by an oil bath the temperature of which was slowly raised to 90°C. During three hours of heating 17 parts of ethanol distilled (35.5°C). When the distillation of the ethanol became slow, the bath temperature was raised to 120°C. When the vapor temperature indicated distillation of the amino alcohol the take off valve was closed and the mixture was refluxed for one hour. At the end of this period the vapor temperature had dropped and two more parts of ethanol were distilled, The remaining aminoalcohol was slowly distilled for three hours. The pressure was then reduced to 20 mm and the remainder of the aminoalcohol distilled at 66°C. During the reaction the color of the solution changed from yellow to deep red. The residue was dissolved in 500 parts of ether, washed once with dilute brine, and three times with water, dried over sodium sulfate and finally dried over calcium sulfate. 500 parts of a saturated solution of HCl in absolute ether was added and the resulting precipitate filtered. Dry HCl gas was passed into the filtrate to a slight excess and the precipitate again filtered. The combined precipitates were washed with cold acetone. The 106 parts of product was purified by recrystallization from acetone as fine white crystals which melt at 177°- 178°C.
Therapeutic FunctionTranquilizer; Anticholinergic
Benactyzine Preparation Products And Raw materials
Raw materialsHydrochloric acid-->Sodium-->ETHYL BENZILATE
Preparation ProductsMethylbenactyzine bromide
Sodium acetate Methyl glycolate Piracetam 2-Hydroxyphenylacetic acid Cellulose acetate Glycine Levocetirizine 4-Hydroxyphenylacetic acid 4-Aminophenylacetic acid Butyl acetate ACETATE Vinyl acetate Levoceitrizine Hcl Iminodiacetic acid Ammonium acetate CHLOROPHOSPHONAZO III Nitrilotriacetic acid Glycolic acid

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